Search Results - "Pritchard, R."

Emulation of reionization simulations for Bayesian inference of astrophysics parameters using neural networks by Schmit, C J, Pritchard, J R

“…Abstract Next generation radio experiments such as LOFAR, HERA, and SKA are expected to probe the Epoch of Reionization (EoR) and claim a first direct…”
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Quantifying the non-Gaussianity in the EoR 21-cm signal through bispectrum by Majumdar, Suman, Pritchard, Jonathan R, Mondal, Rajesh, Watkinson, Catherine A, Bharadwaj, Somnath, Mellema, Garrelt

“…Abstract The epoch of reionization (EoR) 21-cm signal is expected to be highly non-Gaussian in nature and this non-Gaussianity is also expected to evolve with…”
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A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress by Bruno, Peter M, Liu, Yunpeng, Park, Ga Young, Murai, Junko, Koch, Catherine E, Eisen, Timothy J, Pritchard, Justin R, Pommier, Yves, Lippard, Stephen J, Hemann, Michael T

“…Whereas cisplatin and carboplatin kill cancer cells by inducing DNA damage, another platinum derivative, oxaliplatin, induces cell death by triggering ribosome…”
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The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning by Bruno, Peter M., Lu, Mengrou, Dennis, Kady A., Inam, Haider, Moore, Connor J., Sheehe, John, Elledge, Stephen J., Hemann, Michael T., Pritchard, Justin R.

“…Small molecules can affect many cellular processes. The disambiguation of these effects to identify the causative mechanisms of cell death is extremely…”
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Global forest restoration and the importance of prioritizing local communities by Erbaugh, J. T., Pradhan, N., Adams, J., Oldekop, J. A., Agrawal, A., Brockington, D., Pritchard, R., Chhatre, A.

“…Forest restoration occupies centre stage in global conversations about carbon removal and biodiversity conservation, but recent research rarely acknowledges…”
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Redshifted 21-cm bispectrum – I. Impact of the redshift space distortions on the signal from the Epoch of Reionization by Majumdar, Suman, Kamran, Mohd, Pritchard, Jonathan R, Mondal, Rajesh, Mazumdar, Arindam, Bharadwaj, Somnath, Mellema, Garrelt

“…ABSTRACT The bispectrum can quantify the non-Gussianity present in the redshifted 21-cm signal produced by the neutral hydrogen ($\rm {H \small {I}}$) during…”
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The impact of spin-temperature fluctuations on the 21-cm moments by Watkinson, C. A., Pritchard, J. R.

“…This paper considers the impact of Lyman α coupling and X-ray heating on the 21-cm brightness-temperature one-point statistics (as predicted by seminumerical…”
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The 21-cm bispectrum as a probe of non-Gaussianities due to X-ray heating by Watkinson, Catherine A, Giri, Sambit K, Ross, Hannah E, Dixon, Keri L, Iliev, Ilian T, Mellema, Garrelt, Pritchard, Jonathan R

“…We present analysis of the normalized 21-cm bispectrum from fully-numerical simulations of intergalactic-medium heating by stellar sources and high-mass X-ray…”
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Distinguishing models of reionization using future radio observations of 21-cm 1-point statistics by Watkinson, C. A., Pritchard, J. R.

“…We explore the impact of reionization topology on 21-cm statistics. Four reionization models are presented which emulate large ionized bubbles around overdense…”
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Electrochemotherapy in the treatment of cutaneous malignancy: Outcomes and subgroup analysis from the cumulative results from the pan-European International Network for Sharing Practice in Electrochemotherapy database for 2482 lesions in 987 patients (2008–2019) by Clover, A.J.P., de Terlizzi, F., Bertino, G., Curatolo, P., Odili, J., Campana, L.G., Kunte, C., Muir, T., Brizio, M., Sersa, G., Pritchard Jones, R., Moir, G., Orlando, A., Banerjee, S.M., Kis, E., McCaul, J.A., Grischke, E.M., Matteucci, P., Mowatt, D., Bechara, F.G., Mascherini, M., Lico, V., Giorgione, R., Seccia, V., Schepler, H., Pecorari, G., MacKenzie Ross, A.D., Bisase, B., Gehl, J.

“…Electrochemotherapy (ECT) is a treatment for both primary and secondary cutaneous tumours. The international Network for sharing practices on ECT group…”
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Evolution of the nonsense-mediated decay pathway is associated with decreased cytolytic immune infiltration by Zhao, Boyang, Pritchard, Justin R

“…The somatic co-evolution of tumors and the cellular immune responses that combat them drives the diversity of immune-tumor interactions. This includes tumor…”
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21-cm fluctuations from inhomogeneous X-ray heating before reionization by Pritchard, Jonathan R., Furlanetto, Steven R.

“…Many models of early structure formation predict a period of heating immediately preceding reionization, when X-rays raise the gas temperature above that of…”
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ARTIST: high-resolution genome-wide assessment of fitness using transposon-insertion sequencing by Pritchard, Justin R, Chao, Michael C, Abel, Sören, Davis, Brigid M, Baranowski, Catherine, Zhang, Yanjia J, Rubin, Eric J, Waldor, Matthew K

“…Transposon-insertion sequencing (TIS) is a powerful approach for deciphering genetic requirements for bacterial growth in different conditions, as it enables…”
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Redshifted 21-cm bispectrum – II. Impact of the spin temperature fluctuations and redshift space distortions on the signal from the Cosmic Dawn by Kamran, Mohd, Ghara, Raghunath, Majumdar, Suman, Mondal, Rajesh, Mellema, Garrelt, Bharadwaj, Somnath, Pritchard, Jonathan R, Iliev, Ilian T

“…ABSTRACT We present a study of the 21-cm signal bispectrum (which quantifies the non-Gaussianity in the signal) from the Cosmic Dawn (CD). For our analysis, we…”
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Inherited Disease Genetics Improves the Identification of Cancer-Associated Genes by Zhao, Boyang, Pritchard, Justin R

“…The identification of biologically significant variants in cancer genomes is critical to therapeutic discovery, but it is limited by the statistical power…”
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Rural suicide in Newfoundland and Labrador: A qualitative exploration of health care providers' perspectives by Pritchard, Tyler R, Buckle, Jennifer L, Thomassin, Kristel, Lewis, Stephen P

“…Residents of rural regions may have higher and unique suicide risks. Newfoundland and Labrador (NL) is a Canadian province replete with rural regions. Despite…”
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Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution by Zhao, Boyang, Sedlak, Joseph C., Srinivas, Raja, Creixell, Pau, Pritchard, Justin R., Tidor, Bruce, Lauffenburger, Douglas A., Hemann, Michael T.

“…The prevailing approach to addressing secondary drug resistance in cancer focuses on treating the resistance mechanisms at relapse. However, the dynamic nature…”
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Increased miR-132-3p expression is associated with chronic neuropathic pain by Leinders, M., Üçeyler, N., Pritchard, R.A., Sommer, C., Sorkin, L.S.

“…Alterations in the neuro-immune balance play a major role in the pathophysiology of chronic neuropathic pain. MicroRNAs (miRNA) can regulate both immune and…”
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Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform by Rock, Jeremy M., Hopkins, Forrest F., Chavez, Alejandro, Diallo, Marieme, Chase, Michael R., Gerrick, Elias R., Pritchard, Justin R., Church, George M., Rubin, Eric J., Sassetti, Christopher M., Schnappinger, Dirk, Fortune, Sarah M.

“…The development of new drug regimens that allow rapid, sterilizing treatment of tuberculosis has been limited by the complexity and time required for genetic…”
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Defining principles of combination drug mechanisms of action by Pritchard, Justin R, Bruno, Peter M, Gilbert, Luke A, Capron, Kelsey L, Lauffenburger, Douglas A, Hemann, Michael T

“…Combination chemotherapies have been a mainstay in the treatment of disseminated malignancies for almost 60 y, yet even successful regimens fail to cure many…”
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