The Birmingham and Black Country cohort of Venous Thromboembolism (BBC-VTE) registry: Rationale, design and preliminary results

•The Birmingham Black Country Venous Thromboembolism registry (BBC-VTE) is a modern and multi-ethnic cohort of patients who suffered a first episode of VTE.•Our study aims to collect contemporary data on outcomes including mortality, bleeding and VTE recurrence. In addition, the vast scope of data c...

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Published in:	European journal of internal medicine Vol. 97; pp. 50 - 55
Main Authors:	Sanders, Alexander, El-Bouri, Wahbi K., Lip, Gregory Y.H., Clarke, Eleanor E., Clements, Rachel, Roberts, James M., Rai, Simerjit, Binfield, Natalie R., Adewusi, Oluwabamise, Aziz, Sumaiya, Durston, Jennifer, Zathar, Zafraan, Bell, Matthew T., Priskorn, Frederik, Karunatilleke, Anne S., Madzima, Tariro, Illango, Abitha M., Mujong, Datapwa P., Khan, Farishta, Misra, Sannidhya, Dyson, Stephanie J., Edwards, Lloyd, Castle, Alice, Un, Elena A.Y.L., Choudhury, Radia, Penrose, Rachael K., Leeming, Michael P., Chander, Gurvin, Oakley, Callum, Olley, Benjamin M.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-03-2022
Subjects:	Anticoagulants Hemorrhage - etiology Humans Pulmonary Embolism - epidemiology Registries Retrospective Studies Risk Factors Venous Thromboembolism - complications
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Summary:	•The Birmingham Black Country Venous Thromboembolism registry (BBC-VTE) is a modern and multi-ethnic cohort of patients who suffered a first episode of VTE.•Our study aims to collect contemporary data on outcomes including mortality, bleeding and VTE recurrence. In addition, the vast scope of data collection captures many other variables including: location of pulmonary embolism or DVT, detailed lists of co-morbidities, d-dimer values and other laboratory results, previous malignancy and its recurrence, type and duration of anticoagulant used as well as the subsequent site of any bleeding, whether thrombolysis was administered, and of course survival and cause of death where available.•In addition, these data will allow us to conduct machine learning analyses for risk prediction and to compare to previously derived mortality scores such as the PESI. The Birmingham Black Country Venous Thromboembolism registry (BBC-VTE) is a multi-ethnic cohort of patients who suffered a first episode of venous thromboembolism (VTE) and were admitted to various hospital sites across the West Midlands and Black Country regions in the United Kingdom. The BBC-VTE registry is a retrospective, observational cohort study which aims to collect data on outcomes including mortality, bleeding and VTE recurrence in this patient cohort. In addition, the comprehensive, structured data collected will allow us to conduct machine learning analyses for risk prediction in such patients and also to compare to previously derived mortality scores such as the PESI and the simplified PESI (sPESI). Our registry included 2183 patients admitted to hospital between the years 2012–14 and 2016–18 with a first episode of VTE and the mean follow up was 36 months. The cohort was ethnically diverse with 72.5% white Caucasian, 8.2% Asian (including South Asian), 6.7% black, and 11.7% of unknown/other ethnicity. Of those admitted during the collection period 56% had PE, 40% had DVT, with the rest presenting with both PE and DVT. Around 7% of patients went on to develop a bleeding episode and 36% died (all-cause mortality). Of the deaths, 10% of patients died within 30-days of admission (30-day mortality), with 16% dying within 90 days. In summary, this study investigates real-world outcomes of patients after the first index VTE event and attempts to bridge the gap in evidence for contemporary data in this population which will allow to construct more accurate risk prediction tools and management decisions.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	0953-6205 1879-0828
DOI:	10.1016/j.ejim.2022.01.022