Search Results - "Prior, Stephen H"

Charge-Triggered Membrane Insertion of Matrix Metalloproteinase-7, Supporter of Innate Immunity and Tumors by Prior, Stephen H., Fulcher, Yan G., Koppisetti, Rama K., Jurkevich, Alexander, Van Doren, Steven R.

“…Matrix metalloproteinase-7 (MMP-7) sheds signaling proteins from cell surfaces to activate bacterial killing, wound healing, and tumorigenesis. The mechanism…”
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Absence of Tapasin Alters Immunodominance against a Lymphocytic Choriomeningitis Virus Polytope by Boulanger, Denise S. M, Oliveira, Roberta, Ayers, Lisa, Prior, Stephen H, James, Edward, Williams, Anthony P, Elliott, Tim

“…Tapasin edits the peptide repertoire presented to CD8(+) T cells by favoring loading of slow off-rate peptides on MHC I molecules. To investigate the role of…”
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Design and Syntheses of Highly Potent Teixobactin Analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in Vitro and in Vivo by Parmar, Anish, Lakshminarayanan, Rajamani, Iyer, Abhishek, Mayandi, Venkatesh, Leng Goh, Eunice Tze, Lloyd, Daniel G, Chalasani, Madhavi Latha S, Verma, Navin K, Prior, Stephen H, Beuerman, Roger W, Madder, Annemieke, Taylor, Edward J, Singh, Ishwar

“…The cyclic depsipeptide, teixobactin, kills a number of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and Mycobacterium…”
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Efficient total syntheses and biological activities of two teixobactin analogues by Parmar, Anish, Iyer, Abhishek, Vincent, Charlotte S, Van Lysebetten, Dorien, Prior, Stephen H, Madder, Annemieke, Taylor, Edward J, Singh, Ishwar

“…The discovery of the new antibiotic teixobactin has been timely in the race for unearthing novel antibiotics wherein the emergence of drug resistant bacteria…”
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Development of teixobactin analogues containing hydrophobic, non-proteogenic amino acids that are highly potent against multidrug-resistant bacteria and biofilms by Parmar, Anish, Lakshminarayanan, Rajamani, Iyer, Abhishek, Goh, Eunice Tze Leng, To, Tsz Ying, Yam, Joey Kuok Hoong, Yang, Liang, Newire, Enas, Robertson, Maria C., Prior, Stephen H., Breukink, Eefjan, Madder, Annemieke, Singh, Ishwar

“…Teixobactin is a cyclic undecadepsipeptide that has shown excellent potency against multidrug-resistant pathogens, such as methicillin-resistant Staphylococcus…”
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Design and Structure of Stapled Peptides Binding to Estrogen Receptors by Phillips, Chris, Roberts, Lee R, Schade, Markus, Bazin, Richard, Bent, Andrew, Davies, Nichola L, Moore, Rob, Pannifer, Andrew D, Pickford, Andrew R, Prior, Stephen H, Read, Christopher M, Scott, Andrew, Brown, David G, Xu, Bin, Irving, Stephen L

“…Synthetic peptides that specifically bind nuclear hormone receptors offer an alternative approach to small molecules for the modulation of receptor signaling…”
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Syntheses of potent teixobactin analogues against methicillin-resistant Staphylococcus aureus (MRSA) through the replacement of l-allo-enduracididine with its isosteres by Parmar, Anish, Iyer, Abhishek, Lloyd, Daniel G, Vincent, Charlotte S, Prior, Stephen H, Madder, Annemieke, Taylor, Edward J, Singh, Ishwar

“…The recently discovered cyclic depsipeptide, teixobactin, is a highly potent antibiotic against multi-drug resistant pathogens such as methicillin-resistant…”
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Rational design of a cyclohexanone dehydrogenase for enhanced α,β-desaturation and substrate specificity by Singh, Warispreet, Brown, Nicola L, McCue, Hannah V, Marriott, Sophie R, Wilson, Richard C, Perry, Justin, Turkenburg, Johan P, Dubey, Kshatresh D, Prior, Stephen H, Carnell, Andrew J, Taylor, Edward J, Black, Gary W

“…The selective α,β-desaturation of cyclic carbonyl compounds, which are found in the core of many steroid and bioactive molecules, using green chemistry is…”
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Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding by Parmar, Anish, Iyer, Abhishek, Prior, Stephen H, Lloyd, Daniel G, Leng Goh, Eunice Tze, Vincent, Charlotte S, Palmai-Pallag, Timea, Bachrati, Csanad Z, Breukink, Eefjan, Madder, Annemieke, Lakshminarayanan, Rajamani, Taylor, Edward J, Singh, Ishwar

“…Teixobactin is a highly promising antibacterial depsipeptide consisting of four d-amino acids and a rare l- -enduracididine amino acid. l- -Enduracididine is…”
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Ambidextrous binding of cell and membrane bilayers by soluble matrix metalloproteinase-12 by Koppisetti, Rama K., Fulcher, Yan G., Jurkevich, Alexander, Prior, Stephen H., Xu, Jia, Lenoir, Marc, Overduin, Michael, Van Doren, Steven R.

“…Matrix metalloproteinases (MMPs) regulate tissue remodelling, inflammation and disease progression. Some soluble MMPs are inexplicably active near cell…”
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Glycan Activation of a Sheddase: Electrostatic Recognition between Heparin and proMMP-7 by Fulcher, Yan G., Prior, Stephen H., Masuko, Sayaka, Li, Lingyun, Pu, Dennis, Zhang, Fuming, Linhardt, Robert J., Van Doren, Steven R.

“…Heparan sulfate proteoglycans activate the matrix metalloproteinase-7 zymogen (proMMP-7) and recruit it in order to shed proteins from cell surfaces. This…”
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The Interface between Catalytic and Hemopexin Domains in Matrix Metalloproteinase-1 Conceals a Collagen Binding Exosite by Arnold, Laurence H., Butt, Louise E., Prior, Stephen H., Read, Christopher M., Fields, Gregg B., Pickford, Andrew R.

“…Matrix metalloproteinase-1 (MMP-1) is an instigator of collagenolysis, the catabolism of triple helical collagen. Previous studies have implicated its…”
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Path to Collagenolysis: COLLAGEN V TRIPLE-HELIX MODEL BOUND PRODUCTIVELY AND IN ENCOUNTERS BY MATRIX METALLOPROTEINASE-12 by Prior, Stephen H, Byrne, Todd S, Tokmina-Roszyk, Dorota, Fields, Gregg B, Van Doren, Steven R

“…Collagenolysis is essential in extracellular matrix homeostasis, but its structural basis has long been shrouded in mystery. We have developed a novel docking…”
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Characterization of Human Angiogenin Variants Implicated in Amyotrophic Lateral Sclerosis by Crabtree, Benedict, Thiyagarajan, Nethaji, Prior, Stephen H, Wilson, Peter, Iyer, Shalini, Ferns, Tyrone, Shapiro, Robert, Brew, Keith, Subramanian, Vasanta, Acharya, K. Ravi

“…Human angiogenin (ANG), the first member of the angiogenin family (from the pancreatic ribonuclease A superfamily) to be identified, is an angiogenic factor…”
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Ribonuclease A Homologues of the Zebrafish: Polymorphism, Crystal Structures of Two Representatives and their Evolutionary Implications by Kazakou, Konstantina, Holloway, Daniel E., Prior, Stephen H., Subramanian, Vasanta, Acharya, K. Ravi

“…The widespread and functionally varied members of the ribonuclease A (RNase A) superfamily provide an excellent opportunity to study evolutionary forces at…”
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Chemical shift assignments of domain 4 from the phosphohexomutase from Pseudomonas aeruginosa suggest that freeing perturbs its coevolved domain interface by Wei, Yirui, Marcink, Thomas C., Xu, Jia, Sirianni, Arthur G., Sarma, Akella V. S., Prior, Stephen H., Beamer, Lesa J., Van Doren, Steven R.

“…A domain needed for the catalytic efficiency of an enzyme model of simple processivity and domain–domain interactions has been characterized by NMR. This…”
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Path to Collagenolysis by Prior, Stephen H., Byrne, Todd S., Tokmina-Roszyk, Dorota, Fields, Gregg B., Van Doren, Steven R.

“…Collagenolysis is essential in extracellular matrix homeostasis, but its structural basis has long been shrouded in mystery. We have developed a novel docking…”
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Transient Interactions of Metalloproteinases with Bilayers, Captured by Paramagnetic NMR, Include Dual Modes of Binding, Electrostatic Recruiting, and Allostery by Van Doren, Steven R., Prior, Stephen H., Fulcher, Yan G., Xu, Jia, Marcink, Tara C., Koppisetti, Rama K.

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Supramolecular layers and versatile packing modes: The solid state behavior of ortho, ortho-linked bisphenols by Augustin, André U., Katzsch, Felix, Prior, Stephen H., Gruber, Tobias

“…A series of ortho-ortho-linked bisphenols featuring electron-withdrawing groups (EWGs) attached to the phenolic rings is reported. Their respective molecular…”
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Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II bindingElectronic supplementary information (ESI) available: Peptide synthesis, HPLC, LC-MS analysis, NMR spectra, microbiological data (MIC, MBC, time kill kinetics), lipid II and geranyl pyrophosphate binding, cytotoxicity assay. See DOI: 10.1039/c7sc03241b by Parmar, Anish, Iyer, Abhishek, Prior, Stephen H, Lloyd, Daniel G, Leng Goh, Eunice Tze, Vincent, Charlotte S, Palmai-Pallag, Timea, Bachrati, Csanad Z, Breukink, Eefjan, Madder, Annemieke, Lakshminarayanan, Rajamani, Taylor, Edward J, Singh, Ishwar

“…Teixobactin is a highly promising antibacterial depsipeptide consisting of four d -amino acids and a rare l - allo -enduracididine amino acid. l - allo…”
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