Search Results - "Prinz, Heino"

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation by Zychlinsky, Arturo, Waldmann, Herbert, Hakkim, Abdul, Fuchs, Tobias A, Martinez, Nancy E, Hess, Simone, Prinz, Heino

“…The signaling mechanisms leading to the formation of neutrophil extracellular traps (NETs), relevant in infections, sepsis and autoimmune diseases, are poorly…”
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Accelerated disassembly of IgE–receptor complexes by a disruptive macromolecular inhibitor by Kim, Beomkyu, Eggel, Alexander, Tarchevskaya, Svetlana S., Vogel, Monique, Prinz, Heino, Jardetzky, Theodore S.

“…The interaction between IgE and its receptor FcεRI underlies many allergic responses; here the structure and mechanism of a newly engineered DARPin inhibitor…”
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Discovery of Protein Phosphatase Inhibitor Classes by Biology-Oriented Synthesis by Nören-Müller, Andrea, Reis-Corrêa, Ivan, Prinz, Heino, Rosenbaum, Claudia, Saxena, Krishna, Schwalbe, Harald J., Vestweber, Dietmar, Cagna, Guiseppe, Schunk, Stefan, Schwarz, Oliver, Schiewe, Hajo, Waldmann, Herbert

“…Protein phosphatases have very recently emerged as important targets for chemical biology and medicinal chemistry research, and new phosphatase inhibitor…”
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Microarray Strategy for Mapping the Substrate Specificity of Protein Tyrosine Phosphatase by Köhn, Maja, Gutierrez-Rodriguez, Marta, Jonkheijm, Pascal, Wetzel, Stefan, Wacker, Ron, Schroeder, Hendrik, Prinz, Heino, Niemeyer, Christof M, Breinbauer, Rolf, Szedlacsek, Stefan E, Waldmann, Herbert

“…Which substrate will it be? Phosphotyrosine peptide microarrays have allowed the substrate specificity to be mapped for two prototypical protein‐tyrosine…”
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Hill coefficients, dose-response curves and allosteric mechanisms by Prinz, Heino

“…Hill coefficients (n H) derived from four parameter logistic fits to dose-response curves were compared to calculated realistic reaction schemes and related to…”
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Drosophila photoreceptors express cysteine peptidase tan by Wagner, Stefanie, Heseding, Christiane, Szlachta, Kamila, True, John R., Prinz, Heino, Hovemann, Bernhard T.

“…The Drosophila mutant tan (t) shows reciprocal pigmentation defects compared with the ebony (e) mutant. Visual phenotypes, however, are similar in both flies:…”
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Synthesis and evaluation of the antitumor agent TMC-69-6H and a focused library of analogs by Fürstner, Alois, Feyen, Fabian, Prinz, Heino, Waldmann, Herbert

“…A concise, efficient and flexible total synthesis of the potent antitumor agent TMC-69-6H ( 2 ) is described. Key steps involve the palladium catalyzed…”
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Novel Genes Coding for Lithotrophic Sulfur Oxidation of Paracoccus pantotrophus GB17 by Friedrich, C G, Quentmeier, A, Bardischewsky, F, Rother, D, Kraft, R, Kostka, S, Prinz, H

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Substrate binding modes and anomer selectivity of chitinase A from Vibrio harveyi by Suginta, Wipa, Pantoom, Supansa, Prinz, Heino

“…High-performance liquid chromatography mass spectrometry (HPLC MS) was employed to assess the binding behaviors of various substrates to Vibrio harveyi…”
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Heterobifunctional crosslinkers for tethering single ligand molecules to scanning probes by Riener, Christian K., Kienberger, Ferry, Hahn, Christoph D., Buchinger, Gerhard M., Egwim, Innocent O.C., Haselgrübler, Thomas, Ebner, Andreas, Romanin, Christoph, Klampfl, Christian, Lackner, Bernd, Prinz, Heino, Blaas, Dieter, Hinterdorfer, Peter, Gruber, Hermann J.

“…Single molecule recognition force microscopy (SMRFM) is a versatile atomic force microscopy (AFM) method to probe specific interactions of cognitive molecules…”
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The Kinetic Mechanism of Ran-Nucleotide Exchange Catalyzed by RCC1 by Klebe, Christian, Prinz, Heino, Wittinghofer, Alfred, Goody, Roger S

“…The interaction of Ran, a Ras-related nuclear GTP-binding protein, with its guanine nucleotide exchange factor RCC1 has been studied by equilibrium and…”
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The Ras Mutant D119N Is Both Dominant Negative and Activated by Cool, Robbert H., Schmidt, Gudula, Lenzen, Christian U., Prinz, Heino, Vogt, Dorothee, Wittinghofer, Alfred

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Simplification traps by Prinz, Heino

“…When experiments are analyzed with simple functions, one gets simple results. A trap springs when experiments show deviations from the expected simplicity…”
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Potent family-18 chitinase inhibitors: x-ray structures, affinities, and binding mechanisms by Pantoom, Supansa, Vetter, Ingrid R, Prinz, Heino, Suginta, Wipa

“…Six novel inhibitors of Vibrio harveyi chitinase A (VhChiA), a family-18 chitinase homolog, were identified by in vitro screening of a library of…”
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3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors by Weide, Timo, Arve, Lars, Prinz, Heino, Waldmann, Herbert, Kessler, Horst

“…The solid-phase supported synthesis and antiphosphatase activity of a series of indolizines are reported. In the course of studies directed toward the…”
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Kinetic Analysis by Fluorescence of the Interaction between Ras and the Catalytic Domain of the Guanine Nucleotide Exchange Factor Cdc25Mm by Lenzen, Christian, Cool, Robbert H, Prinz, Heino, Kuhlmann, Jürgen, Wittinghofer, Alfred

“…Guanine nucleotide exchange factors (GEFs) activate Ras proteins by stimulating the exchange of GTP for GDP in a multistep mechanism which involves binary and…”
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Potent Family-18 Chitinase Inhibitors by Pantoom, Supansa, Vetter, Ingrid R., Prinz, Heino, Suginta, Wipa

“…Six novel inhibitors of Vibrio harveyi chitinase A (VhChiA), a family-18 chitinase homolog, were identified by in vitro screening of a library of…”
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Brunsvicamides A−C:  Sponge-Related Cyanobacterial Peptides with Mycobacterium tuberculosis Protein Tyrosine Phosphatase Inhibitory Activity by Müller, Daniela, Krick, Anja, Kehraus, Stefan, Mehner, Christian, Hart, Mark, Küpper, Frithjof C, Saxena, Krishna, Prinz, Heino, Schwalbe, Harald, Janning, Petra, Waldmann, Herbert, König, Gabriele M

“…The cyanobacterium Tychonema sp. produces the new cyclic hexapeptides brunsvicamide A−C (1−3). Brunsvicamide B (2) and C (3) selectively inhibit the…”
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cAPK-phosphorylation controls the interaction of the regulatory domain of cardiac myosin binding protein C with myosin-S2 in an on-off fashion by Gruen, Mathias, Prinz, Heino, Gautel, Mathias

“…Myosin binding protein C is a protein of the myosin filaments of striated muscle which is expressed in isoforms specific for cardiac and skeletal muscle. The…”
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The Core Structures of Roseophilin and the Prodigiosin Alkaloids Define a New Class of Protein Tyrosine Phosphatase Inhibitors by Fürstner, Alois, Reinecke, Kerstin, Prinz, Heino, Waldmann, Herbert

“…A common core. Protein phosphatases, such as the dual‐specificity phosphatase VHR and the tyrosine phosphatase PTP1B, are key regulators of innumerable…”
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