Search Results - "Prinsen, Michael"

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs by Henderson, Neil C, Arnold, Thomas D, Katamura, Yoshio, Giacomini, Marilyn M, Rodriguez, Juan D, McCarty, Joseph H, Pellicoro, Antonella, Raschperger, Elisabeth, Betsholtz, Christer, Ruminski, Peter G, Griggs, David W, Prinsen, Michael J, Maher, Jacquelyn J, Iredale, John P, Lacy-Hulbert, Adam, Adams, Ralf H, Sheppard, Dean

“…Dean Sheppard and his colleagues show that genetic or pharmacological inhibition of α v integrin signaling ameliorates fibrosis in several solid organs…”
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Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering by Heitmeier, Monique R, Hresko, Richard C, Edwards, Rachel L, Prinsen, Michael J, Ilagan, Ma Xenia G, Odom John, Audrey R, Hruz, Paul W

“…Although the Plasmodium falciparum hexose transporter PfHT has emerged as a promising target for anti-malarial therapy, previously identified small-molecule…”
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Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells by Karpova, Darja, Rettig, Michael P, Ritchey, Julie, Cancilla, Daniel, Christ, Stephanie, Gehrs, Leah, Chendamarai, Ezhilarasi, Evbuomwan, Moses O, Holt, Matthew, Zhang, Jingzhu, Abou-Ezzi, Grazia, Celik, Hamza, Wiercinska, Eliza, Yang, Wei, Gao, Feng, Eissenberg, Linda G, Heier, Richard F, Arnett, Stacy D, Meyers, Marvin J, Prinsen, Michael J, Griggs, David W, Trumpp, Andreas, Ruminski, Peter G, Morrow, Dwight M, Bonig, Halvard B, Link, Daniel C, DiPersio, John F

“…Mobilized peripheral blood has become the primary source of hematopoietic stem and progenitor cells (HSPCs) for stem cell transplantation, with a five-day…”
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A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation by Gierse, James, Thorarensen, Atli, Beltey, Konstantine, Bradshaw-Pierce, Erica, Cortes-Burgos, Luz, Hall, Troii, Johnston, Amy, Murphy, Michael, Nemirovskiy, Olga, Ogawa, Shinji, Pegg, Lyle, Pelc, Matthew, Prinsen, Michael, Schnute, Mark, Wendling, Jay, Wene, Steve, Weinberg, Robin, Wittwer, Arthur, Zweifel, Ben, Masferrer, Jaime

“…Autotaxin is the enzyme responsible for the production of lysophosphatidic acid (LPA) from lysophosphatidyl choline (LPC), and it is up-regulated in many…”
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Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist by Schnute, Mark E, Wennerstål, Mattias, Alley, Jennifer, Bengtsson, Martin, Blinn, James R, Bolten, Charles W, Braden, Timothy, Bonn, Tomas, Carlsson, Bo, Caspers, Nicole, Chen, Ming, Choi, Chulho, Collis, Leon P, Crouse, Kimberly, Färnegårdh, Mathias, Fennell, Kimberly F, Fish, Susan, Flick, Andrew C, Goos-Nilsson, Annika, Gullberg, Hjalmar, Harris, Peter K, Heasley, Steven E, Hegen, Martin, Hromockyj, Alexander E, Hu, Xiao, Husman, Bolette, Janosik, Tomasz, Jones, Peter, Kaila, Neelu, Kallin, Elisabet, Kauppi, Björn, Kiefer, James R, Knafels, John, Koehler, Konrad, Kruger, Lars, Kurumbail, Ravi G, Kyne, Jr, Robert E, Li, Wei, Löfstedt, Joakim, Long, Scott A, Menard, Carol A, Mente, Scot, Messing, Dean, Meyers, Marvin J, Napierata, Lee, Nöteberg, Daniel, Nuhant, Philippe, Pelc, Matthew J, Prinsen, Michael J, Rhönnstad, Patrik, Backström-Rydin, Eva, Sandberg, Johnny, Sandström, Maria, Shah, Falgun, Sjöberg, Maria, Sundell, Aron, Taylor, Alexandria P, Thorarensen, Atli, Trujillo, John I, Trzupek, John D, Unwalla, Ray, Vajdos, Felix F, Weinberg, Robin A, Wood, David C, Xing, Li, Zamaratski, Edouard, Zapf, Christoph W, Zhao, Yajuan, Wilhelmsson, Anna, Berstein, Gabriel

“…The nuclear hormone receptor retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) is a promising target for the treatment of autoimmune…”
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Pharmacologic inhibition of RGD‐binding integrins ameliorates fibrosis and improves function following kidney injury by Basta, Jeannine, Robbins, Lynn, Stout, Lisa, Prinsen, Michael J., Griggs, David W., Rauchman, Michael

“…Fibrosis is a final common pathway for many causes of progressive chronic kidney disease (CKD). Arginine–glycine–aspartic acid (RGD)‐binding integrins are…”
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Targeting CXCR4, VLA-4, and CXCR2 for hematopoietic stem cell mobilization by Cancilla, Daniel, Rettig, Michael P., Karpova, Darja, Thakellapalli, Haresh, Singh, Megh, Meyers, Marvin J., Ruminski, Peter G., Christ, Stephanie, Chendamarai, Ezhilarasi, Gao, Feng, Gehrs, Leah, Ritchey, Julie K., Prinsen, Michael, DiPersio, John F.

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Evaluation of spiropiperidine hydantoins as a novel class of antimalarial agents by Meyers, Marvin J., Anderson, Elizabeth J., McNitt, Sarah A., Krenning, Thomas M., Singh, Megh, Xu, Jing, Zeng, Wentian, Qin, Limei, Xu, Wanwan, Zhao, Siting, Qin, Li, Eickhoff, Christopher S., Oliva, Jonathan, Campbell, Mary A., Arnett, Stacy D., Prinsen, Michael J., Griggs, David W., Ruminski, Peter G., Goldberg, Daniel E., Ding, Ke, Liu, Xiaorong, Tu, Zhengchao, Tortorella, Micky D., Sverdrup, Francis M., Chen, Xiaoping

“…[Display omitted] Given the rise of parasite resistance to all currently used antimalarial drugs, the identification of novel chemotypes with unique mechanisms…”
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Discovery of 3‑Cyano‑N‑(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)‑1H‑pyrrolo[2,3‑b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist by Schnute, Mark E, Wennerstål, Mattias, Alley, Jennifer, Bengtsson, Martin, Blinn, James R, Bolten, Charles W, Braden, Timothy, Bonn, Tomas, Carlsson, Bo, Caspers, Nicole, Chen, Ming, Choi, Chulho, Collis, Leon P, Crouse, Kimberly, Färnegårdh, Mathias, Fennell, Kimberly F, Fish, Susan, Flick, Andrew C, Goos-Nilsson, Annika, Gullberg, Hjalmar, Harris, Peter K, Heasley, Steven E, Hegen, Martin, Hromockyj, Alexander E, Hu, Xiao, Husman, Bolette, Janosik, Tomasz, Jones, Peter, Kaila, Neelu, Kallin, Elisabet, Kauppi, Björn, Kiefer, James R, Knafels, John, Koehler, Konrad, Kruger, Lars, Kurumbail, Ravi G, Kyne, Robert E, Li, Wei, Löfstedt, Joakim, Long, Scott A, Menard, Carol A, Mente, Scot, Messing, Dean, Meyers, Marvin J, Napierata, Lee, Nöteberg, Daniel, Nuhant, Philippe, Pelc, Matthew J, Prinsen, Michael J, Rhönnstad, Patrik, Backström-Rydin, Eva, Sandberg, Johnny, Sandström, Maria, Shah, Falgun, Sjöberg, Maria, Sundell, Aron, Taylor, Alexandria P, Thorarensen, Atli, Trujillo, John I, Trzupek, John D, Unwalla, Ray, Vajdos, Felix F, Weinberg, Robin A, Wood, David C, Xing, Li, Zamaratski, Edouard, Zapf, Christoph W, Zhao, Yajuan, Wilhelmsson, Anna, Berstein, Gabriel

“…The nuclear hormone receptor retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) is a promising target for the treatment of autoimmune…”
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Inhibitors of Arg-Gly-Asp-Binding Integrins Reduce Development of Pancreatic Fibrosis in Mice by Ulmasov, Barbara, Neuschwander-Tetri, Brent A, Lai, Jinping, Monastyrskiy, Vladimir, Bhat, Trisha, Yates, Matthew P, Oliva, Jonathan, Prinsen, Michael J, Ruminski, Peter G, Griggs, David W

“…Background & Aims Pancreatic stellate cells (PSCs) regulate the development of chronic pancreatitis (CP) and are activated by the cytokine transforming growth…”
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Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea by Griggs, David W, Prinsen, Michael J, Oliva, Jonathan, Campbell, Mary A, Arnett, Stacy D, Tajfirouz, Deena, Ruminski, Peter G, Yu, Ying, Bond, Brian R, Ji, Yuhua, Neckermann, Georg, Choy, Robert K M, de Hostos, Eugenio, Meyers, Marvin J

“…Racecadotril (acetorphan) is a neutral endopeptidase (NEP) inhibitor with known antidiarrheal activity in animals and humans; however, in humans, it suffers…”
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Mo1233 Pharmacologic Evaluation of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea by Griggs, David W, Prinsen, Michael J, Campbell, Mary, Oliva, Jonathan, Ruminski, Peter, Yu, Ying, Bond, Brian R, Ji, Yuhua, Neckermann, Georg, Choy, Robert, de Hostos, Eugenio L, Meyers, Marvin

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Evaluation of Aminohydantoins as a Novel Class of Antimalarial Agents by Meyers, Marvin J, Tortorella, Micky D, Xu, Jing, Qin, Limei, He, Zhengxiang, Lang, Xingfen, Zeng, Wentian, Xu, Wanwan, Qin, Li, Prinsen, Michael J, Sverdrup, Francis M, Eickhoff, Christopher S, Griggs, David W, Oliva, Jonathan, Ruminski, Peter G, Jacobsen, E. Jon, Campbell, Mary A, Wood, David C, Goldberg, Daniel E, Liu, Xiaorong, Lu, Yongzhi, Lu, Xin, Tu, Zhengchao, Lu, Xiaoyun, Ding, Ke, Chen, Xiaoping

“…Given the threat of drug resistance, there is an acute need for new classes of antimalarial agents that act via a unique mechanism of action relative to…”
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Targeting of alpha(v) integrin identifies a core molecular pathway that regulates fibrosis in several organs by Henderson, Neil C., Arnold, Thomas D., Katamura, Yoshio, Giacomini, Marilyn M., Rodriguez, Juan D., McCarty, Joseph H., Pellicoro, Antonella, Raschperger, Elisabeth, Betsholtz, Christer, Ruminski, Peter G., Griggs, David W., Prinsen, Michael J., Maher, Jacquelyn J., Iredale, John P., Lacy-Hulbert, Adam, Adams, Ralf H., Sheppard, Dean

“…Myofibroblasts are the major source of extracellular matrix components that accumulate during tissue fibrosis, and hepatic stellate cells (HSCs) are believed…”
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Assessment of T-Cell Receptor (TCR) Mediated T-Cell Activation in Acute Myeloid Leukemia at Diagnosis Has Implications for Risk Stratification and Response to Immune Checkpoint Inhibitors by Arthur, Nancy BJ, Gruszczynska, Agata, Illagan, Ma Xenia G, Prinsen, Michael, Heath, Sharon E, Burton, Tasha, Donaldson, Victoria, Shirai, Cara Lunn, Duncavage, Eric J., Cashen, Amanda F, Uy, Geoffrey L, Spencer, David H, Sykes, Stephen M, Ley, Timothy J, Ferraro, Francesca

“…Background Relapse in patients with acute myeloid leukemia (AML) has been, in part, attributed to the ability of leukemic blasts to escape immune surveillance…”
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Targeting CXCR4, VLA4, and CXCR2 for Hematopoietic Stem Cell Mobilization by Cancilla, Daniel, Thakellapalli, Haresh, Meyers, Marvin J, Rettig, Michael P., Chendamarai, Ezhilarasi, Christ, Stephanie, Karpova, Darja, Ruminski, Peter G, Ritchey, Julie K., Morrow, Dwight M., Prinsen, Michael, DiPersio, John F.

“…Background: Hematopoietic stem cell (HSC) transplant is an essential treatment for a variety of blood disorders and malignancies. A key step in this procedure…”
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Targeting of [α.sub.v] integrin identifies a core molecular pathway that regulates fibrosis in several organs by Henderson, Neil C, Arnold, Thomas D, Katamura, Yoshio, Giacomini, Marilyn M, Rodriguez, Juan D, McCarty, Joseph H, Pellicoro, Antonella, Raschperger, Elisabeth, Betsholtz, Christer, Ruminski, Peter G, Griggs, David W, Prinsen, Michael J, Maher, Jacquelyn J, Iredale, John P, Lacy-Hulbert, Adam, Adams, Ralf H, Sheppard, Dean

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Targeting of [alpha]v integrin identifies a core molecular pathway that regulates fibrosis in several organs by Henderson, Neil C, Arnold, Thomas D, Katamura, Yoshio, Giacomini, Marilyn M, Rodriguez, Juan D, Mccarty, Joseph H, Pellicoro, Antonella, Raschperger, Elisabeth, Betsholtz, Christer, Ruminski, Peter G, Griggs, David W, Prinsen, Michael J, Maher, Jacquelyn J, Iredale, John P, Lacy-hulbert, Adam, Adams, Ralf H, Sheppard, Dean

“…Myofibroblasts are the major source of extracellular matrix components that accumulate during tissue fibrosis, and hepatic stellate cells (HSCs) are believed…”
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Selective αv integrin depletion identifies a core, targetable molecular pathway that regulates fibrosis across solid organs by Henderson, Neil C, Arnold, Thomas D, Katamura, Yoshio, Giacomini, Marilyn M, Rodriguez, Juan D, McCarty, Joseph H, Pellicoro, Antonella, Raschperger, Elisabeth, Betsholtz, Christer, Ruminski, Peter G, Griggs, David W, Prinsen, Michael J, Maher, Jacquelyn J, Iredale, John P, Lacy-Hulbert, Adam, Adams, Ralf H, Sheppard, Dean

“…Myofibroblasts are the major source of extracellular matrix components that accumulate during tissue fibrosis, and hepatic stellate cells (HSCs) are the major…”
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Inhibitors of Arg-Gly-Asp-Binding Integrins Reduce Development of Pancreatic Fibrosis in MiceSummary by Barbara Ulmasov, Brent A. Neuschwander-Tetri, Jinping Lai, Vladimir Monastyrskiy, Trisha Bhat, Matthew P. Yates, Jonathan Oliva, Michael J. Prinsen, Peter G. Ruminski, David W. Griggs

“…Background & Aims: Pancreatic stellate cells (PSCs) regulate the development of chronic pancreatitis (CP) and are activated by the cytokine transforming growth…”
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