Treatment with thyroid hormones and grape juice in a model of pulmonary hypertension: the response of apoptosis and inflammation

This study explored the association of cardioprotective role of thyroid hormones (TH) and benefit effects of grape juice (GJ) on vascular function against the apoptosis and inflammation associated with monocrotaline (MCT)-induced pulmonary hypertension (PH). Wistar rats were distributed into five gr...

Full description

Saved in:

Bibliographic Details
Published in:	Anais da Academia Brasileira de Ciências Vol. 96; no. 4; p. e20240338
Main Authors:	Proença, Isabel Cristina T, Türck, Patrick, Ortiz, Vanessa D, Proença, Cristina C, Belló-Klein, Adriane, Castro, Alexandre L DE, Dani, Caroline, Araujo, Alex Sander R
Format:	Journal Article
Language:	English
Published:	Brazil Academia Brasileira de Ciências 2024
Subjects:	Animals Apoptosis - drug effects BAX Bcl2 caspases 9 and 3 Disease Models, Animal Fruit and Vegetable Juices Hypertension, Pulmonary - drug therapy Inflammation - drug therapy Male Monocrotaline MULTIDISCIPLINARY SCIENCES NLRP3 Rats Rats, Wistar Thyroid Hormones Vitis - chemistry Bcl2 NLRP3 BAX caspases 9 and 3 monocrotaline
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	This study explored the association of cardioprotective role of thyroid hormones (TH) and benefit effects of grape juice (GJ) on vascular function against the apoptosis and inflammation associated with monocrotaline (MCT)-induced pulmonary hypertension (PH). Wistar rats were distributed into five groups: control; PH (MCT 60mg/kg i.p.); PH+GJ (GJ-7 µL/g / day, gavage for 14 days); PH+TH (T3, 2μg/100g/day, and T4, 8μg/100g/day, by gavage for 14 days); and PH+TH+GJ. Echocardiographic, morphometric measurements and expression of proteins associated with apoptosis and inflammation were evaluated. The reduced cardiac output (35%) in PH was attenuated in the PH+GJ, PH+TH, and PH+TH+GJ groups (P<0.05). Both GJ and TH had no effect on the PH-induced hypertrophy index. The PH + TH group showed reduced BAX (~90%) and increased Bcl2 levels (~80%) as compared to PH group (P<0.05). The PH-induced increase in caspase 3 was diminished (~92%) in the PH+TH (P<0.05). Both GJ and TH, isolated and combined, reduced caspase 9 levels (~70%). PH-provoked elevated NLRP3 levels was decreased (~90%) in PH+TH (P<0.05). The therapeutic approach showed cardioprotective effects in the PH model which may be mediated by mitigation of apoptosis and inflammation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0001-3765 1678-2690 1678-2690
DOI:	10.1590/0001-3765202420240338