Search Results - "Proff, Julia"

Turning the tables on cytomegalovirus: targeting viral Fc receptors by CARs containing mutated CH2-CH3 IgG spacer domains by Proff, Julia, Brey, Charlotte U, Ensser, Armin, Holter, Wolfgang, Lehner, Manfred

“…During infection with human cytomegalovirus (HCMV) several viral proteins occur on cell surfaces in high quantity. We thus pursue an HLA-independent approach…”
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Redirecting T cells to Ewing's sarcoma family of tumors by a chimeric NKG2D receptor expressed by lentiviral transduction or mRNA transfection by Lehner, Manfred, Götz, Gabriel, Proff, Julia, Schaft, Niels, Dörrie, Jan, Full, Florian, Ensser, Armin, Muller, Yves A, Cerwenka, Adelheid, Abken, Hinrich, Parolini, Ornella, Ambros, Peter F, Kovar, Heinrich, Holter, Wolfgang

“…We explored the possibility to target Ewing's sarcoma family of tumors (ESFT) by redirecting T cells. To this aim, we considered NKG2D-ligands (NKG2D-Ls) as…”
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Serine-71 phosphorylation of Rac1 modulates downstream signaling by Schwarz, Janett, Proff, Julia, Hävemeier, Anika, Ladwein, Markus, Rottner, Klemens, Barlag, Britta, Pich, Andreas, Tatge, Helma, Just, Ingo, Gerhard, Ralf

“…The Rho GTPases Rac1 and Cdc42 regulate a variety of cellular functions by signaling to different signal pathways. It is believed that the presence of a…”
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Autocrine TNF is critical for the survival of human dendritic cells by regulating BAK, BCL-2, and FLIPL by Lehner, Manfred, Kellert, Beate, Proff, Julia, Schmid, Martina A, Diessenbacher, Philip, Ensser, Armin, Dörrie, Jan, Schaft, Niels, Leverkus, Martin, Kämpgen, Eckhart, Holter, Wolfgang

“…The life span of dendritic cells (DCs) is determined by the balance of pro- and antiapoptotic proteins. In this study, we report that serum-free cultured human…”
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Cytomegalovirus-Infected Cells Resist T Cell Mediated Killing in an HLA-Recognition Independent Manner by Proff, Julia, Walterskirchen, Christian, Brey, Charlotte, Geyeregger, Rene, Full, Florian, Ensser, Armin, Lehner, Manfred, Holter, Wolfgang

“…In order to explore the potential of HLA-independent T cell therapy for human cytomegalovirus (HCMV) infections, we developed a chimeric antigen receptor (CAR)…”
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A gB/CD3 bispecific BiTE antibody construct for targeting Human Cytomegalovirus-infected cells by Brey, Charlotte U., Proff, Julia, Teufert, Natascha, Salzer, Benjamin, Brozy, Johannes, Münz, Markus, Pendzialek, Jochen, Ensser, Armin, Holter, Wolfgang, Lehner, Manfred

“…Bispecific T cell engager (BiTE) antibody constructs are successfully used as cancer therapeutics. We hypothesized that this treatment strategy could also be…”
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