Search Results - "Pritchard, D. M."

Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease by Kiesslich, R, Duckworth, C A, Moussata, D, Gloeckner, A, Lim, L G, Goetz, M, Pritchard, D M, Galle, P R, Neurath, M F, Watson, A J M

“…Loss of intestinal barrier function plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Shedding of intestinal epithelial cells is…”
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Review article: cellular and molecular mechanisms of NSAID‐induced peptic ulcers by MUSUMBA, C., PRITCHARD, D. M., PIRMOHAMED, M.

“…Summary Background  Nonsteroidal anti‐inflammatory drugs (NSAIDs) are some of the most prescribed drugs worldwide and have now probably overtaken Helicobacter…”
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Review article: pathogenesis and management of gastric carcinoid tumours by BURKITT, M. D., PRITCHARD, D. M.

“…Summary Background Gastric carcinoid tumours are rare, but are increasing in incidence. Aim To discuss tumour pathogenesis and outline current approaches to…”
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Circulating galectins -2, -4 and -8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis by Chen, C, Duckworth, C A, Fu, B, Pritchard, D M, Rhodes, J M, Yu, L-G

“…Background: Circulating concentrations of the cytokines interleukin-6 (IL-6), granulocyte colony-stimulating factor (G-CSF) and chemokines monocyte chemotatic…”
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Mouse organoids as an in vitro tool to study the in vivo intestinal response to cytotoxicants by Jardi, F., Kelly, C., Teague, C., Fowler-Williams, H., Sevin, D. C., Rodrigues, D., Jo, H., Ferreira, S., Herpers, B., Van Heerden, M., de Kok, T., Pin, C., Lynch, A., Duckworth, C. A., De Jonghe, S., Lammens, L., Pritchard, D. M.

“…Cross-species comparison of drug responses at the organoid level could help to determine the human relevance of findings from animal studies. To this end, we…”
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Serial surveillance of carcinoid heart disease: factors associated with echocardiographic progression and mortality by Dobson, R, Burgess, M I, Valle, J W, Pritchard, D M, Vora, J, Wong, C, Chadwick, C, Keevi, B, Adaway, J, Hofmann, U, Poston, G J, Cuthbertson, D J

“…Background: Carcinoid heart disease is a complication of metastatic neuroendocrine tumours (NETs). We sought to identify factors associated with…”
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The relative contribution of NSAIDs and Helicobacter pylori to the aetiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hospital in the UK between 2005 and 2010 by Musumba, C., Jorgensen, A., Sutton, L., Van Eker, D., Moorcroft, J., Hopkins, M., Pritchard, D. M., Pirmohamed, M.

“…Summary Background Recent data from Western countries indicate that the aetiology of peptic ulcer disease (PUD) is changing as the prevalence of Helicobacter…”
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The clinical presentation and management of carcinoid heart disease by Dobson, R, Burgess, M.I, Pritchard, D.M, Cuthbertson, D.J

“…Abstract Carcinoid heart disease is a major cause of morbidity and mortality in patients with metastatic neuroendocrine tumours (NETs). Although cases of…”
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Review article: strategies to determine whether hypergastrinaemia is due to Zollinger–Ellison syndrome rather than a more common benign cause by MURUGESAN, S. V. M., VARRO, A., PRITCHARD, D. M.

“…Summary Background  As there is considerable overlap between the fasting serum gastrin concentrations found in Zollinger–Ellison syndrome and various common…”
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CYP2C1917 Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease by Musumba, C O, Jorgensen, A, Sutton, L, Van Eker, D, Zhang, E, O'Hara, N, Carr, D F, Pritchard, D M, Pirmohamed, M

“…Single‐nucleotide polymorphisms (SNPs) in the CYP2C gene cluster have been extensively investigated as predisposing factors for nonsteroidal anti‐inflammatory…”
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Epithelial Cell Shedding and Barrier Function: A Matter of Life and Death at the Small Intestinal Villus Tip by Williams, J. M., Duckworth, C. A., Burkitt, M. D., Watson, A. J. M., Campbell, B. J., Pritchard, D. M.

“…The intestinal epithelium is a critical component of the gut barrier. Composed of a single layer of intestinal epithelial cells (IECs) held together by tight…”
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The stomach in health and disease by Hunt, R H, Camilleri, M, Crowe, S E, El-Omar, E M, Fox, J G, Kuipers, E J, Malfertheiner, P, McColl, K E L, Pritchard, D M, Rugge, M, Sonnenberg, A, Sugano, K, Tack, J

“…The stomach is traditionally regarded as a hollow muscular sac that initiates the second phase of digestion. Yet this simple view ignores the fact that it is…”
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Review article: how useful are the rodent animal models of gastric adenocarcinoma? by PRITCHARD, D. M, PRZEMECK, S. M. C

“…Gastric cancer is the second most common cause of cancer-related mortality world-wide. In most cases, it develops via the pre-malignant stages of atrophic…”
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Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine by PRITCHARD, D. M, PRINT, C, O'REILLY, L, ADAMS, J. M, POTTEN, C. S, HICKMAN, J. A

“…The potential role of the bcl-2 relative bcl-w as a physiological regulator of apoptosis in intestinal epithelia has been investigated. Immunoblots for bcl-w…”
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Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2 by Przemeck, S M C, Duckworth, C A, Pritchard, D M

“…Unlike the small intestine and colon where gamma-radiation-induced apoptosis has previously been well characterized, the response of murine gastric epithelium…”
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Letter: gastric cancer and pernicious anaemia – only a minority of UK pernicious anaemia patients have had a gastroscopy by Pritchard, D. M., Hooper, M.

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Hypergastrinemia increases gastric epithelial susceptibility to apoptosis by PRZEMECK, S. M. C, VARRO, A, BERRY, D, STEELE, I, WANG, T. C, DOCKRAY, G. J, PRITCHARD, D. M

“…Plasma concentrations of the hormone gastrin are elevated by Helicobacter pylori infection and by gastric atrophy. It has previously been proposed that gastrin…”
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COOH-terminal 26-amino acid residues of progastrin are sufficient for stimulation of mitosis in murine colonic epithelium in vivo by Ottewell, P D, Varro, A, Dockray, G J, Kirton, C M, Watson, A J M, Wang, T C, Dimaline, R, Pritchard, D M

“…Transgenic mice (hGAS) that overexpress human progastrin are more susceptible than wild-type mice (FVB/N) to the induction of colonic aberrant crypt foci (ACF)…”
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Altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine Helicobacter infection by Bodger, K, Ahmed, S, Pazmany, L, Pritchard, D M, Micheal, A, Khan, A L, Dimaline, R, Dockray, G J, Varro, A

“…Matrix metalloproteinases (MMPs) have roles in inflammation and other processes relevant to the architectural disturbances seen in the gastric mucosa in…”
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The intestinal epithelial stem cell: the mucosal governor by POTTEN, CHRISTOPHER S., BOOTH, CATHERINE, PRITCHARD, D. MARK

“…All epithelial cells in the small and large intestine are thought to originate from stem cells located towards the base of the crypts of Lieberkühn. To‐date,…”
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