Search Results - "Prins, N."

The psychometric function: the lapse rate revisited by Prins, Nicolaas

“…In their influential paper, Wichmann and Hill (2001) have shown that the threshold and slope estimates of a psychometric function may be severely biased when…”
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Phase 1/2a Intravenous and Subcutaneous Oligomer-Specific Antibody KHK6640 in Mild to Moderate Alzheimer’s Disease by Cantillon, Marc, Andreasen, N., Prins, N.

“…Background KHK6640 is a novel humanized anti-amyloid beta oligomer-specific antibody. Both KHK6640 and the mouse parent antibody E64 have demonstrated high…”
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Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI by DEN HEIJER, T, VERMEER, S. E, VAN DIJK, E. J, PRINS, N. D, KOUDSTAAL, P. J, HOFMAN, A, BRETELER, M. M. B

“…Type 2 diabetes increases the risk not only of vascular dementia but also of Alzheimer's disease. The question remains whether diabetes increases the risk of…”
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Trajectories of cognitive decline in different types of dementia by Smits, L L, van Harten, A C, Pijnenburg, Y A L, Koedam, E L G E, Bouwman, F H, Sistermans, N, Reuling, I E W, Prins, N D, Lemstra, A W, Scheltens, P, van der Flier, W M

“…To investigate trajectories of cognitive decline in patients with different types of dementia compared to controls in a longitudinal study. In 199 patients…”
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C-reactive protein and cerebral small-vessel disease : The Rotterdam scan study by VAN DIJK, E. J, PRINS, N. D, VERMEER, S. E, VROOMAN, H. A, HOFMAN, A, KOUDSTAAL, P. J, BRETELER, M. M. B

“…Inflammatory processes are involved in the development and consequences of atherosclerosis. Whether these processes are also involved in cerebral small-vessel…”
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Association between blood pressure, white matter lesions, and atrophy of the medial temporal lobe by DEN HEIJER, T, LAUNER, L. J, PRINS, N. D, VAN DIJK, E. J, VERMEER, S. E, HOFMAN, A, KOUDSTAAL, P. J, BRETELER, M. M. B

“…Blood pressure level is associated with the risk of clinical Alzheimer disease (AD), yet the underlying mechanisms are unclear. High blood pressure levels may…”
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Homocysteine and cognitive function in the elderly: The Rotterdam Scan Study by PRINS, N. D, DEN HEIJER, T, HOFMAN, A, KOUDSTAAL, P. J, JOLLES, J, CLARKE, R, BRETELER, M. M. B

“…Elevated plasma total homocysteine (tHcy) concentrations are associated with AD and vascular dementia, but the relation with cognitive performance in…”
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Rationale and study design of a randomized, placebo-controlled, double-blind phase 2b trial to evaluate efficacy, safety, and tolerability of an oral glutaminyl cyclase inhibitor varoglutamstat (PQ912) in study participants with MCI and mild AD—VIVIAD by Vijverberg, E. G. B., Axelsen, T. M., Bihlet, A. R., Henriksen, K., Weber, F., Fuchs, K., Harrison, J. E., Kühn-Wache, K., Alexandersen, P., Prins, N. D., Scheltens, Philip

“…Background Varoglutamstat (formerly PQ912) is a small molecule that inhibits the activity of the glutaminyl cyclase to reduce the level of pyroglutamate-A-beta…”
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High occurrence of transportation and logistics occupations among vascular dementia patients: an observational study by van Loenhoud, A C, de Boer, C, Wols, K, Pijnenburg, Y A, Lemstra, A W, Bouwman, F H, Prins, N D, Scheltens, P, Ossenkoppele, R, van der Flier, W M

“…Growing evidence suggests a role of occupation in the emergence and manifestation of dementia. Occupations are often defined by complexity level, although…”
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Measuring progression of cerebral white matter lesions on MRI: Visual rating and volumetrics by PRINS, N. D, VAN STRAATEN, E. C. W, VAN DIJK, E. J, SIMONI, M, VAN SCHIJNDEL, R. A, VROOMAN, H. A, KOUDSTAAL, P. J, SCHELTENS, P, BRETELER, M. M. B, BARKHOF, F

“…To evaluate the concordance of a volumetric method for measuring white matter lesion (WML) change with visual rating scales. The authors selected a stratified…”
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Effects of selenium accumulation on reproductive functions in Brassica juncea and Stanleya pinnata by Prins, Christine N., Hantzis, Laura J., Quinn, Colin F., Pilon-Smits, Elizabeth A. H.

“…Selenium (Se) is an essential micronutrient for many organisms, but is also a toxin and environmental pollutant at elevated levels. Due to its chemical…”
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Grey zone amyloid burden affects memory function: the SCIENCe project by Ebenau, J. L., Verfaillie, S. C. J., van den Bosch, K. A., Timmers, T., Wesselman, L. M. P., van Leeuwenstijn, M., Tuncel, H., Golla, S. V. S., Yaqub, M. M., Windhorst, A. D., Prins, N. D., Barkhof, F., Scheltens, P., van der Flier, W. M., van Berckel, B. N. M.

“…Purpose To determine thresholds for amyloid beta pathology and evaluate associations with longitudinal memory performance with the aim to identify a grey zone…”
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New Spectroscopic Features Radiated from Low-Atomic-Number Z-Pinch Plasmas by Safronova, A. S., Kantsyrev, V. L., Prins, N. S., Panter, K., Childers, R. R., Shlyaptseva, V. V.

“…Since great advances in late 60s, x-ray plasma spectroscopy continues to prove itself as an invaluable resource in studying astrophysical and laboratory…”
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Efficacy of early cognitive–linguistic treatment and communicative treatment in aphasia after stroke: a randomised controlled trial (RATS-2) by de Jong-Hagelstein, M, van de Sandt-Koenderman, W M E, Prins, N D, Dippel, D W J, Koudstaal, P J, Visch-Brink, E G

“…BackgroundThe two main approaches in aphasia treatment are cognitive–linguistic treatment (CLT), aimed at restoring the linguistic levels affected, semantics,…”
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Phase 2A Learnings Incorporated into RewinD-LB, a Phase 2B Clinical Trial of Neflamapimod in Dementia with Lewy Bodies by Prins, N. D., de Haan, W., Gardner, A., Blackburn, K., Chu, H.-M., Galvin, J. E., Alam, John J.

“…Background In an exploratory 91-participant phase 2a clinical trial (AscenD-LB, NCT04001517) in dementia with Lewy bodies (DLB), neflamapimod showed…”
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Neuroanatomical localisation and clinical correlates of white matter lesions in the elderly by Artero, S, Tiemeier, H, Prins, N D, Sabatier, R, Breteler, M M B, Ritchie, K

“…Background: White matter lesions (WML) in elderly people co-occur with hypertension, depression, and cognitive impairment. Little is known about the density…”
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Arterial oxygen saturation, COPD, and cerebral small vessel disease by van Dijk, E J, Vermeer, S E, de Groot, J C, van de Minkelis, J, Prins, N D, Oudkerk, M, Hofman, A, Koudstaal, P J, Breteler, M M B

“…Objective: To study whether lower arterial oxygen saturation (SaO2) and chronic obstructive pulmonary disease (COPD) are associated with cerebral white matter…”
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Disturbed phase relations in white matter hyperintensity based vascular dementia: An EEG directed connectivity study by van Straaten, E.C.W, den Haan, J, de Waal, H, van der Flier, W.M, Barkhof, F, Prins, N.D, Stam, C.J

“…Highlights • Directed functional connectivity shows a phase lead of the frontal regions to parieto-occipital regions in subjects without objective cognitive…”
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MR spectroscopy of brain white matter in the prediction of dementia by DEN HEIJER, T, SIJENS, P. E, PRINS, N. D, HOFMAN, A, KOUDSTAAL, P. J, OUDKERK, M, BRETELER, M. M. B

“…Previous 1H-MR spectroscopy (MRS) studies compared biochemical spectra of persons with dementia with those of healthy control subjects. Given the long…”
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5‐HT4 receptors on cholinergic nerves involved in contractility of canine and human large intestine longitudinal muscle by Prins, N H, Akkermans, L M A, Lefebvre, R A, Schuurkes, J A J

“…5‐HT4 receptors mediate circular muscle relaxation in both human and canine large intestine, but this phenomenon alone can not explain the improvement in…”
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