Search Results - "Procopio, Francesco A"

Inducible HIV-1 Reservoir Quantification: Clinical Relevance, Applications and Advancements of TILDA by Lungu, Cynthia, Banga, Riddhima, Gruters, Rob A, Procopio, Francesco A

“…The presence of a stable HIV-1 reservoir persisting over time despite effective antiretroviral suppression therapy precludes a cure for HIV-1. Characterizing…”
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The deficiency in Th2-like Tfh cells affects the maturation and quality of HIV-specific B cell response in viremic infection by Noto, Alessandra, Suffiotti, Madeleine, Joo, Victor, Mancarella, Antonio, Procopio, Francesco A., Cavet, Guy, Leung, Yvonne, Corpataux, Jean-Marc, Cavassini, Matthias, Riva, Agostino, Stamatatos, Leonidas, Gottardo, Raphael, McDermott, Adrian B., Koup, Richard A., Fenwick, Craig, Perreau, Matthieu, Pantaleo, Giuseppe

“…Optimal T follicular helper (Tfh) cells function is important to promote the development of germinal centers and maturation of high affinity antigen-specific B…”
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Blood CXCR3 + CD4 T Cells Are Enriched in Inducible Replication Competent HIV in Aviremic Antiretroviral Therapy-Treated Individuals by Banga, Riddhima, Procopio, Francesco A, Ruggiero, Alessandra, Noto, Alessandra, Ohmiti, Khalid, Cavassini, Matthias, Corpataux, Jean-Marc, Paxton, William A, Pollakis, Georgios, Perreau, Matthieu

“…We recently demonstrated that lymph nodes (LNs) PD-1 /T follicular helper (Tfh) cells from antiretroviral therapy (ART)-treated HIV-infected individuals were…”
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Human macrophages and monocyte-derived dendritic cells stimulate the proliferation of endothelial cells through midkine production by Said, Elias A, Al-Dughaishi, Sumaya, Al-Hatmi, Wadha, Al-Reesi, Iman, Al-Riyami, Marwa, Al-Balushi, Mohammed S, Al-Bimani, Atika, Al-Busaidi, Juma Z, Al-Khabori, Murtadha, Al-Kindi, Salam, Procopio, Francesco A, Al-Rashdi, Afrah, Al-Ansari, Aliyaa, Babiker, Hamza, Koh, Crystal Y, Al-Naamani, Khalid, Pantaleo, Giuseppe, Al-Jabri, Ali A

“…The cytokine midkine (MK) is a growth factor that is involved in different physiological processes including tissue repair, inflammation, the development of…”
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Differential Production of Midkine and Pleiotrophin by Innate APCs upon Stimulation through Nucleic Acid-Sensing TLRs by Said, Elias A., Al-Dughaishi, Sumaya, Al-Hatmi, Wadha, Al-Reesi, Iman, Al-Balushi, Mohammed S., Al-Bimani, Atika, Al-Busaidi, Juma Z., Al-Riyami, Marwa, Al-Khabori, Murtadha, Al-Kindi, Salam, Procopio, Francesco A., Al-Sinawi, Shadia, Al-Ansari, Aliyaa, Koh, Crystal Y., Al-Naamani, Khalid, Al-Jabri, Ali A.

“…Midkine (MK) and pleiotrophin (PTN) belong to the same family of cytokines. They have similar sequences and functions. Both have important roles in cellular…”
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Myeloid dendritic cells induce HIV-1 latency in non-proliferating CD4+ T cells by Evans, Vanessa A, Kumar, Nitasha, Filali, Ali, Procopio, Francesco A, Yegorov, Oleg, Goulet, Jean-Philippe, Saleh, Suha, Haddad, Elias K, da Fonseca Pereira, Candida, Ellenberg, Paula C, Sekaly, Rafick-Pierre, Cameron, Paul U, Lewin, Sharon R

“…Latently infected resting CD4(+) T cells are a major barrier to HIV cure. Understanding how latency is established, maintained and reversed is critical to…”
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Inter-Laboratory Reproducibility of Inducible HIV-1 Reservoir Quantification by TILDA by Lungu, Cynthia, Procopio, Francesco A, Overmars, Ronald J, Beerkens, Rob J J, Voermans, Jolanda J C, Rao, Shringar, Prins, Henrieke A B, Rokx, Casper, Pantaleo, Giuseppe, Vijver, David A M C van de, Mahmoudi, Tokameh, Boucher, Charles A B, Gruters, Rob A, Kampen, Jeroen J A van

“…Substantial efforts to eliminate or reduce latent HIV-1 reservoirs are underway in clinical trials and have created a critical demand for sensitive, accurate,…”
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CIITA-Induced MHC Class II Expression in Mammary Adenocarcinoma Leads to a Th1 Polarization of the Tumor Microenvironment, Tumor Rejection, and Specific Antitumor Memory by MORTARA, Lorenzo, CASTELLANI, Patrizia, MEAZZA, Raffaella, TOSI, Giovanna, DE LERMA BARBARO, Andrea, PROCOPIO, Francesco A, COMES, Alberto, ZARDI, Luciano, FERRINI, Silvano, ACCOLLA, Roberto S

“…Purpose: We have shown previously that the MHC class II–negative murine TS/A adenocarcinoma is rejected in vivo if induced to express MHC class II molecules by…”
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TILDA: Tat/Rev Induced Limiting Dilution Assay by Lungu, Cynthia, Procopio, Francesco A

“…Recently the Tat/rev Induced Limiting Dilution Assay, or TILDA, has been proposed as a possible alternative method to quantify the HIV-1 reservoir. TILDA…”
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HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation by Sékaly, Rafick-Pierre, Chomont, Nicolas, El-Far, Mohamed, Ancuta, Petronela, Trautmann, Lydie, Procopio, Francesco A, Yassine-Diab, Bader, Boucher, Geneviève, Boulassel, Mohamed-Rachid, Ghattas, Georges, Brenchley, Jason M, Schacker, Timothy W, Hill, Brenna J, Douek, Daniel C, Routy, Jean-Pierre, Haddad, Elias K

“…Highly active antiretroviral therapy is unable to eliminate HIV infection, because the virus persists in latently infected CD4 + T cells—a so-called virus…”
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CD32 + and PD-1 + Lymph Node CD4 T Cells Support Persistent HIV-1 Transcription in Treated Aviremic Individuals by Noto, Alessandra, Procopio, Francesco A, Banga, Riddhima, Suffiotti, Madeleine, Corpataux, Jean-Marc, Cavassini, Matthias, Riva, Agostino, Fenwick, Craig, Gottardo, Raphael, Perreau, Matthieu, Pantaleo, Giuseppe

“…A recent study conducted in blood has proposed CD32 as the marker identifying the "elusive" HIV reservoir. We have investigated the distribution of CD32 CD4 T…”
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Detection of antisense protein (ASP) RNA transcripts in individuals infected with human immunodeficiency virus type 1 (HIV-1) by Mancarella, Antonio, Procopio, Francesco A, Achsel, Tilmann, De Crignis, Elisa, Foley, Brian T, Corradin, Giampietro, Bagni, Claudia, Pantaleo, Giuseppe, Graziosi, Cecilia

“…The detection of antisense RNA is hampered by reverse transcription (RT) non-specific priming, due to the ability of RNA secondary structures to prime RT in…”
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Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells by Youngblood, Ben, Noto, Alessandra, Porichis, Filippos, Akondy, Rama S, Ndhlovu, Zaza M, Austin, James W, Bordi, Rebeka, Procopio, Francesco A, Miura, Toshiyuki, Allen, Todd M, Sidney, John, Sette, Alessandro, Walker, Bruce D, Ahmed, Rafi, Boss, Jeremy M, Sékaly, Rafick-Pierre, Kaufmann, Daniel E

“…Ag-specific CD8 T cells play a critical role in controlling HIV infection but eventually lose antiviral functions in part because of expression and signaling…”
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Comparative analysis and generation of a robust HIV-1 DNA quantification assay by Thomas, Jordan, Ruggiero, Alessandra, Procopio, Francesco A., Pantaleo, Giuseppe, Paxton, William A., Pollakis, Georgios

“…•Non-replicative J-Lat clones are the most suitable cell types for HIV-1 DNA quantification standards.•Correlation between assays when quantifying low copy…”
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Current approaches to assess HIV-1 persistence by Banga, Riddhima, Procopio, Francesco A, Perreau, Matthieu

“…PURPOSE OF REVIEWThe persistence of HIV within long-lived HIV-infected CD4 T cells is the primary obstacle towards HIV eradication and numerous strategies are…”
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Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis by van Grevenynghe, Julien, Cubas, Rafael A, Noto, Alessandra, DaFonseca, Sandrina, He, Zhong, Peretz, Yoav, Filali-Mouhim, Abdelali, Dupuy, Franck P, Procopio, Francesco A, Chomont, Nicolas, Balderas, Robert S, Said, Elias A, Boulassel, Mohamed-Rachid, Tremblay, Cecile L, Routy, Jean-Pierre, Sékaly, Rafick-Pierre, Haddad, Elias K

“…Loss of memory B cells occurs from the onset of HIV-1 infection and persists into the chronic stages of infection. Lack of survival of these cells, even in…”
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Transcription factor FOXO3a controls the persistence of memory CD4 + T cells during HIV infection by Sekaly, Rafick-Pierre, Boucher, Genevieve, Wilkinson, Peter, Procopio, Francesco A, Gimmig, Sylvain, Chomont, Nicolas, Shi, Yu, Riou, Catherine, Zhang, Yuwei, Balderas, Robert S, Boulassel, Mohamed-Rachid, Routy, Jean-Pierre, Far, Mohamed El, Said, Elias A, He, Zhong, van Grevenynghe, Julien, Yassine-Diab, Bader, Haddad, Elias K, Trautmann, Lydie

“…The persistence of central memory CD4 + T cells (T CM cells) is a major correlate of immunological protection in HIV/AIDS, as the rate of T CM cell decline…”
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The MHC class II transactivator (CIITA) mRNA stability is critical for the HLA class II gene expression in myelomonocytic cells by De Lerma Barbaro, Andrea, Procopio, Francesco A., Mortara, Lorenzo, Tosi, Giovanna, Accolla, Roberto S.

“…The human promyelocytic U937 cells express detectable levels of MHC class II (MHC‐II) molecules. Treatment with 12‐o‐‐tetradecanoyl phorbol 13‐acetate (TPA),…”
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Unique features of memory T cells in HIV elite controllers: a systems biology perspective by Fonseca, Simone G, Procopio, Francesco A, Goulet, Jean-Philippe, Yassine-Diab, Bader, Ancuta, Petronela, Sékaly, Rafick-Pierre

“…PURPOSE OF REVIEWElite controllers constitute a rare group of HIV-infected individuals who control HIV replication and maintain normal CD4 cell counts without…”
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Lymph node architecture collapse and consequent modulation of FOXO3a pathway on memory T- and B-cells during HIV infection by van Grevenynghe, Julien, Halwani, Rabih, Chomont, Nicolas, Ancuta, Petronela, Peretz, Yoav, Tanel, Andre, Procopio, Francesco A, shi, Yu, Said, Elias A, Haddad, Elias K, Sekaly, Rafick P

“…Abstract Lymph nodes (LNs) represent the principal site where antigen-specific memory T- and B-cell responses are primed and differentiated into memory and…”
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