Search Results - "Priya Doss. C, George"

The role of photosynthesis related pigments in light harvesting, photoprotection and enhancement of photosynthetic yield in planta by Simkin, Andrew J., Kapoor, Leepica, Doss, C. George Priya, Hofmann, Tanja A., Lawson, Tracy, Ramamoorthy, Siva

“…Photosynthetic pigments are an integral and vital part of all photosynthetic machinery and are present in different types and abundances throughout the…”
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Therapeutic miRNA and siRNA: Moving from Bench to Clinic as Next Generation Medicine by Chakraborty, Chiranjib, Sharma, Ashish Ranjan, Sharma, Garima, Doss, C. George Priya, Lee, Sang-Soo

“…In the past few years, therapeutic microRNA (miRNA) and small interfering RNA (siRNA) are some of the most important biopharmaceuticals that are in commercial…”
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Unraveling the Structural Changes in the DNA-Binding Region of Tumor Protein p53 ( TP53 ) upon Hotspot Mutation p53 Arg248 by Comparative Computational Approach by Balasundaram, Ambritha, Doss, C George Priya

“…The vital tissue homeostasis regulator p53 forms a tetramer when it binds to DNA and regulates the genes that mediate essential biological processes such as…”
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Analysis of Differentially Expressed Genes and Molecular Pathways in Familial Hypercholesterolemia Involved in Atherosclerosis: A Systematic and Bioinformatics Approach by Udhaya Kumar, S, Thirumal Kumar, D, Bithia, R, Sankar, Srivarshini, Magesh, R, Sidenna, Mariem, George Priya Doss, C, Zayed, Hatem

“…Familial hypercholesterolemia (FH) is one of the major risk factor for the progression of atherosclerosis and coronary artery disease. This study focused on…”
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Airway and Oral microbiome profiling of SARS-CoV-2 infected asthma and non-asthma cases revealing alterations–A pulmonary microbial investigation by Sekaran, Karthik, Varghese, Rinku Polachirakkal, Doss C., George Priya, Alsamman, Alsamman M, Zayed, Hatem, El Allali, Achraf

“…New evidence strongly discloses the pathogenesis of host-associated microbiomes in respiratory diseases. The microbiome dysbiosis modulates the lung’s behavior…”
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Computational investigation to identify potent inhibitors of the GTPase-Kirsten RAt sarcoma virus (K-Ras) mutants G12C and G12D by Kumar, S. Udhaya, Priya Doss, C. George

“…K-Ras mutations are frequent in various cancer types, and according to recent research, K-Ras possesses four-drug targeting sites. This increased our interest…”
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Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach by P, Sneha, D, Thirumal Kumar, C, George Priya Doss, R, Siva, Zayed, Hatem

“…Maturity-onset diabetes of the young type 3 (MODY3) is a non-ketotic form of diabetes associated with poor insulin secretion. Over the past years, several…”
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Identification of potential inhibitors, conformational dynamics, and mechanistic insights into mutant Kirsten rat sarcoma virus (G13D) driven cancers by Tayubi, Iftikhar A., Kumar S., Udhaya, Doss C., George Priya

“…The mutations at the hotspot region of K‐Ras result in the progression of cancer types. Our study aimed to explore the small molecule inhibitors against the…”
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BSA nanoparticle loaded atorvastatin calcium--a new facet for an old drug by Sripriyalakshmi, S, Anjali, C H, George, Priya Doss C, Rajith, B, Ravindran, Aswathy

“…Currently, the discovery of effective chemotherapeutic agents poses a major challenge to the field of cancer biology. The present study focuses on enhancing…”
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Comparative computational assessment of the pathogenicity of mutations in the Aspartoacylase enzyme by George Priya Doss, C., Zayed, Hatem

“…Aspartoacylase (ASPA) is a zinc-dependent abundant enzyme in the brain, which catalyzes the conversion of N-acetyl aspartate (NAA) into acetate and aspartate…”
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How Precise are Nanomedicines in Overcoming the Blood-Brain Barrier? A Comprehensive Review of the Literature by Mohapatra, Priyadarshini, Gopikrishnan, Mohanraj, Doss C, George Priya, Chandrasekaran, Natarajan

“…New nanotechnology strategies for enhancing drug delivery in brain disorders have recently received increasing attention from drug designers. The treatment of…”
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A profound computational study to prioritize the disease-causing mutations in PRPS1 gene by Agrahari, Ashish Kumar, Sneha, P., George Priya Doss, C., Siva, R., Zayed, Hatem

“…Charcot-Marie-Tooth disease (CMT) is one of the most commonly inherited congenital neurological disorders, affecting approximately 1 in 2500 in the US. About…”
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A Computational Approach to Identify a Potential Alternative Drug With Its Positive Impact Toward PMP22 by Agrahari, Ashish Kumar, C, George Priya Doss

“…ABSTRACT Mutations in the Peripheral Myelin Protein 22 (PMP22) leads to Charcot Marie Tooth type 1A (CMT1A, a subtype of CMT1) disease which is the most common…”
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Analysing the Effect of Mutation on Protein Function and Discovering Potential Inhibitors of CDK4: Molecular Modelling and Dynamics Studies by N, Nagasundaram, Zhu, Hailong, Liu, Jiming, V, Karthick, C, George Priya Doss, Chakraborty, Chiranjib, Chen, Luonan

“…The cyclin-dependent kinase 4 (CDK4)-cyclin D1 complex plays a crucial role in the transition from the G1 phase to S phase of the cell cycle. Among the CDKs,…”
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Evaluation of Supervised Machine Learning Algorithms and Computational Structural Validation of Single Nucleotide Polymorphisms Related to Acute Liver Injury with Paracetamol by Sridharan, Kannan, Balasundaram, Ambritha, Kumar, D Thirumal, Doss, C George Priya

“…To identify single nucleotide polymorphisms (SNPs) of paracetamol-metabolizing enzymes that can predict acute liver injury. Paracetamol is a commonly…”
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Residue interaction networks of K-Ras protein with water molecules identifies the potential role of switch II and P-loop by Kumar, S. Udhaya, Priya Doss, C. George

“…The mutant K-Ras with aberrant signaling is the primary cause of several cancers. The proposed study investigated the influence of water molecules in K-Ras…”
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Molecular dynamics simulations corroborate recombinant expression studies carried out on three αIIb β‐propeller mutations reported in Indian Glanzmann thrombasthenia patients by Chandrasekaran, Finola Priyadharshini, Vishal, Adarsh, Arora, Udita, Kumar S., Udhaya, George C., Priya Doss, Nelson, Everette Jacob Remington

“…Mutations in the αIIb β‐propeller domain have long been known to disrupt heterodimerization and intracellular trafficking of αIIbβ3 complexes leading to…”
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Determination of potential combination of non‐β‐lactam, β‐lactam, and β‐lactamase inhibitors/β‐lactam enhancer against class D oxacillinases producing Acinetobacter baumannii: Evidence from in‐vitro, molecular docking and dynamics simulation by Gopikrishnan, Mohanraj, Ramireddy, Sriroopreddy, Varghese, Rinku Polachirakkal, Bakathavatchalam, Yamuna Devi, D, Thirumal Kumar, Manesh, Abi, Walia, Kamini, Veeraraghavan, Balaji, C, George Priya Doss

“…Carbapenem‐resistant Acinetobacter baumannii, a predominant nosocomial pathogen in hospitals of intensive care units, is associated with bacteremia and…”
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Multi-drug loaded eugenol-based nanoemulsions for enhanced anti-mycobacterial activity by Menon, Parvathy Mohan, Chandrasekaran, Natarajan, C, George Priya Doss, Shanmugam, Sivakumar

“…Tuberculosis is one of the oldest bacterial infections known to mankind caused by Mycobacterium tuberculosis . The aim of this research is to optimize and…”
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Effects of the pathological E200K mutation on human prion protein: A computational screening and molecular dynamics approach by Gharemirshamloo, Fatemeh Rahimi, Majumder, Ranabir, Kumar S., Udhaya, Doss C., George Priya, Bamdad, Kourosh, Frootan, Fateme, Un, Cemal

“…The human prion protein gene (PRNP) is mapped to the short arm of chromosome 20 (20pter‐12). Prion disease is associated with mutations in the prion…”
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