Search Results - "Pritchard, Harry A.T."

The angiotensin II receptor type 1b is the primary sensor of intraluminal pressure in cerebral artery smooth muscle cells by Pires, Paulo W., Ko, Eun‐A., Pritchard, Harry A.T., Rudokas, Michael, Yamasaki, Evan, Earley, Scott

“…Key points The angiotensin II receptor type 1b (AT1Rb) is the primary sensor of intraluminal pressure in cerebral arteries. Pressure or membrane‐stretch…”
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Cardiovascular comorbidities, inflammation, and cerebral small vessel disease by Evans, Lowri E, Taylor, Jade L, Smith, Craig J, Pritchard, Harry A T, Greenstein, Adam S, Allan, Stuart M

“…Abstract Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive impairment and affects all levels of the brain’s vasculature…”
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Cerebral Capillary TRPA1 Channels Mediate Functional Hyperemia via Retrograde Conducted Vasodilation by Pires, Paulo Wagner, Pritchard, Harry A.T., Earley, Scott

“…Cerebral capillaries are the sites of nutrient exchange and removal of metabolic by‐products within the brain parenchyma. Recent studies showed that cerebral…”
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Acute, pro‐contractile effects of prorenin on rat mesenteric arteries by Rognant, Salomé, Baldwin, Samuel N., Pritchard, Harry A. T., Greenstein, Adam, Calloe, Kirstine, Aalkjaer, Christian, Jepps, Thomas A.

“…Prorenin and the prorenin receptor ((P)RR) are important, yet controversial, members of the renin–angiotensin–aldosterone system. The ((P)RR) is expressed…”
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Nanoscale remodeling of ryanodine receptor cluster size underlies cerebral microvascular dysfunction in Duchenne muscular dystrophy by Pritchard, Harry A. T., Pires, Paulo W., Yamasaki, Evan, Thakore, Pratish, Earley, Scott

“…Duchenne muscular dystrophy (DMD) results from mutations in the gene encoding dystrophin which lead to impaired function of skeletal and cardiac muscle, but…”
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Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility by Pritchard, Harry A. T., Griffin, Caoimhin S., Yamasaki, Evan, Thakore, Pratish, Lane, Conor, Greenstein, Adam S., Earley, Scott

“…Junctophilin proteins maintain close contacts between the endoplasmic/sarcoplasmic reticulum (ER/SR) and the plasma membrane in many types of cells, as…”
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Functionally linked potassium channel activity in cerebral endothelial and smooth muscle cells is compromised in Alzheimer’s disease by Taylor, Jade L., Pritchard, Harry A. T., Walsh, Katy R., Strangward, Patrick, White, Claire, Hill-Eubanks, David, Alakrawi, Mariam, Hennig, Grant W., Allan, Stuart M., Nelson, Mark T., Greenstein, Adam S.

“…The brain microcirculation is increasingly viewed as a potential target for disease-modifying drugs in the treatment of Alzheimer’s disease patients,…”
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Brain endothelial cell TRPA1 channels initiate neurovascular coupling by Thakore, Pratish, Alvarado, Michael G, Ali, Sher, Mughal, Amreen, Pires, Paulo W, Yamasaki, Evan, Pritchard, Harry At, Isakson, Brant E, Tran, Cam Ha T, Earley, Scott

“…Cerebral blood flow is dynamically regulated by neurovascular coupling to meet the dynamic metabolic demands of the brain. We hypothesized that TRPA1 channels…”
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Kynurenine Relaxes Arteries of Normotensive Women and Those With Preeclampsia by Worton, Stephanie A., Pritchard, Harry A.T., Greenwood, Susan L., Alakrawi, Mariam, Heazell, Alexander E.P., Wareing, Mark, Greenstein, Adam, Myers, Jenny E.

“…[Figure: see text]…”
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Uncoupling of Ca2+ sparks from BK channels in cerebral arteries underlies hypoperfusion in hypertension-induced vascular dementia by Taylor, Jade L, Walsh, Katy R, Mosneag, Ioana-Emilia, Danby, Thea G E, Luka, Nadim, Chanda, Bishal, Schiessl, Ingo, Dunne, Ross A, Hill-Eubanks, David, Hennig, Grant W, Allan, Stuart M, Nelson, Mark T, Greenstein, Adam S, Pritchard, Harry A T

“…There are no treatments available for vascular dementia, the second-most common dementia syndrome, and patients decline rapidly after diagnosis. This syndrome…”
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Junctophilin‐2 Supports Functional Coupling Between Type 2 Ryanodine Receptors and BK Channels in Vascular Smooth Muscle Cells by Yamasaki, Evan, Pritchard, Harry A.T., Pires, Paulo W., Earley, Scott

“…Junctophilin‐2 (JPH2) is a structural protein that tethers the sarcoplasmic reticulum (SR) to the plasma membrane (PM) within the cardiac dyad. JPH2 is vital…”
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Potent vasorelaxant activity of the TMEM16A inhibitor T16A inh ‐A01 by Davis, Alison J, Shi, Jian, Pritchard, Harry AT, Chadha, Preet S, Leblanc, Normand, Vasilikostas, Georgios, Yao, Zhen, Verkman, AS, Albert, Anthony P, Greenwood, Iain A

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TRPML1‐Mediated Ca 2+ Signaling in Cerebral Artery Smooth Muscle by Lane, Conor P, Pritchard, Harry A.T, Drumm, Bernard T, Sanders, Kenton M, Earley, Scott

“…Abstract only Late endosomes and lysosomes (collectively referred to as endolysosomes) are small acidic organelles present in all cells that maintain a steep…”
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Microtubule structures underlying the sarcoplasmic reticulum support peripheral coupling sites to regulate smooth muscle contractility by Pritchard, Harry A T, Gonzales, Albert L, Pires, Paulo W, Drumm, Bernard T, Ko, Eun A, Sanders, Kenton M, Hennig, Grant W, Earley, Scott

“…Junctional membrane complexes facilitate excitation-contraction coupling in skeletal and cardiac muscle cells by forming subcellular invaginations that…”
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Inhibitory Role of PIP2 on Calcium-Activated Chloride Channel Activity by Pritchard, Harry A.T., Albert, Anthony P., Leblanc, Normand, Greenwood, Iain A.

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A Multi-disciplinary Commentary on Preclinical Research to investigate Vascular Contributions to Dementia by Sri, Sarmi, Greenstein, Adam, Granata, Alessandra, Collcutt, Alex, Jochems, Angela C C, McColl, Barry W, Castro, Blanca Díaz, Webber, Caleb, Reyes, Carmen Arteaga, Hall, Catherine, Lawrence, Catherine B, Hawkes, Cheryl, Pegasiou-Davies, Chrysia-Maria, Gibson, Claire, Crawford, Colin, Smith, Colin, Vivien, Denis, McLean, Fiona H, Wiseman, Frances, Brezzo, Gaia, Lalli, Giovanna, Pritchard, Harry A T, Markus, Hugh S, Bravo-Ferrer, Isabel, Taylor, Jade, Leiper, James, Berwick, Jason, Gan, Jian, Gallacher, John, Moss, Jonathan, Goense, Jozien, McMullan, Letitia, Work, Lorraine, Evans, Lowri, Stringer, Michael S, Ashford, MLJ, Abulfadl, Mohamed, Conlon, Nina, Malhotra, Paresh, Bath, Philip, Canter, Rebecca, Brown, Rosalind, Ince, Selvi, Anderle, Silvia, Young, Simon, Quick, Sophie, Szymkowiak, Stefan, Hill, Steve, Allan, Stuart, Wang, Tao, Quinn, Terry, Procter, Tessa, Farr, Tracy D, Zhao, Xiangjun, Yang, Zhiyuan, Hainsworth, Atticus H, Wardlaw, Joanna M

“…•Different models recapitulate different aspects of human SVD – the right model should be used to answer the right question•Successful translation requires…”
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Molecular and functional significance of Ca(2+)-activated Cl(-) channels in pulmonary arterial smooth muscle by Leblanc, Normand, Forrest, Abigail S, Ayon, Ramon J, Wiwchar, Michael, Angermann, Jeff E, Pritchard, Harry A T, Singer, Cherie A, Valencik, Maria L, Britton, Fiona, Greenwood, Iain A

“…Increased peripheral resistance of small distal pulmonary arteries is a hallmark signature of pulmonary hypertension (PH) and is believed to be the consequence…”
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“A Step and a Ceiling”: mechanical properties of Ca2+ spark vasoregulation in resistance arteries by pressure‐induced oxidative activation of PKG by Csato, Viktoria, Kadir, Sharifah Z. S. A., Khavandi, Kaivan, Bennett, Hayley, Sugden, Sarah, Gurney, Alison M., Pritchard, Harry T., Hill‐Eubanks, David, Eaton, Philip, Nelson, Mark T., Greenstein, Adam S.

“…We investigated the biomechanical relationship between intraluminal pressure within small mesenteric resistance arteries, oxidant activation of PKG, Ca2+…”
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