Search Results - "Proceedings of the Japan Academy. Series B. Physical and biological sciences"

Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase by FURUTA, Yousuke, KOMENO, Takashi, NAKAMURA, Takaaki

“…Favipiravir (T-705; 6-fluoro-3-hydroxy-2-pyrazinecarboxamide) is an anti-viral agent that selectively and potently inhibits the RNA-dependent RNA polymerase…”
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Discovery and development of pyrethroid insecticides by MATSUO, Noritada

“…Pyrethroid insecticides contain natural pyrethrins extracted from pyrethrum flowers, and their synthetic derivatives, pyrethroids. The present article provides…”
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Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer by HATAKEYAMA, Masanori

“…Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor of gastric cancer. The cagA gene-encoded CagA protein is…”
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Importin α: functions as a nuclear transport factor and beyond by OKA, Masahiro, YONEDA, Yoshihiro

“…Nucleocytoplasmic transport is an essential process in eukaryotes. The molecular mechanisms underlying nuclear transport that involve the nuclear transport…”
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Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy by ARAKAWA, Satoko, HONDA, Shinya, YAMAGUCHI, Hirofumi, SHIMIZU, Shigeomi

“…ATG5 and ATG7 are considered to be essential molecules for the induction of autophagy. However, we found that cells lacking ATG5 or ATG7 can still form…”
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Molecular mechanisms of thalidomide and its derivatives by ITO, Takumi, HANDA, Hiroshi

“…Thalidomide, originally developed as a sedative drug, causes multiple defects due to severe teratogenicity, but it has been re-purposed for treating multiple…”
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Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome by FUSAKI, Noemi, BAN, Hiroshi, NISHIYAMA, Akiyo, SAEKI, Koichi, HASEGAWA, Mamoru

“…Induced pluripotent stem cells (iPSC) have been generated from somatic cells by introducing reprogramming factors. Integration of foreign genes into the host…”
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Coronary artery spasm — Clinical features, pathogenesis and treatment by YASUE, Hirofumi, MIZUNO, Yuji, HARADA, Eisaku

“…Coronary artery spasm (CAS) plays an important role in the pathogenesis of ischemic heart disease, including angina pectoris, myocardial infarction, and sudden…”
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The piRNA pathway in Drosophila ovarian germ and somatic cells by SATO, Kaoru, SIOMI, Mikiko C.

“…RNA silencing refers to gene silencing pathways mediated by small non-coding RNAs, including microRNAs. Piwi-interacting RNAs (piRNAs) constitute the largest…”
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Glutamate as intracellular and extracellular signals in pancreatic islet functions by TAKAHASHI, Harumi, YOKOI, Norihide, SEINO, Susumu

“…l -Glutamate is one of the most abundant amino acids in the body and is a constituent of proteins and a substrate in metabolism. It is well known that…”
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The proteasome: Overview of structure and functions by TANAKA, Keiji

“…The proteasome is a highly sophisticated protease complex designed to carry out selective, efficient and processive hydrolysis of client proteins. It is known…”
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RET receptor signaling: Function in development, metabolic disease, and cancer by TAKAHASHI, Masahide

“…The RET proto-oncogene encodes a receptor tyrosine kinase whose alterations are responsible for various human cancers and developmental disorders, including…”
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TNF receptor-associated factor 6 (TRAF6) plays crucial roles in multiple biological systems through polyubiquitination-mediated NF-κB activation by YAMAMOTO, Mizuki, GOHDA, Jin, AKIYAMA, Taishin, INOUE, Jun-ichiro

“…NF-κB was first identified in 1986 as a B cell-specific transcription factor inducing immunoglobulin κ light chain expression. Subsequent studies revealed that…”
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The discovery of Hepatocyte Growth Factor (HGF) and its significance for cell biology, life sciences and clinical medicine by NAKAMURA, Toshikazu, MIZUNO, Shinya

“…It has been more than 25 years since HGF was discovered as a mitogen of hepatocytes. HGF is produced by stromal cells, and stimulates epithelial cell…”
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Synaptic functions and their disruption in schizophrenia: From clinical evidence to synaptic optogenetics in an animal model by OBI-NAGATA, Kisho, TEMMA, Yusuke, HAYASHI-TAKAGI, Akiko

“…The adult human brain consists of approximately a hundred billion neurons, which are connected via synapses. The pattern and strength of the synaptic…”
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A historical perspective on the discovery of statins by ENDO, Akira

“…Cholesterol is essential for the functioning of all human organs, but it is nevertheless the cause of coronary heart disease. Over the course of nearly a…”
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Lipid hydroperoxides in nutrition, health, and diseases by MIYAZAWA, Teruo

“…Research on lipid peroxidation in food degradation, oil and fat nutrition, and age-related diseases has gained significant international attention for the view…”
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Hydrogen sulfide and polysulfides as signaling molecules by KIMURA, Hideo

“…Hydrogen sulfide (H2S) is a familiar toxic gas that smells of rotten eggs. After the identification of endogenous H2S in the mammalian brain two decades ago,…”
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Clinical epidemiology and pharmacoepidemiology studies with real-world databases by YOSHIDA, Satomi, TAKEUCHI, Masato, TANAKA-MIZUNO, Sachiko, MIZUNO, Kayoko, NAKASHIMA, Masayuki, FUKASAWA, Toshiki, KAWAKAMI, Koji

“…Hospital-based registry data, including patients’ information collected by academic societies or government based research groups, were previously used for…”
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Function and mechanisms of memory destabilization and reconsolidation after retrieval by KIDA, Satoshi

“…Memory retrieval is not a passive process. When a memory is retrieved, the retrieved memory is destabilized, similar to short-term memory just after learning,…”
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