Search Results - "Prins, Bram P."

Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations by Prins, Bram P., Kuchenbaecker, Karoline B., Bao, Yanchun, Smart, Melissa, Zabaneh, Delilah, Fatemifar, Ghazaleh, Luan, Jian’an, Wareham, Nick J., Scott, Robert A., Perry, John R. B., Langenberg, Claudia, Benzeval, Michaela, Kumari, Meena, Zeggini, Eleftheria

“…Serum biomarker levels are associated with the risk of complex diseases. Here, we aimed to gain insights into the genetic architecture of biomarker traits…”
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Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age by Harris, Sarah E., Cox, Simon R., Bell, Steven, Marioni, Riccardo E., Prins, Bram P., Pattie, Alison, Corley, Janie, Muñoz Maniega, Susana, Valdés Hernández, Maria, Morris, Zoe, John, Sally, Bronson, Paola G., Tucker-Drob, Elliot M., Starr, John M., Bastin, Mark E., Wardlaw, Joanna M., Butterworth, Adam S., Deary, Ian J.

“…Identifying biological correlates of late life cognitive function is important if we are to ascertain biomarkers for, and develop treatments to help reduce,…”
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Genomic atlas of the human plasma proteome by Sun, Benjamin B., Maranville, Joseph C., Peters, James E., Stacey, David, Staley, James R., Blackshaw, James, Burgess, Stephen, Jiang, Tao, Paige, Ellie, Surendran, Praveen, Oliver-Williams, Clare, Kamat, Mihir A., Prins, Bram P., Wilcox, Sheri K., Zimmerman, Erik S., Chi, An, Bansal, Narinder, Spain, Sarah L., Wood, Angela M., Morrell, Nicholas W., Bradley, John R., Janjic, Nebojsa, Roberts, David J., Ouwehand, Willem H., Todd, John A., Soranzo, Nicole, Suhre, Karsten, Paul, Dirk S., Fox, Caroline S., Plenge, Robert M., Danesh, John, Runz, Heiko, Butterworth, Adam S.

“…Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control…”
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Genetics of coronary artery disease: Genome-wide association studies and beyond by Prins, Bram P, Lagou, Vasiliki, Asselbergs, Folkert W, Snieder, Harold, Fu, Jingyuan

“…Abstract Genome-wide association (GWA) studies on coronary artery disease (CAD) have been very successful, identifying a total of 32 susceptibility loci so…”
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Trans‐ethnic genomic informed risk assessment for Alzheimer's disease: An International Hundred K+ Cohorts Consortium study by Sleiman, Patrick M., Qu, Hui‐Qi, Connolly, John J., Mentch, Frank, Pereira, Alexandre, Lotufo, Paulo A., Tollman, Stephen, Choudhury, Ananyo, Ramsay, Michele, Kato, Norihiro, Ozaki, Kouichi, Mitsumori, Risa, Jeon, Jae‐Pil, Hong, Chang Hyung, Son, Sang Joon, Roh, Hyun Woong, Lee, Dong‐gi, Mukadam, Naaheed, Foote, Isabelle F., Marshall, Charles R., Butterworth, Adam, Prins, Bram P., Glessner, Joseph T., Hakonarson, Hakon

“…BACKGROUND As a collaboration model between the International HundredK+ Cohorts Consortium (IHCC) and the Davos Alzheimer's Collaborative (DAC), our aim was to…”
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Eosinophil Count Is a Common Factor for Complex Metabolic and Pulmonary Traits and Diseases: The LifeLines Cohort Study by Amini, Marzyeh, Bashirova, Dinara, Prins, Bram P, Corpeleijn, Eva, Bruinenberg, Marcel, Franke, Lude, Harst, Pim van der, Navis, Gerjan, Wolffenbuttel, Bruce H R, Stolk, Ronald P, Wijmenga, Cisca, Postma, Dirkje S, Koppelman, Gerard H, Boezen, H Marike, Vonk, Judith, Snieder, Harold, Alizadeh, Behrooz Z

“…There is ongoing debate on the association between eosinophil count and diseases, as previous studies were inconsistent. We studied the relationship of…”
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QCGWAS: A flexible R package for automated quality control of genome-wide association results by van der Most, Peter J, Vaez, Ahmad, Prins, Bram P, Munoz, M Loretto, Snieder, Harold, Alizadeh, Behrooz Z, Nolte, Ilja M

“…QCGWAS is an R package that automates the quality control of genome-wide association result files. Its main purpose is to facilitate the quality control of a…”
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lodGWAS: a software package for genome-wide association analysis of biomarkers with a limit of detection by Vaez, Ahmad, van der Most, Peter J, Prins, Bram P, Snieder, Harold, van den Heuvel, Edwin, Alizadeh, Behrooz Z, Nolte, Ilja M

“…Genome-wide association study (GWAS) of a biomarker is complicated when the assay procedure of the biomarker is restricted by a Limit of Detection (LOD). Those…”
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Beyond Genome-Wide Association Studies: New Strategies for Identifying Genetic Determinants of Hypertension by Wang, Xiaoling, Prins, Bram P., Sõber, Siim, Laan, Maris, Snieder, Harold

“…Genetic linkage and association methods have long been the most important tools for gene identification in humans. These approaches can either be…”
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Blood Eosinophil Count and Metabolic, Cardiac and Pulmonary Outcomes: A Mendelian Randomization Study by Amini, Marzyeh, Vonk, Judith M., Abbasi, Ali, Prins, Bram P., Bruinenberg, Marcel, Franke, Lude, van der Harst, Pim, Navis, Gerjan, Koppelman, Gerard H., Wolffenbuttel, Bruce H. R., Boezen, H. Marike, Snieder, Harold, Chasman, Daniel I., Alizadeh, Behrooz Z.

“…Blood eosinophil count is associated with a variety of common complex outcomes in epidemiological observation. The aim of this study was to explore the causal…”
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In Silico Post Genome-Wide Association Studies Analysis of C-Reactive Protein Loci Suggests an Important Role for Interferons by Vaez, Ahmad, Jansen, Rick, Prins, Bram P, Hottenga, Jouke-Jan, de Geus, Eco J C, Boomsma, Dorret I, Penninx, Brenda W J H, Nolte, Ilja M, Snieder, Harold, Alizadeh, Behrooz Z

“…Genome-wide association studies (GWASs) have successfully identified several single nucleotide polymorphisms (SNPs) associated with serum levels of C-reactive…”
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Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19 by Gaziano, Liam, Giambartolomei, Claudia, Pereira, Alexandre C., Gaulton, Anna, Posner, Daniel C., Swanson, Sonja A., Ho, Yuk-Lam, Iyengar, Sudha K., Kosik, Nicole M., Vujkovic, Marijana, Gagnon, David R., Bento, A. Patrícia, Barrio-Hernandez, Inigo, Rönnblom, Lars, Hagberg, Niklas, Lundtoft, Christian, Langenberg, Claudia, Pietzner, Maik, Valentine, Dennis, Gustincich, Stefano, Tartaglia, Gian Gaetano, Allara, Elias, Surendran, Praveen, Burgess, Stephen, Zhao, Jing Hua, Peters, James E., Prins, Bram P., Angelantonio, Emanuele Di, Devineni, Poornima, Shi, Yunling, Lynch, Kristine E., DuVall, Scott L., Garcon, Helene, Thomann, Lauren O., Zhou, Jin J., Gorman, Bryan R., Huffman, Jennifer E., O’Donnell, Christopher J., Tsao, Philip S., Beckham, Jean C., Pyarajan, Saiju, Muralidhar, Sumitra, Huang, Grant D., Ramoni, Rachel, Beltrao, Pedro, Danesh, John, Hung, Adriana M., Chang, Kyong-Mi, Sun, Yan V., Joseph, Jacob, Leach, Andrew R., Edwards, Todd L., Cho, Kelly, Gaziano, J. Michael, Butterworth, Adam S., Casas, Juan P.

“…Drug repurposing provides a rapid approach to meet the urgent need for therapeutics to address COVID-19. To identify therapeutic targets relevant to COVID-19,…”
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Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study by Prins, Bram P, Abbasi, Ali, Wong, Anson, Vaez, Ahmad, Nolte, Ilja, Franceschini, Nora, Stuart, Philip E, Guterriez Achury, Javier, Mistry, Vanisha, Bradfield, Jonathan P, Valdes, Ana M, Bras, Jose, Shatunov, Aleksey, Lu, Chen, Han, Buhm, Raychaudhuri, Soumya, Bevan, Steve, Mayes, Maureen D, Tsoi, Lam C, Evangelou, Evangelos, Nair, Rajan P, Grant, Struan F A, Polychronakos, Constantin, Radstake, Timothy R D, van Heel, David A, Dunstan, Melanie L, Wood, Nicholas W, Al-Chalabi, Ammar, Dehghan, Abbas, Hakonarson, Hakon, Markus, Hugh S, Elder, James T, Knight, Jo, Arking, Dan E, Spector, Timothy D, Koeleman, Bobby P C, van Duijn, Cornelia M, Martin, Javier, Morris, Andrew P, Weersma, Rinse K, Wijmenga, Cisca, Munroe, Patricia B, Perry, John R B, Pouget, Jennie G, Jamshidi, Yalda, Snieder, Harold, Alizadeh, Behrooz Z

“…C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are…”
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Rare variant associations with plasma protein levels in the UK Biobank by Dhindsa, Ryan S., Burren, Oliver S., Sun, Benjamin B., Prins, Bram P., Matelska, Dorota, Wheeler, Eleanor, Mitchell, Jonathan, Oerton, Erin, Hristova, Ventzislava A., Smith, Katherine R., Carss, Keren, Wasilewski, Sebastian, Harper, Andrew R., Paul, Dirk S., Fabre, Margarete A., Runz, Heiko, Viollet, Coralie, Challis, Benjamin, Platt, Adam, Vitsios, Dimitrios, Ashley, Euan A., Whelan, Christopher D., Pangalos, Menelas N., Wang, Quanli, Petrovski, Slavé

“…Integrating human genomics and proteomics can help elucidate disease mechanisms, identify clinical biomarkers and discover drug targets 1 – 4 . Because…”
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Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study by Behr, Elijah R, Savio-Galimberti, Eleonora, Barc, Julien, Holst, Anders G, Petropoulou, Evmorfia, Prins, Bram P, Jabbari, Javad, Torchio, Margherita, Berthet, Myriam, Mizusawa, Yuka, Yang, Tao, Nannenberg, Eline A, Dagradi, Federica, Weeke, Peter, Bastiaenan, Rachel, Ackerman, Michael J, Haunso, Stig, Leenhardt, Antoine, Kääb, Stefan, Probst, Vincent, Redon, Richard, Sharma, Sanjay, Wilde, Arthur, Tfelt-Hansen, Jacob, Schwartz, Peter, Roden, Dan M, Bezzina, Connie R, Olesen, Morten, Darbar, Dawood, Guicheney, Pascale, Crotti, Lia, Jamshidi, Yalda

“…Brugada syndrome (BrS) remains genetically heterogeneous and is associated with slowed cardiac conduction. We aimed to identify genetic variation in BrS cases…”
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Evidence for large-scale gene-by-smoking interaction effects on pulmonary function by Aschard, Hugues, Tobin, Martin D, Hancock, Dana B, Skurnik, David, Sood, Akshay, James, Alan, Vernon Smith, Albert, Manichaikul, Ani W, Campbell, Archie, Prins, Bram P, Hayward, Caroline, Loth, Daan W, Porteous, David J, Strachan, David P, Zeggini, Eleftheria, O'Connor, George T, Brusselle, Guy G, Boezen, H Marike, Schulz, Holger, Deary, Ian J, Hall, Ian P, Rudan, Igor, Kaprio, Jaakko, Wilson, James F, Wilk, Jemma B, Huffman, Jennifer E, Hua Zhao, Jing, de Jong, Kim, Lyytikäinen, Leo-Pekka, Wain, Louise V, Jarvelin, Marjo-Riitta, Kähönen, Mika, Fornage, Myriam, Polasek, Ozren, Cassano, Patricia A, Barr, R Graham, Rawal, Rajesh, Harris, Sarah E, Gharib, Sina A, Enroth, Stefan, Heckbert, Susan R, Lehtimäki, Terho, Gyllensten, Ulf, Jackson, Victoria E, Gudnason, Vilmundur, Tang, Wenbo, Dupuis, Josée, Soler Artigas, María, Joshi, Amit D, London, Stephanie J, Kraft, Peter

“…Smoking is the strongest environmental risk factor for reduced pulmonary function. The genetic component of various pulmonary traits has also been…”
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Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19 by Gaziano, Liam, Giambartolomei, Claudia, Pereira, Alexandre C., Gaulton, Anna, Posner, Daniel C., Swanson, Sonja A., Ho, Yuk-Lam, Iyengar, Sudha K., Kosik, Nicole M., Vujkovic, Marijana, Gagnon, David R., Bento, A. Patrícia, Barrio-Hernandez, Inigo, Rönnblom, Lars, Hagberg, Niklas, Lundtoft, Christian, Langenberg, Claudia, Pietzner, Maik, Valentine, Dennis, Gustincich, Stefano, Tartaglia, Gian Gaetano, Allara, Elias, Surendran, Praveen, Burgess, Stephen, Zhao, Jing Hua, Peters, James E., Prins, Bram P., Angelantonio, Emanuele Di, Devineni, Poornima, Shi, Yunling, Lynch, Kristine E., DuVall, Scott L., Garcon, Helene, Thomann, Lauren O., Zhou, Jin J., Gorman, Bryan R., Huffman, Jennifer E., O’Donnell, Christopher J., Tsao, Philip S., Beckham, Jean C., Pyarajan, Saiju, Muralidhar, Sumitra, Huang, Grant D., Ramoni, Rachel, Beltrao, Pedro, Danesh, John, Hung, Adriana M., Chang, Kyong-Mi, Sun, Yan V., Joseph, Jacob, Leach, Andrew R., Edwards, Todd L., Cho, Kelly, Gaziano, J. Michael, Butterworth, Adam S., Casas, Juan P.

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ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals by Bihlmeyer, Nathan A, Brody, Jennifer A, Smith, Albert Vernon, Warren, Helen R, Lin, Honghuang, Isaacs, Aaron, Liu, Ching-Ti, Marten, Jonathan, Radmanesh, Farid, Hall, Leanne M, Grarup, Niels, Mei, Hao, Müller-Nurasyid, Martina, Huffman, Jennifer E, Verweij, Niek, Guo, Xiuqing, Yao, Jie, Li-Gao, Ruifang, van den Berg, Marten, Weiss, Stefan, Prins, Bram P, van Setten, Jessica, Haessler, Jeffrey, Lyytikäinen, Leo-Pekka, Li, Man, Alonso, Alvaro, Soliman, Elsayed Z, Bis, Joshua C, Austin, Tom, Chen, Yii-Der Ida, Psaty, Bruce M, Harrris, Tamara B, Launer, Lenore J, Padmanabhan, Sandosh, Dominiczak, Anna, Huang, Paul L, Xie, Zhijun, Ellinor, Patrick T, Kors, Jan A, Campbell, Archie, Murray, Alison D, Nelson, Christopher P, Tobin, Martin D, Bork-Jensen, Jette, Hansen, Torben, Pedersen, Oluf, Linneberg, Allan, Sinner, Moritz F, Peters, Annette, Waldenberger, Melanie, Meitinger, Thomas, Perz, Siegfried, Kolcic, Ivana, Rudan, Igor, de Boer, Rudolf A, van der Meer, Peter, Lin, Henry J, Taylor, Kent D, de Mutsert, Renée, Trompet, Stella, Jukema, J Wouter, Maan, Arie C, Stricker, Bruno H C, Rivadeneira, Fernando, Uitterlinden, André, Völker, Uwe, Homuth, Georg, Völzke, Henry, Felix, Stephan B, Mangino, Massimo, Spector, Timothy D, Bots, Michiel L, Perez, Marco, Raitakari, Olli T, Kähönen, Mika, Mononen, Nina, Gudnason, Vilmundur, Munroe, Patricia B, Lubitz, Steven A, van Duijn, Cornelia M, Newton-Cheh, Christopher H, Hayward, Caroline, Rosand, Jonathan, Samani, Nilesh J, Kanters, Jørgen K, Wilson, James G, Kääb, Stefan, Polasek, Ozren, van der Harst, Pim, Heckbert, Susan R, Rotter, Jerome I, Mook-Kanamori, Dennis O, Eijgelsheim, Mark, Dörr, Marcus, Jamshidi, Yalda, Asselbergs, Folkert W, Kooperberg, Charles, Lehtimäki, Terho, Arking, Dan E, Sotoodehnia, Nona

“…QT interval, measured through a standard ECG, captures the time it takes for the cardiac ventricles to depolarize and repolarize. JT interval is the component…”
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Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval by Lin, Honghuang, van Setten, Jessica, Smith, Albert V, Bihlmeyer, Nathan A, Warren, Helen R, Brody, Jennifer A, Radmanesh, Farid, Hall, Leanne, Grarup, Niels, Müller-Nurasyid, Martina, Boutin, Thibaud, Verweij, Niek, Lin, Henry J, Li-Gao, Ruifang, van den Berg, Marten E, Marten, Jonathan, Weiss, Stefan, Prins, Bram P, Haessler, Jeffrey, Lyytikäinen, Leo-Pekka, Mei, Hao, Harris, Tamara B, Launer, Lenore J, Li, Man, Alonso, Alvaro, Soliman, Elsayed Z, Connell, John M, Huang, Paul L, Weng, Lu-Chen, Jameson, Heather S, Hucker, William, Hanley, Alan, Tucker, Nathan R, Chen, Yii-Der Ida, Bis, Joshua C, Rice, Kenneth M, Sitlani, Colleen M, Kors, Jan A, Xie, Zhijun, Wen, Chengping, Magnani, Jared W, Nelson, Christopher P, Kanters, Jørgen K, Sinner, Moritz F, Strauch, Konstantin, Peters, Annette, Waldenberger, Melanie, Meitinger, Thomas, Bork-Jensen, Jette, Pedersen, Oluf, Linneberg, Allan, Rudan, Igor, de Boer, Rudolf A, van der Meer, Peter, Yao, Jie, Guo, Xiuqing, Taylor, Kent D, Sotoodehnia, Nona, Rotter, Jerome I, Mook-Kanamori, Dennis O, Trompet, Stella, Rivadeneira, Fernando, Uitterlinden, André, Eijgelsheim, Mark, Padmanabhan, Sandosh, Smith, Blair H, Völzke, Henry, Felix, Stephan B, Homuth, Georg, Völker, Uwe, Mangino, Massimo, Spector, Timothy D, Bots, Michiel L, Perez, Marco, Kähönen, Mika, Raitakari, Olli T, Gudnason, Vilmundur, Arking, Dan E, Munroe, Patricia B, Psaty, Bruce M, van Duijn, Cornelia M, Benjamin, Emelia J, Rosand, Jonathan, Samani, Nilesh J, Hansen, Torben, Kääb, Stefan, Polasek, Ozren, van der Harst, Pim, Heckbert, Susan R, Jukema, J Wouter, Stricker, Bruno H, Hayward, Caroline, Dörr, Marcus, Jamshidi, Yalda, Asselbergs, Folkert W, Kooperberg, Charles, Lehtimäki, Terho, Wilson, James G, Ellinor, Patrick T, Lubitz, Steven A

“…Electrical conduction from the cardiac sinoatrial node to the ventricles is critical for normal heart function. Genome-wide association studies have identified…”
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The genetic landscape of neuro-related proteins in human plasma by Repetto, Linda, Chen, Jiantao, Yang, Zhijian, Zhai, Ranran, Timmers, Paul R H J, Feng, Xiao, Li, Ting, Yao, Yue, Maslov, Denis, Timoshchuk, Anna, Tu, Fengyu, Twait, Emma L, May-Wilson, Sebastian, Muckian, Marisa D, Prins, Bram P, Png, Grace, Kooperberg, Charles, Johansson, Åsa, Hillary, Robert F, Wheeler, Eleanor, Pan, Lu, He, Yazhou, Klasson, Sofia, Ahmad, Shahzad, Peters, James E, Gilly, Arthur, Karaleftheri, Maria, Tsafantakis, Emmanouil, Haessler, Jeffrey, Gyllensten, Ulf, Harris, Sarah E, Wareham, Nicholas J, Göteson, Andreas, Lagging, Cecilia, Ikram, Mohammad Arfan, van Duijn, Cornelia M, Jern, Christina, Landén, Mikael, Langenberg, Claudia, Deary, Ian J, Marioni, Riccardo E, Enroth, Stefan, Reiner, Alexander P, Dedoussis, George, Zeggini, Eleftheria, Sharapov, Sodbo, Aulchenko, Yurii S, Butterworth, Adam S, Mälarstig, Anders, Wilson, James F, Navarro, Pau, Shen, Xia

“…Understanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioural traits and the disease aetiology…”
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