Genotype distribution of Group A rotavirus from southern India, 2005–2016

Diarrheal disease due to Group A rotaviruses remain a leading cause of mortality and morbidity in the less developed parts of the world. India has started a phased roll out of rotavirus vaccine in the national immunization program. This analysis summarizes the rotavirus genotype strain distribution...

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Bibliographic Details
Published in:	Vaccine Vol. 36; no. 51; pp. 7816 - 7819
Main Authors:	Babji, Sudhir, Arumugam, Rajesh, Priyahemavathy, R., Sriraman, Archana, Sarvanabhavan, Anuradha, Manickavasagam, Punithavathy, Simon, Anna, Aggarwal, Indira, Moses, Prabhakar D., Arora, Rashmi, Kang, Gagandeep
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 14-12-2018 Elsevier Limited
Subjects:	Age Antigens, Viral - genetics Capsid Proteins - genetics Child, Preschool Diarrhea Diarrhea - epidemiology Diarrhea - prevention & control Enzyme-Linked Immunosorbent Assay Feces - virology Female Gastroenteritis - epidemiology Gastroenteritis - prevention & control Genetic Variation Genotype Genotype & phenotype Genotypes Humans Immunization Immunization Programs India - epidemiology Infant Infant, Newborn Laboratories Licenses Male Medical research Morbidity Phylogeny RNA, Viral - genetics Rotavirus Rotavirus - genetics Rotavirus epidemiology Rotavirus Infections - diagnosis Rotavirus Infections - epidemiology Rotavirus Vaccines - administration & dosage Seasonal variations Strain distribution Studies Surveillance Tamil Nadu Vaccines Vellore Viruses India Australia Rotavirus epidemiology Vellore Tamil Nadu
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Summary:	Diarrheal disease due to Group A rotaviruses remain a leading cause of mortality and morbidity in the less developed parts of the world. India has started a phased roll out of rotavirus vaccine in the national immunization program. This analysis summarizes the rotavirus genotype strain distribution pre-vaccine introduction in Vellore, India from December 2005 to June 2016. Rotavirus was responsible for 32% of all diarrheal admission to the hospital. G2P[4] was the predominant strain in the initial years and was gradually replaced by G1P[8]. The emergence of G9P[4] replacing G9P[8], and the detection of G12 strains over several years were documented. There was no clear seasonality of disease. These data form the baseline to monitor genotype distribution post-vaccine introduction in Tamil Nadu.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2017.08.035