Search Results - "Proctor, Martina"

Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins by Das, Indrajit, Png, Chin Wen, Oancea, Iulia, Hasnain, Sumaira Z, Lourie, Rohan, Proctor, Martina, Eri, Rajaraman D, Sheng, Yong, Crane, Denis I, Florin, Timothy H, McGuckin, Michael A

“…Endoplasmic reticulum (ER) stress in intestinal secretory cells has been linked with colitis in mice and inflammatory bowel disease (IBD). Endogenous…”
Get full text

The ATM Ser49Cys Variant Effects ATM Function as a Regulator of Oncogene-Induced Senescence by Atkinson, Caroline, McInerney-Leo, Aideen M, Proctor, Martina, Lanagan, Catherine, Stevenson, Alexander J, Dehkhoda, Farhad, Caole, Mary, Maas, Ellie, Ainger, Stephen, Pritchard, Antonia L, Johansson, Peter A, Leo, Paul, Hayward, Nicholas K, Sturm, Richard A, Duncan, Emma L, Gabrielli, Brian

“…An apical component of the cell cycle checkpoint and DNA damage repair response is the ataxia-telangiectasia mutated (ATM) Ser/Thr protein kinase. A variant of…”
Get full text

Mechanism of action of the third generation benzopyrans and evaluation of their broad anti-cancer activity in vitro and in vivo by Stevenson, Alexander J., Ager, Eleanor I., Proctor, Martina A., Škalamera, Dubravka, Heaton, Andrew, Brown, David, Gabrielli, Brian G.

“…Successive rounds of chemical modification in three generations of benzopyran molecules have shown to select for different mechanisms of actions and…”
Get full text

Endogenous Replication Stress Marks Melanomas Sensitive to CHEK1 Inhibitors In Vivo by Oo, Zay Yar, Stevenson, Alexander J, Proctor, Martina, Daignault, Sheena M, Walpole, Sebastian, Lanagan, Catherine, Chen, James, Škalamera, Dubravka, Spoerri, Loredana, Ainger, Stephen A, Sturm, Richard A, Haass, Nikolas K, Gabrielli, Brian

“…Checkpoint kinase 1 inhibitors (CHEK1i) have single-agent activity and Here, we have investigated the molecular basis of this activity. We have assessed a…”
Get full text

Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine by Oo, Zay Yar, Proctor, Martina, Stevenson, Alexander J., Nazareth, Deborah, Fernando, Madushan, Daignault, Sheena M., Lanagan, Catherine, Walpole, Sebastian, Bonazzi, Vanessa, Škalamera, Dubravka, Snell, Cameron, Haass, Nikolas K., Larsen, Jill E., Gabrielli, Brian

“…Drugs such as gemcitabine that increase replication stress are effective chemotherapeutics in a range of cancer settings. These drugs effectively block…”
Get full text

Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumours by Fernando, Madushan, Duijf, Pascal H. G., Proctor, Martina, Stevenson, Alexander J., Ehmann, Anna, Vora, Shivam, Skalamera, Dubravka, Adams, Mark, Gabrielli, Brian

“…Defective DNA repair is being demonstrated to be a useful target in cancer treatment. Currently, defective repair is identified by specific gene mutations,…”
Get full text

358 Alleviation of Acute Drug-Induced Liver Injury Following Acetaminophen Overdose by Therapeutic Blockade of E-Selectin in Preclinical Mouse Model by Oancea, Iulia, Barbier, Valerie, Chee, David, Lourie, Rohan, Movva, Ramya, Proctor, Martina A, Begun, Jakob, Magnani, John L, Florin, Timothy H, Winkler, Ingrid

Get full text

Concept maps which visualise the artifice of teaching sequence: Cognition, linguistic and problem-based views on a common teaching problem by Hay, David B, Proctor, Martina

“…This paper is concerned with the ways in which undergraduates are first introduced to Law of Contract in a University Law School. Concept mapping is used to…”
Get full text

Abstract 1443: CHKing melanoma: CHK1 inhibitor +low dose hydroxyurea triggers immunogenic cell death and immunostimulatory cytokine expression to drive an anti-tumor immune response by Gabrielli, Brian G., Proctor, Martina, Cruz, Jazmina Gonzalez, Zeng, Bijun, Dolcetti, Riccardo, Keane, Colm, Haass, Nikolas, Wells, James

“…Abstract About half of melanomas respond to immunotherapy, but we currently lack reliable markers to identify likely responders. Therefore, a large number of…”
Get full text

Inhibition of Aurora A and Aurora B Is Required for the Sensitivity of HPV-Driven Cervical Cancers to Aurora Kinase Inhibitors by Martin, David, Fallaha, Sora, Proctor, Martina, Stevenson, Alexander, Perrin, Lewis, McMillan, Nigel, Gabrielli, Brian

“…The activity and efficacy of Aurora inhibitors have been reported in a wide range of cancer types. The most prominent Aurora inhibitor is alisertib, an…”
Get full text

Checkpoint kinase 1 inhibitor + low‐dose hydroxyurea efficiently kills BRAF inhibitor‐ and immune checkpoint inhibitor‐resistant melanomas by Zeng, Zhen, Ngo, Hung Long, Proctor, Martina, Rizos, Helen, Dolcetti, Riccardo, Cruz, Jazmina Gonzalez, Wells, James W., Gabrielli, Brian

“…Treatment of melanomas with targeted and immunotherapies has proven effective, but resistance to both treatments is a common outcome leaving a high proportion…”
Get full text

Abstract 1236: Subclinical doses and choice of replication stress inducer in combination with CHK1 inhibitors for optimal tumor control and immune responses in vitro and in vivo by Oo, Zay Yar, Proctor, Martina, Stevenson, Alex, Nazareth, Deborah, Larsen, Jill, Haass, Nikolas, Gabrielli, Brian G.

“…Abstract Background: Lung cancer and melanoma are responsible for almost 25% of cancer deaths in Australia. Despite recent progress with targeted and…”
Get full text

Abstract A069: Increasing replication stress by reducing nucleoside levels sensitizes melanomas and non-small cell lung cancers to CHK1 inhibitor in vitro and in vivo by Oo, Zay Yar, Proctor, Martina, Stevenson, Alexander, Larsen, Jill, Gabrielli, Brian G.

“…Abstract CHK1 inhibitors are being investigated as chemosensitizing agents with agents that increase replication stress. Here we have investigated the…”
Get full text

Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression by Proctor, Martina, Gonzalez Cruz, Jazmina L, Daignault-Mill, Sheena M, Veitch, Margaret, Zeng, Bijun, Ehmann, Anna, Sabdia, Muhammed, Snell, Cameron, Keane, Colm, Dolcetti, Riccardo, Haass, Nikolas K, Wells, James W, Gabrielli, Brian

“…Drugs selectively targeting replication stress have demonstrated significant preclinical activity, but this has not yet translated into an effective clinical…”
Get full text

Neutralizing IL-23 is superior to blocking IL-17 in suppressing intestinal inflammation in a spontaneous murine colitis model by Wang, Ran, Hasnain, Sumaira Z, Tong, Hui, Das, Indrajit, Che-Hao Chen, Alice, Oancea, Iulia, Proctor, Martina, Florin, Timothy H, Eri, Rajaraman D, McGuckin, Michael A

“…IL-23/T(H)17 inflammatory responses are regarded as central to the pathogenesis of inflammatory bowel disease, but clinically IL-17A antibodies have shown low…”
Get full text

Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins by Das, Indrajit, Png, Chin Wen, Oancea, Iulia, Hasnain, Sumaira Z., Lourie, Rohan, Proctor, Martina, Eri, Rajaraman D., Sheng, Yong, Crane, Denis I., Florin, Timothy H., McGuckin, Michael A.

Get full text