Search Results - "Proescholdt, Martin"

CD133+ and CD133- glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles by BEIER, Dagmar, HAU, Peter, PROESCHOLDT, Martin, LOHMEIER, Annette, WISCHHUSEN, Jörg, OEFNER, Peter J, AIGNER, Ludwig, BRAWANSKI, Alexander, BOGDAHN, Ulrich, BEIER, Christoph P

“…Although glioblastomas show the same histologic phenotype, biological hallmarks such as growth and differentiation properties vary considerably between…”
Get full text

Extent of Resection in Newly Diagnosed Glioblastoma: Impact of a Specialized Neuro-Oncology Care Center by Haj, Amer, Doenitz, Christian, Schebesch, Karl-Michael, Ehrensberger, Denise, Hau, Peter, Putnik, Kurt, Riemenschneider, Markus J, Wendl, Christina, Gerken, Michael, Pukrop, Tobias, Brawanski, Alexander, Proescholdt, Martin A

“…Treatment of glioblastoma (GBM) consists of microsurgical resection followed by concomitant radiochemotherapy and adjuvant chemotherapy. The best outcome…”
Get full text

Skull base meningiomas: neurological outcome after microsurgical resection by Scheitzach, Judith, Schebesch, Karl-Michael, Brawanski, Alexander, Proescholdt, Martin A.

“…Microsurgical resection is the primary treatment of skull base meningiomas. Maximal resection provides the best tumor control rates but can be associated with…”
Get full text

Intralesional TLR4 agonist treatment strengthens the organ defense against colonizing cancer cells in the brain by Blazquez, Raquel, Chuang, Han-Ning, Wenske, Britta, Trigueros, Laura, Wlochowitz, Darius, Liguori, Renato, Ferrazzi, Fulvia, Regen, Tommy, Proescholdt, Martin A., Rohde, Veit, Riemenschneider, Markus J., Stadelmann, Christine, Bleckmann, Annalen, Beißbarth, Tim, van Rossum, Denise, Hanisch, Uwe K., Pukrop, Tobias

“…Brain metastasis in breast cancer remains difficult to treat and its incidence is increasing. Therefore, the development of new therapies is of utmost clinical…”
Get full text

Characteristics and Outcome of Surgically Treated Patients with Intradural Extra- and Intramedullary Spinal Metastasis-A Single-Center Retrospective Case Series and Review by Salvotti, Hanna Veronika, Lein, Alexander, Proescholdt, Martin, Schmidt, Nils-Ole, Siller, Sebastian

“…Intradural spinal metastases are considered rare. At present, limited information is available on incidence, surgical management, and outcomes. We conducted a…”
Get full text

LEF1 supports metastatic brain colonization by regulating glutathione metabolism and increasing ROS resistance in breast cancer by Blazquez, Raquel, Rietkötter, Eva, Wenske, Britta, Wlochowitz, Darius, Sparrer, Daniela, Vollmer, Elena, Müller, Gunnar, Seegerer, Julia, Sun, Xueni, Dettmer, Katja, Barrantes‐Freer, Alonso, Stange, Lena, Utpatel, Kirsten, Bleckmann, Annalen, Treiber, Hannes, Bohnenberger, Hanibal, Lenz, Christof, Schulz, Matthias, Reimelt, Christian, Hackl, Christina, Grade, Marian, Büyüktas, Deram, Siam, Laila, Balkenhol, Marko, Stadelmann, Christine, Kube, Dieter, Krahn, Michael P., Proescholdt, Martin A., Riemenschneider, Markus J., Evert, Matthias, Oefner, Peter J., Klein, Chistoph A., Hanisch, Uwe K., Binder, Claudia, Pukrop, Tobias

“…More than half of all brain metastases show infiltrating rather than displacing growth at the macro‐metastasis/organ parenchyma interface (MMPI), a finding…”
Get full text

The Management of Brain Metastases-Systematic Review of Neurosurgical Aspects by Proescholdt, Martin A, Schödel, Petra, Doenitz, Christian, Pukrop, Tobias, Höhne, Julius, Schmidt, Nils Ole, Schebesch, Karl-Michael

“…The multidisciplinary management of patients with brain metastases (BM) consists of surgical resection, different radiation treatment modalities, cytotoxic…”
Get full text

PI3K: A master regulator of brain metastasis‐promoting macrophages/microglia by Blazquez, Raquel, Wlochowitz, Darius, Wolff, Alexander, Seitz, Stefanie, Wachter, Astrid, Perera‐Bel, Julia, Bleckmann, Annalen, Beißbarth, Tim, Salinas, Gabriela, Riemenschneider, Markus J., Proescholdt, Martin, Evert, Matthias, Utpatel, Kirsten, Siam, Laila, Schatlo, Bawarjan, Balkenhol, Marko, Stadelmann, Christine, Schildhaus, Hans‐Ulrich, Korf, Ulrike, Reinz, Eileen, Wiemann, Stefan, Vollmer, Elena, Schulz, Mathias, Ritter, Uwe, Hanisch, Uwe K., Pukrop, Tobias

“…Mutations and activation of the PI3K signaling pathway in breast cancer cells have been linked to brain metastases. However, here we describe that in some…”
Get full text

CXCR2-Blocking Has Context-Sensitive Effects on Rat Glioblastoma Cell Line Outgrowth (S635) in an Organotypic Rat Brain Slice Culture Depending on Microglia-Depletion (PLX5622) and Dexamethasone Treatment by Falter, Johannes, Lohmeier, Annette, Eberl, Petra, Stoerr, Eva-Maria, Koskimäki, Janne, Falter, Lena, Rossmann, Jakob, Mederer, Tobias, Schmidt, Nils Ole, Proescholdt, Martin

“…In glioblastoma (GBM), the interplay of different immune cell subtypes, cytokines, and/or drugs shows high context-dependencies. Interrelations between the…”
Get full text

Lactate-modulated induction of THBS-1 activates transforming growth factor (TGF)-beta2 and migration of glioma cells in vitro by Seliger, Corinna, Leukel, Petra, Moeckel, Sylvia, Jachnik, Birgit, Lottaz, Claudio, Kreutz, Marina, Brawanski, Alexander, Proescholdt, Martin, Bogdahn, Ulrich, Bosserhoff, Anja-Katrin, Vollmann-Zwerenz, Arabel, Hau, Peter

“…An important phenomenon observed in glioma metabolism is increased aerobic glycolysis in tumor cells, which is generally referred to as the Warburg effect…”
Get full text

Surgical resection of brain metastases-impact on neurological outcome by Schödel, Petra, Schebesch, Karl-Michael, Brawanski, Alexander, Proescholdt, Martin Andreas

“…Brain metastases (BM) develop in about 30% of all cancer patients. Surgery plays an important role in confirming neuropathological diagnosis, relieving mass…”
Get full text

Use of statins or NSAIDs and survival of patients with high-grade glioma by Seliger, Corinna, Schaertl, Julia, Gerken, Michael, Luber, Christian, Proescholdt, Martin, Riemenschneider, Markus J, Leitzmann, Michael F, Hau, Peter, Klinkhammer-Schalke, Monika

“…High-grade glioma (HGG) is associated with a limited prognosis. Drug repurposing has become of increasing interest to improve standard therapy. Statins and…”
Get full text

Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation by Leidgens, Verena, Proske, Judith, Rauer, Lisa, Moeckel, Sylvia, Renner, Kathrin, Bogdahn, Ulrich, Riemenschneider, Markus J, Proescholdt, Martin, Vollmann-Zwerenz, Arabel, Hau, Peter, Seliger, Corinna

“…Glioblastoma (GBM) is the most common and malignant type of primary brain tumor and associated with a devastating prognosis. Signal transducer and activator of…”
Get full text

Temozolomide preferentially depletes cancer stem cells in glioblastoma by Beier, Dagmar, Röhrl, Stefanie, Pillai, Deepu R, Schwarz, Stefanie, Kunz-Schughart, Leoni A, Leukel, Petra, Proescholdt, Martin, Brawanski, Alexander, Bogdahn, Ulrich, Trampe-Kieslich, Ariane, Giebel, Bernd, Wischhusen, Jörg, Reifenberger, Guido, Hau, Peter, Beier, Christoph P

“…The prognosis of patients suffering from glioblastoma (GBM) is dismal despite multimodal therapy. Although chemotherapy with temozolomide may contain tumor…”
Get full text

Function of carbonic anhydrase IX in glioblastoma multiforme by Proescholdt, Martin A, Merrill, Marsha J, Stoerr, Eva-Maria, Lohmeier, Annette, Pohl, Fabian, Brawanski, Alexander

“…Carbonic anhydrase (CA) IX is over-expressed in glioblastoma; however, its functions in this context are unknown. Metabolically, glioblastomas are highly…”
Get full text

Systematic investigation of CMTM family genes suggests relevance to glioblastoma pathogenesis and CMTM1 and CMTM3 as priority targets by Delic, Sabit, Thuy, Andreas, Schulze, Markus, Proescholdt, Martin A., Dietrich, Peter, Bosserhoff, Anja-Katrin, Riemenschneider, Markus J.

“…The novel CKLF‐like Marvel Transmembrane Domain‐containing gene family (CMTM) consists of 8 members (CMTM1–8). As little is known about the oncogenic impact of…”
Get full text

Extracellular vesicles secreted by 3D tumor organoids are enriched for immune regulatory signaling biomolecules compared to conventional 2D glioblastoma cell systems by Schuster, Martina, Braun, Frank K, Chiang, Dapi Meng-Lin, Ludwig, Christina, Meng, Chen, Grätz, Christian, Kirchner, Benedikt, Proescholdt, Martin, Hau, Peter, Steinlein, Ortrud K, Pfaffl, Michael W, Riemenschneider, Markus J, Reithmair, Marlene

“…Newer 3D culturing approaches are a promising way to better mimic the tumor microenvironment and to study the interactions between the heterogeneous cell…”
Get full text

Metabolic Heterogeneity of Brain Tumor Cells of Proneural and Mesenchymal Origin by Seliger, Corinna, Meyer, Anne-Louise, Leidgens, Verena, Rauer, Lisa, Moeckel, Sylvia, Jachnik, Birgit, Proske, Judith, Dettmer, Katja, Rothhammer-Hampl, Tanja, Kaulen, Leon D., Riemenschneider, Markus J., Oefner, Peter J., Kreutz, Marina, Schmidt, Nils-Ole, Merrill, Marsha, Uhl, Martin, Renner, Kathrin, Vollmann-Zwerenz, Arabel, Proescholdt, Martin, Hau, Peter

“…Brain-tumor-initiating cells (BTICs) of proneural and mesenchymal origin contribute to the highly malignant phenotype of glioblastoma (GB) and resistance to…”
Get full text

Surgical resection of symptomatic brain metastases improves the clinical status and facilitates further treatment by Schödel, Petra, Jünger, Stephanie T., Wittersheim, Maike, Reinhardt, Hans Christian, Schmidt, Nils‐Ole, Goldbrunner, Roland, Proescholdt, Martin, Grau, Stefan

“…Background Brain metastases (BM) frequently cause focal neurological deficits leading to a reduced Karnofsky performance score (KPS). Since KPS is routinely…”
Get full text

Aberrant expression of c-Jun in glioblastoma by internal ribosome entry site (IRES)-mediated translational activation by Blau, Lior, Knirsh, Revital, Ben-Dror, Iris, Oren, Sivan, Kuphal, Silke, Hau, Peter, Proescholdt, Martin, Bosserhoff, Anja-Katrin, Vardimon, Lily

“…Although the protooncogene c-Jun plays a critical role in cell proliferation, cell death, and malignant transformation, DNA microarray screens have identified…”
Get full text