Amperometric Biosensor Detecting Dopamine Based on Polypyrrole/Reduced Graphene Oxide/Nickel Oxide/Glassy Carbon Electrode

Amperometric Biosensor Detecting Dopamine Based on Polypyrrole/Reduced Graphene Oxide/Nickel Oxide/Glassy Carbon Electrode

Dopamine (3,4‐dihydroxyphenethylamine) (DA) plays an important role in influencing emotions, pleasure sensations, concentration, pain, and coordination of body movements. However, abnormal levels of DA in the brain can lead to Parkinson’s, Alzheimer’s, or schizophrenia diseases. A biosensor is defin...

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Bibliographic Details
Published in:Journal of electrical and computer engineering Vol. 2024; no. 1
Main Authors: Priyanto, Shindy Ayu Netania, Yulianti, Elly Septia, Zakiyuddin, Ahmad, Rahman, Siti Fauziyah
Format: Journal Article
Language:English
Published: New York Hindawi Limited 24-07-2024
Subjects:
Antibiotics
Biocompatibility
Biosensors
Carbon
Cost analysis
Disease
Dopamine
Electrical measurement
Electrodes
Electrons
Ethanol
Fourier transforms
Glassy carbon
Graphene
Graphite
Nickel oxides
Nitrates
Oxidation
Polypyrroles
Schizophrenia
Sensors
Spectrum analysis
Uric acid
Voltammetry
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Summary:Dopamine (3,4‐dihydroxyphenethylamine) (DA) plays an important role in influencing emotions, pleasure sensations, concentration, pain, and coordination of body movements. However, abnormal levels of DA in the brain can lead to Parkinson’s, Alzheimer’s, or schizophrenia diseases. A biosensor is defined as an analytical tool that combines certain biological recognition components with a physical transducer. A comprehensive study was conducted to enhance the performance of DA detection by incorporating reduced graphene oxide (rGO), polypyrrole (PPy), and nickel oxide (NiO) into the glassy carbon electrode (GCE). DA levels were measured using cyclic voltammetry (CV) with a three‐electrode configuration. Material characterization was evaluated by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The results obtained indicate that PPy/rGO/NiO/GCE has a detection limit of 0.195 mM and a sensitivity of 25.887 A mM −1 cm −2 for a linear range of 0.01–1 mM.
ISSN:2090-0147
2090-0155
DOI:10.1155/2024/7453474