Oligoribonucleotide-Containing Nanocomplexes Based on Aminopropylsilanol Nanoparticles as Effective Inhibitors of Influenza A Virus Replication

Oligoribonucleotide-Containing Nanocomplexes Based on Aminopropylsilanol Nanoparticles as Effective Inhibitors of Influenza A Virus Replication

Titanium dioxide or aminopropylsilanol nanoparticles were shown to be effective vehicles for delivering oligodeoxyribonucleotides and deoxyribozymes to cells to affect target nucleic acids. In this paper, the proposed principle of the delivery has been implemented in relation to oligoribonucleotides...

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Bibliographic Details
Published in:Moscow University biological sciences bulletin Vol. 78; no. 4; pp. 249 - 254
Main Authors: Repkova, M. N., Mazurkov, O. Yu, Filippova, E. I., Procenko, M. A., Mazurkova, N. A., Chelobanov, B. P., Levina, A. S., Zarytova, V. F.
Format: Journal Article
Language:English
Published: Moscow Pleiades Publishing 01-12-2023
Springer Nature B.V
Subjects:
Biochemistry
Biomedical and Life Sciences
Cell Biology
Deoxyribozymes
Influenza A
Life Sciences
Nanoparticles
Plant Sciences
Replication
Research Article
siRNA
Titanium dioxide
Viruses
Zoology
nanocomplexes
cell delivery
antiviral activity
aminopropylsilanol nanoparticles
oligoribonucleotides
influenza A virus
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Summary:Titanium dioxide or aminopropylsilanol nanoparticles were shown to be effective vehicles for delivering oligodeoxyribonucleotides and deoxyribozymes to cells to affect target nucleic acids. In this paper, the proposed principle of the delivery has been implemented in relation to oligoribonucleotides (ORN), components of short interfering RNAs (siRNAs). It has been shown that the obtained ORN-containing nanocomplexes (Si~NH 2 ·ORN) based on aminopropylsilanol nanoparticles penetrate eukaryotic cells. These nanocomplexes have been investigated as agents for suppressing the replication of influenza A virus (IAV) in the cellular system. It has been shown that the ORN strands targeted to (+)RNA and (–)RNA of the IAV 5th segment reduces the titer of the virus by 99.7% and 98.4%, respectively. Thus, oligoribonucleotides in the Si~NH 2 ·ORN nanocomplexes effectively inhibit the replication of the influenza A virus.
ISSN:0096-3925
1934-791X
DOI:10.3103/S0096392524600431