Search Results - "Principe, R."

Patients deriving long-term benefit from immune checkpoint inhibitors demonstrate conserved patterns of site-specific mutations by Principe, Daniel R.

“…Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy and are now the preferred treatment for several tumor types. Though ICIs have shown…”
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The Current Treatment Paradigm for Pancreatic Ductal Adenocarcinoma and Barriers to Therapeutic Efficacy by Principe, Daniel R, Underwood, Patrick W, Korc, Murray, Trevino, Jose G, Munshi, Hidayatullah G, Rana, Ajay

“…Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, with a median survival time of 10-12 months. Clinically, these poor outcomes are attributed to…”
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Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy by Principe, Daniel R, Narbutis, Matthew, Kumar, Sandeep, Park, Alex, Viswakarma, Navin, Dorman, Matthew J, Kamath, Suneel D, Grippo, Paul J, Fishel, Melissa L, Hwang, Rosa F, Thummuri, Dinesh, Underwood, Patrick W, Munshi, Hidayatullah G, Trevino, Jose G, Rana, Ajay

“…Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related death with a median survival time of 6-12 months. Most patients present with…”
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Regulatory T-Cells as an Emerging Barrier to Immune Checkpoint Inhibition in Lung Cancer by Principe, Daniel R., Chiec, Lauren, Mohindra, Nisha A., Munshi, Hidayatullah G.

“…Immune checkpoint inhibitors (ICIs) have revolutionized the treatment paradigm for lung cancer in recent years. These strategies consist of neutralizing…”
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SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth by Park, Seong-Hoon, Ozden, Ozkan, Liu, Guoxiang, Song, Ha Yong, Zhu, Yueming, Yan, Yufan, Zou, Xianghui, Kang, Hong-Jun, Jiang, Haiyan, Principe, Daniel R, Cha, Yong-Il, Roh, Meejeon, Vassilopoulos, Athanassios, Gius, David

“…Sirtuins participate in sensing nutrient availability and directing metabolic activity to match energy needs with energy production and consumption. However,…”
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HAI-1 is an independent predictor of lung cancer mortality and is required for M1 macrophage polarization by Borowicz, Stanley, Principe, Daniel R, Dorman, Matthew J, McHenry, Austin J, Sondarva, Gautam, Kumar, Sandeep, Ananthanarayanan, Vijayalakshmi, Simms, Patricia E, Hess, Ashley, Rana, Ajay

“…Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Though immune checkpoint inhibitors (ICIs) have revolutionized lung…”
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Development and Qualification of High Current Splices and Electrical Connections for the HL-LHC Magnets by Principe, R., Izquierdo-Bermudez, S., Milanese, A., Prin, H., Sgobba, S., Todesco, E.

“…The continuity of the 18, 13, and 2 kA circuits of the HL-LHC magnets heavily relies on splices and electrical connections, to which it is worth devoting a…”
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Targeting And‐1 to overcome radiation resistance in colorectal cancer by Principe, Daniel R.

“…Colorectal cancer (CRC) is a leading cause of cancer‐related death worldwide. Although overall outcomes have improved in recent decades, metastatic disease is…”
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The difficulty in translating the preclinical success of combined TGFβ and immune checkpoint inhibition to clinical trial by Metropulos, Anastasia E., Munshi, Hidayatullah G., Principe, Daniel R.

“…Immune checkpoint inhibitors (ICIs) have transformed the treatment paradigm for solid tumors. However, even in cancers generally considered ICI-sensitive,…”
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Ets1 mediates sorafenib resistance by regulating mitochondrial ROS pathway in hepatocellular carcinoma by Vishnoi, Kanchan, Ke, Rong, Viswakarma, Navin, Srivastava, Piush, Kumar, Sandeep, Das, Subhasis, Singh, Sunil Kumar, Principe, Daniel R., Rana, Ajay, Rana, Basabi

“…The incidence and mortality of hepatocellular carcinoma (HCC) are on a rise in the Western countries including US, attributed mostly to late detection…”
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Metastatic Thymoma Harboring a Deleterious BRCA2 Mutation Derives Durable Clinical Benefit from Olaparib by Principe, Daniel R., Kamath, Suneel D., Munshi, Hidayatullah G., Mohindra, Nisha A.

“…Thymomas comprise a group of rare epithelial neoplasms of the anterior mediastinum. Whereas localized disease carries a favorable prognosis, the majority of…”
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The Oncopig Cancer Model: An Innovative Large Animal Translational Oncology Platform by Schachtschneider, Kyle M, Schwind, Regina M, Newson, Jordan, Kinachtchouk, Nickolas, Rizko, Mark, Mendoza-Elias, Nasya, Grippo, Paul, Principe, Daniel R, Park, Alex, Overgaard, Nana H, Jungersen, Gregers, Garcia, Kelly D, Maker, Ajay V, Rund, Laurie A, Ozer, Howard, Gaba, Ron C, Schook, Lawrence B

“…Despite an improved understanding of cancer molecular biology, immune landscapes, and advancements in cytotoxic, biologic, and immunologic anti-cancer…”
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Mitogen-Activated Protein Kinase Inhibitors and T-Cell-Dependent Immunotherapy in Cancer by Kumar, Sandeep, Principe, Daniel R, Singh, Sunil Kumar, Viswakarma, Navin, Sondarva, Gautam, Rana, Basabi, Rana, Ajay

“…Mitogen-activated protein kinase (MAPK) signaling networks serve to regulate a wide range of physiologic and cancer-associated cell processes. For instance, a…”
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Loss of SMAD4 Is Associated With Poor Tumor Immunogenicity and Reduced PD-L1 Expression in Pancreatic Cancer by Principe, Daniel R, Underwood, Patrick W, Kumar, Sandeep, Timbers, Kaytlin E, Koch, Regina M, Trevino, Jose G, Munshi, Hidayatullah G, Rana, Ajay

“…Transforming Growth Factor β (TGFβ) is a key mediator of immune evasion in pancreatic ductal adenocarcinoma (PDAC), and the addition of TGFβ inhibitors in…”
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Leukocyte subtyping predicts for treatment failure and poor survival in anal squamous cell carcinoma by Principe, Daniel R, Cataneo, Jose L, Timbers, Kaytlin E, Koch, Regina M, Valyi-Nagy, Klara, Mellgren, Anders, Rana, Ajay, Gantt, Gerald

“…Abstract Background Anal squamous cell carcinoma (SCC) generally carries a favorable prognosis, as most tumors are highly sensitive to standard of care…”
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Loss of Sirt2 increases and prolongs a caerulein-induced pancreatitis permissive phenotype and induces spontaneous oncogenic Kras mutations in mice by Quan, Songhua, Principe, Daniel R., Dean, Angela E., Park, Seong-Hoon, Grippo, Paul J., Gius, David, Horikoshi, Nobuo

“…Mice lacking Sirt2 spontaneously develop tumors in multiple organs, as well as when expressed in combination with oncogenic Kras G12D , leading to pancreatic…”
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Magnetic Properties of Pure Iron for the Upgrade of the LHC Superconducting Dipole and Quadrupole Magnets by Parrella, A., Arpaia, P., Buzio, M., Liccardo, A., Pentella, M., Principe, R., Ramos, P. M.

“…The construction of the superconducting magnets for the High-Luminosity upgrade of the Large Hadron Collider accelerator at Conseil Européen pour la Recherche…”
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Chromium (VI) promotes lung cancer initiation by activating EGF/ALDH1A1 signalling by Metropulos, Anastasia E., Becker, Jeffrey H., Principe, Daniel R.

“…Lung cancer is the leading cause of cancer‐related death worldwide and is strongly associated with tobacco smoke exposure. Although smoking remains the most…”
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Case report: Rapid onset, ischemic-type gastritis after initiating oral iron supplementation by Koch, Regina M, Tchernodrinski, Stefan, Principe, Daniel R

“…Oral iron supplements are commonly administered to patients with chronic iron deficiency anemia. This approach is generally well-tolerated, causing only mild…”
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Mechanical Characterization of Low-Carbon Steels for High-Field Accelerator Magnets: Application to Nb Sn Low- \beta Quadrupole MQXF by Santillana, I. Aviles, Vallone, G., Anderssen, E., Bermudez, S. Izquierdo, Bonnin, S., Crouvizier, M. D., Principe, R., Sgobba, S., Weiss, K. P., Bagrets, N., Huang, C. J., Li, L. F.

“…In the quest for higher field accelerator superconducting magnets, essential parts of their design are the so called yokes, which are traditionally made of low…”
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