Search Results - "Prinz, Bianka"

Development and characterization of a novel anti-OX40 antibody for potent immune activation by Kuang, Zhihui, Jing, Hua, Wu, Zhihai, Wang, Jie, Li, Yiming, Ni, Haiqing, Zhang, Pan, Wu, Weiwei, Wu, Min, Zhou, Shuaixiang, Qiu, Xuan, Wu, Dongdong, Prinz, Bianka, Baruah, Hemanta, Chen, Bingliang, Yu, Michael, Liu, Junjian

“…With the great success of anti-CTLA-4 and anti-PD-1 therapeutics in cancer immunotherapy, tumor necrosis factor receptor superfamily members have been…”
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Combined strategies for effective cancer immunotherapy with a novel anti-CD47 monoclonal antibody by Ni, Haiqing, Cao, Lei, Wu, Zhihai, Wang, Li, Zhou, Shuaixiang, Guo, Xiaoli, Gao, Yarong, Jing, Hua, Wu, Min, Liu, Yang, Ding, Jiazheng, Zhang, Pan, Zhou, Ying, Chen, Bingliang, Xiong, Yao, Sun, Jiya, Prinz, Bianka, Baruah, Hemanta, Geoghegan, James, Yu, Michael, Wu, Weiwei, Liu, Junjian

“…CD47 is a widely expressed cell-surface protein that regulates phagocytosis mediated by cells of the innate immune system, such as macrophages and dendritic…”
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Assessment and incorporation of in vitro correlates to pharmacokinetic outcomes in antibody developability workflows by Jain, Tushar, Prinz, Bianka, Marker, Alexander, Michel, Alexander, Reichel, Katrin, Czepczor, Valerie, Klieber, Sylvie, Sun, Wei, Kathuria, Sagar, Oezguer Bruederle, Sevim, Lange, Christian, Wahl, Lena, Starr, Charles, Masiero, Alessandro, Avery, Lindsay

“…In vitro assessments for the prediction of pharmacokinetic (PK) behavior of biotherapeutics can help identify corresponding liabilities significantly earlier…”
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Optimization of a glycoengineered Pichia pastoris cultivation process for commercial antibody production by Ye, Jianxin, Ly, Jeffrey, Watts, Kathryn, Hsu, Amy, Walker, Andre, McLaughlin, Kathleen, Berdichevsky, Marina, Prinz, Bianka, Sean Kersey, D., d'Anjou, Marc, Pollard, David, Potgieter, Thomas

“…Glycoengineering enabled the production of proteins with human N‐linked glycans by Pichia pastoris. This study used a glycoengineered P. pastoris strain which…”
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A dual-mode surface display system for the maturation and production of monoclonal antibodies in glyco-engineered Pichia pastoris by Shaheen, Hussam H, Prinz, Bianka, Chen, Ming-Tang, Pavoor, Tej, Lin, Song, Houston-Cummings, Nga Rewa, Moore, Renee, Stadheim, Terrance A, Zha, Dongxing

“…State-of-the-art monoclonal antibody (mAb) discovery methods that utilize surface display techniques in prokaryotic and eukaryotic cells require multiple steps…”
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Characterization of the Pichia pastoris protein-O-mannosyltransferase gene family by Nett, Juergen H, Cook, W James, Chen, Ming-Tang, Davidson, Robert C, Bobrowicz, Piotr, Kett, Warren, Brevnova, Elena, Potgieter, Thomas I, Mellon, Mark T, Prinz, Bianka, Choi, Byung-Kwon, Zha, Dongxing, Burnina, Irina, Bukowski, John T, Du, Min, Wildt, Stefan, Hamilton, Stephen R

“…The methylotrophic yeast, Pichiapastoris, is an important organism used for the production of therapeutic proteins. However, the presence of fungal-like…”
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High-throughput screening for expression of heterologous proteins in the yeast Pichia pastoris by Boettner, Mewes, Prinz, Bianka, Holz, Caterina, Stahl, Ulf, Lang, Christine

“…The methylotrophic yeast Pichia pastoris has become a powerful host for the heterologous expression of proteins. In order to provide proteins for the ‘protein…”
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High-throughput screening and selection of yeast cell lines expressing monoclonal antibodies by Barnard, Gavin C, Kull, Angela R, Sharkey, Nathan S, Shaikh, Seemab S, Rittenhour, Alissa M, Burnina, Irina, Jiang, Youwei, Li, Fang, Lynaugh, Heather, Mitchell, Teresa, Nett, Juergen H, Nylen, Adam, Potgieter, Thomas I, Prinz, Bianka, Rios, Sandra E, Zha, Dongxing, Sethuraman, Natarajan, Stadheim, Terrance A, Bobrowicz, Piotr

“…The methylotrophic yeast Pichia pastoris has recently been engineered to express therapeutic glycoproteins with uniform human N-glycans at high titers. In…”
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Functional Characterization of the Recombinant N-Methyltransferase Domain from the Multienzyme Enniatin Synthetase by Hornbogen, Till, Riechers, Sean-Patrick, Prinz, Bianka, Schultchen, Jeffrey, Lang, Christine, Schmidt, Sebastian, Mügge, Clemens, Turkanovic, Suada, Süssmuth, Roderich D., Tauberger, Eva, Zocher, Rainer

“…A 51 kDa fusion protein incorporating the N‐methyltransferase domain of the multienzyme enniatin synthetase from Fusarium scirpi was expressed in Saccharomyces…”
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Addressing polyspecificity of antibodies selected from an in vitro yeast presentation system: a FACS-based, high-throughput selection and analytical tool by Xu, Yingda, Roach, William, Sun, Tingwan, Jain, Tushar, Prinz, Bianka, Yu, Ta-Yi, Torrey, Joshua, Thomas, Jerry, Bobrowicz, Piotr, Vásquez, Maximiliano, Wittrup, K. Dane, Krauland, Eric

“…Low expression, poor solubility, and polyspecificity are significant obstacles that have impeded the development of antibodies discovered from in vitro display…”
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Abstract 526: Novel mechanisms of Neuropilin-1 inhibition result in improved tumor growth inhibition in vivo by Sethumadhavan, Shalini, Zhu, Eric, Fulgham, Aaron, Abbassi, Mandana, Apte, Ameya, Liao, Tiffany, Merriman, Chengfeng, Molloy, Katherine, Stein, Caitlin, Hanna, Amber, Geoghegan, James, Prinz, Bianka, Dai, Hongyue, Hurov, Jonathan, Huang, Pearl, Blom, Daniel

“…Abstract Background Cygnal Therapeutics, pioneer in exoneuronal biology, has identified the neuronal protein, Neuropilin-1 (NRP1) as a critical regulator of…”
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Five birds, one stone: neutralization of α-hemolysin and 4 bi-component leukocidins of Staphylococcus aureus with a single human monoclonal antibody by Rouha, Harald, Badarau, Adriana, Visram, Zehra C, Battles, Michael B, Prinz, Bianka, Magyarics, Zoltán, Nagy, Gábor, Mirkina, Irina, Stulik, Lukas, Zerbs, Manuel, Jägerhofer, Michaela, Maierhofer, Barbara, Teubenbacher, Astrid, Dolezilkova, Ivana, Gross, Karin, Banerjee, Srijib, Zauner, Gerhild, Malafa, Stefan, Zmajkovic, Jakub, Maier, Sabine, Mabry, Robert, Krauland, Eric, Wittrup, K Dane, Gerngross, Tillman U, Nagy, Eszter

“…Staphylococcus aureus is a major human pathogen associated with high mortality. The emergence of antibiotic resistance and the inability of antibiotics to…”
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Purification of common light chain IgG-like bispecific antibodies using highly linear pH gradients by Sharkey, Beth, Pudi, Sarat, Wallace Moyer, Ian, Zhong, Lihui, Prinz, Bianka, Baruah, Hemanta, Lynaugh, Heather, Kumar, Sampath, Wittrup, K Dane, Nett, Juergen H

“…Monovalent bispecific antibodies (BsAbs) are projected to have broad clinical applications due to their ability to bind two different targets simultaneously…”
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Abstract 5792: Rapid and efficient generation of panels of T cell engaging (TCE) multispecific antibodies via complementary technologies by Ahonen, Cory, Sharkey, Nathan, Durkin, Melissa, Avery, Andrew, Battles, Michael, Sharkey, Beth, Barlow, Kyle, Sivasubramanian, Arvind, Stein, Caitlin, Lunde, Bradley, Schutz, Kevin, Prinz, Bianka, Pejchal, Rob, Widboom, Paul, Krauland, Eric

“…Abstract A goal of immunotherapy is to induce an anti-tumor response that is potent and specific. However, there is increasing understanding that currently…”
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Optimization of humanized IgGs in glycoengineered Pichia pastoris by Gerngross, Tillman U, Li, Huijuan, Sethuraman, Natarajan, Stadheim, Terrance A, Zha, Dongxing, Prinz, Bianka, Ballew, Nicole, Bobrowicz, Piotr, Choi, Byung-Kwon, Cook, W James, Cukan, Michael, Houston-Cummings, Nga Rewa, Davidson, Robert, Gong, Bing, Hamilton, Stephen R, Hoopes, Jack P, Jiang, Youwei, Kim, Nam, Mansfield, Renee, Nett, Juergen H, Rios, Sandra, Strawbridge, Rendall, Wildt, Stefan

“…As the fastest growing class of therapeutic proteins, monoclonal antibodies (mAbs) represent a major potential drug class. Human antibodies are glycosylated in…”
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Abstract 596: Optimization of lead antibody selection for XMT-1522, a novel, highly potent HER2-targeted antibody-drug conjugate (ADC) by Bodyak, Natasha, Yurkovetskiy, Alex, Gumerov, Dmitry R., Xiao, Dongmei, Thomas, Joshua D. Thomas D., Poling, Laura L., Qin, LiuLiang, Yin, Mao, DeVit, Michael J., Park, Peter U., Lee, Winnie, Prinz, Bianka, Bergstrom, Donald A., Lowinger, Timothy B.

“…Abstract XMT-1522 is an anti-HER2 ADC that incorporates HT-19, a novel, human anti-HER2 antibody optimized for cytotoxic payload delivery. Several parameters…”
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A novel fragment of antigen binding (Fab) surface display platform using glycoengineered Pichia pastoris by Lin, Song, Houston-Cummings, Nga Rewa, Prinz, Bianka, Moore, Renée, Bobrowicz, Beata, Davidson, Robert C., Wildt, Stefan, Stadheim, Terrance A., Zha, Dongxing

“…A fragment of antigen binding (Fab) surface display system was developed using a glycoengineered Pichia pastoris host strain genetically modified to secrete…”
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Binding of DC-SIGN to glycoproteins expressed in glycoengineered Pichia pastoris by Cukan, Michael C., Hopkins, Daniel, Burnina, Irina, Button, Michelle, Giaccone, Erin, Houston-Cummings, Nga Rewa, Jiang, Youwei, Li, Fang, Mallem, Muralidhar, Mitchell, Teresa, Moore, Renée, Nylen, Adam, Prinz, Bianka, Rios, Sandra, Sharkey, Nathan, Zha, Dongxing, Hamilton, Stephen, Li, Huijuan, Stadheim, Terrance A.

“…Previous studies have shown that glycoproteins expressed in wild-type Pichia pastoris bind to Dendritic cell-SIGN (DC-Specific Intercellular adhesion…”
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Erratum to “Binding of DC-SIGN to glycoproteins expressed in glycoengineered Pichia pastoris” [J. Immunol. Methods Volume 386/1–2 (2012) 34–42] by Cukan, Michael C., Hopkins, Daniel, Burnina, Irina, Button, Michelle, Giaccone, Erin, Houston-Cummings, Nga Rewa, Jiang, Youwei, Li, Fang, Mallem, Muralidhar, Mitchell, Teresa, Moore, Renée, Nylen, Adam, Prinz, Bianka, Rios, Sandra, Sharkey, Nathan, Zha, Dongxing, Hamilton, Stephen, Li, Huijuan, Stadheim, Terrance A.

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Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization by Turnbull, Andrew P, Kümmel, Daniel, Prinz, Bianka, Holz, Caterina, Schultchen, Jeffrey, Lang, Christine, Niesen, Frank H, Hofmann, Klaus-Peter, Delbrück, Heinrich, Behlke, Joachim, Müller, Eva-Christina, Jarosch, Ernst, Sommer, Thomas, Heinemann, Udo

“…BET3 is a component of TRAPP, a complex involved in the tethering of transport vesicles to the cis‐Golgi membrane. The crystal structure of human BET3 has been…”
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