Search Results - "Proctor, Richard A."

Persistence of Staphylococcus aureus: Multiple Metabolic Pathways Impact the Expression of Virulence Factors in Small-Colony Variants (SCVs) by Tuchscherr, Lorena, Löffler, Bettina, Proctor, Richard A.

“…Staphylococcus aureus is able to survive within host cells by switching its phenotype to the small-colony variant (SCV) phenotype. The emergence of SCVs is…”
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Development of a vaccine against Staphylococcus aureus invasive infections: Evidence based on human immunity, genetics and bacterial evasion mechanisms by Miller, Lloyd S, Fowler, Vance G, Shukla, Sanjay K, Rose, Warren E, Proctor, Richard A

“…ABSTRACT Invasive Staphylococcus aureus infections are a leading cause of morbidity and mortality in both hospital and community settings, especially with the…”
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At the Crossroads of Bacterial Metabolism and Virulence Factor Synthesis in Staphylococci by SOMERVILLE, Greg A, PROCTOR, Richard A

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The Complex Intracellular Lifecycle of Staphylococcus aureus Contributes to Reduced Antibiotic Efficacy and Persistent Bacteremia by Volk, Cecilia F, Proctor, Richard A, Rose, Warren E

“…bacteremia continues to be associated with significant morbidity and mortality, despite improvements in diagnostics and management. Persistent infections pose…”
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Staphylococcus aureus as an intracellular pathogen: the role of small colony variants by Sendi, Parham, Proctor, Richard A

“…Increasing evidence indicates that Staphylococcus aureus might be a facultative intracellular pathogen. In particular, certain subpopulations, called small…”
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Antibiotic activity against small-colony variants of Staphylococcus aureus: review of in vitro, animal and clinical data by Garcia, Laetitia G, Lemaire, Sandrine, Kahl, Barbara C, Becker, Karsten, Proctor, Richard A, Denis, Olivier, Tulkens, Paul M, Van Bambeke, Françoise

“…The pathogen Staphylococcus aureus uses various strategies for persisting in the host, among which switching to a small-colony variant (SCV) phenotype is of…”
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Staphylococcus aureus panton-valentine leukocidin is a very potent cytotoxic factor for human neutrophils by Löffler, Bettina, Hussain, Muzaffar, Grundmeier, Matthias, Brück, Michaela, Holzinger, Dirk, Varga, Georg, Roth, Johannes, Kahl, Barbara C, Proctor, Richard A, Peters, Georg

“…The role of the pore-forming Staphylococcus aureus toxin Panton-Valentine leukocidin (PVL) in severe necrotizing diseases is debated due to conflicting data…”
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Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection by Tuchscherr, Lorena, Medina, Eva, Hussain, Muzaffar, Völker, Wolfgang, Heitmann, Vanessa, Niemann, Silke, Holzinger, Dirk, Roth, Johannes, Proctor, Richard A., Becker, Karsten, Peters, Georg, Löffler, Bettina

“…Staphylococcus aureus is a frequent cause for serious, chronic and therapy‐refractive infections in spite of susceptibility to antibiotics in vitro . In…”
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Carotenoid-Related Alteration of Cell Membrane Fluidity Impacts Staphylococcus aureus Susceptibility to Host Defense Peptides by MISHRA, Nagendra N, LIU, George Y, YEAMAN, Michael R, NAST, Cynthia C, PROCTOR, Richard A, MCKINNELL, James, BAYER, Arnold S

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New Mechanistic Insights into Purine Biosynthesis with Second Messenger c-di-AMP in Relation to Biofilm-Related Persistent Methicillin-Resistant Staphylococcus aureus Infections by Li, Liang, Li, Yi, Zhu, Fengli, Cheung, Ambrose L, Wang, Genzhu, Bai, Guangchun, Proctor, Richard A, Yeaman, Michael R, Bayer, Arnold S, Xiong, Yan Q

“…Persistent methicillin-resistant Staphylococcus aureus (MRSA) endovascular infections represent a significant clinically challenging subset of invasive,…”
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Thymidine-Dependent Staphylococcus aureus Small-Colony Variants Are Induced by Trimethoprim-Sulfamethoxazole (SXT) and Have Increased Fitness during SXT Challenge by Kriegeskorte, Andre, Lorè, Nicola Ivan, Bragonzi, Alessandra, Riva, Camilla, Kelkenberg, Marco, Becker, Karsten, Proctor, Richard A, Peters, Georg, Kahl, Barbara C

“…Trimethoprim-sulfamethoxazole (SXT) is a possible alternative for the treatment of community- and hospital-acquired methicillin-resistant Staphylococcus aureus…”
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Failures in Clinical Treatment of Staphylococcus aureus Infection with Daptomycin Are Associated with Alterations in Surface Charge, Membrane Phospholipid Asymmetry, and Drug Binding by JONES, Tiffanny, YEAMAN, Michael R, SAKOULAS, George, YANG, Soo-Jin, PROCTOR, Richard A, SAHL, Hans-Georg, SCHRENZEL, Jacques, XIONG, Yan Q, BAYER, Arnold S

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Staphylococcus aureus adaptive evolution: Recent insights on how immune evasion, immunometabolic subversion and host genetics impact vaccine development by Wong Fok Lung, Tania, Chan, Liana C, Prince, Alice, Yeaman, Michael R, Archer, Nathan K, Aman, M Javad, Proctor, Richard A

“…Despite meritorious attempts, a vaccine that prevents infection or mitigates severity has not yet achieved efficacy endpoints in prospective, randomized…”
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Cultivation conditions and the diffusion of oxygen into culture media: the rationale for the flask-to-medium ratio in microbiology by Somerville, Greg A, Proctor, Richard A

“…Bacterial cultivation requires consideration of three things: The bacterial strain, cultivation medium, and cultivation conditions. Most microbiologists…”
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Klebsiella pneumoniae exhibiting a phenotypic hyper-splitting phenomenon including the formation of small colony variants by Doğan, Eyüp, Sydow, Katharina, Heiden, Stefan E, Eger, Elias, Wassilew, Georgi, Proctor, Richard A, Bohnert, Jürgen A, Idelevich, Evgeny A, Schaufler, Katharina, Becker, Karsten

“…In this study, we characterized a strain in a patient with shrapnel hip injury, which resulted in multiple phenotypic changes, including the formation of a…”
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Daptomycin resistance mechanisms in clinically derived Staphylococcus aureus strains assessed by a combined transcriptomics and proteomics approach by Fischer, Adrien, Yang, Soo-Jin, Bayer, Arnold S., Vaezzadeh, Ali R., Herzig, Sébastien, Stenz, Ludwig, Girard, Myriam, Sakoulas, George, Scherl, Alexander, Yeaman, Michael R., Proctor, Richard A., Schrenzel, Jacques, François, Patrice

“…Objectives The development of daptomycin resistance in Staphylococcus aureus is associated with clinical treatment failures. The mechanism(s) of such…”
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Heterogeneity of genetic pathways toward daptomycin nonsusceptibility in Staphylococcus aureus determined by adjunctive antibiotics by Berti, Andrew D, Baines, Sarah L, Howden, Benjamin P, Sakoulas, George, Nizet, Victor, Proctor, Richard A, Rose, Warren E

“…Daptomycin is increasingly used in combination with other antibiotics to enhance antimicrobial efficacy and/or to mitigate the emergence of daptomycin…”
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Development of a Staphylococcus aureus Vaccine: An Ongoing Journey by Proctor, Richard A

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Identification of differentially expressed small non-protein-coding RNAs in Staphylococcus aureus displaying both the normal and the small-colony variant phenotype by Abu-Qatouseh, Luay F., Chinni, Suresh V., Seggewiß, Jochen, Proctor, Richard A., Brosius, Jürgen, Rozhdestvensky, Timofey S., Peters, Georg, von Eiff, Christof, Becker, Karsten

“…The emerging interest in RNA research is due to the discovery that bacterial non-protein-coding RNAs (npcRNAs; often referred to as “non-coding RNAs”) are…”
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Evidence of Neutralizing and Non-Neutralizing Anti-Glucosaminidase Antibodies in Patients With S. Aureus Osteomyelitis and Their Association With Clinical Outcome Following Surgery in a Clinical Pilot by Sherchand, Shardulendra Prasad, Adhikari, Rajan P, Muthukrishnan, Gowrishankar, Kanipakala, Tulasikumari, Owen, John R, Xie, Chao, Aman, M Javad, Proctor, Richard A, Schwarz, Edward M, Kates, Stephen L

“…osteomyelitis remains a very challenging condition; recent clinical studies have shown infection control rates following surgery/antibiotics to be ~60%…”
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