Search Results - "Princen, H.M.G."

Affitope-based anti-PCSK9 (proprotein convertase subtilisin/kexin type 9) vaccine (AT04A) reduces atherosclerosis in APOE3Leiden.CETP mice by Galabova, G, Juno, C, van der Hoorn, J.W.A, Pieterman, E.J, Pouwer, M, Landlinger, C, Jukema, J.W, Princen, H.M.G, Staffler, G

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Fenofibrate Reduces Atherogenesis in ApoE3Leiden Mice: Evidence for Multiple Antiatherogenic Effects Besides Lowering Plasma Cholesterol by Kooistra, T, Verschuren, L, de Vries-van der Weij, J, Koenig, W, Toet, K, Princen, H M.G, Kleemann, R

“…OBJECTIVE—To demonstrate, quantify, and mechanistically dissect antiatherosclerotic effects of fenofibrate besides lowering plasma cholesterol per se. METHODS…”
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Alirocumab, monoclonal antibody to PCSK9, dose-dependently decreases atherosclerosis, improves plaque stability and shows additive effects with atorvastatin in apoe3leiden.cetp mice by Van der Hoorn, J.W.A, Kühnast, S, Pieterman, E.J, Van den Hoek, A.M, Sasiela, W.J, Gusarova, V, Peyman, A, Schaefer, H.L, Schwahn, U, Jukema, J.W, Princen, H.M.G

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No Effect of C-Reactive Protein on Early Atherosclerosis Development in Apolipoprotein E3-Leiden/Human C-Reactive Protein Transgenic Mice by Trion, A, de Maat, M P.M, Jukema, J W, van der Laarse, A, Maas, M C, Offerman, E H, Havekes, L M, Szalai, A J, Princen, H M.G, Emeis, J J

“…OBJECTIVE—C-reactive protein (CRP) has been associated with risk of cardiovascular disease. It is not clear whether CRP is causally involved in the development…”
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Atorvastatin attenuates diet-induced non-alcoholic steatohepatitis in ApoE3-Leiden mice by reducing hepatic inflammation by Inia, J.A., Van Den Hoek, A.M., Stokman, G., Pieterman, E.J., Morrison, M.C., Jukema, W.J., Princen, H.M.G.

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Efficacy of a novel PCSK9 inhibitory peptide alone and in combination with an anti-ANGPTL3 monoclonal antibody in a mouse model of atherosclerosis by Rolin, B., Princen, H.M.G., Van Den Hoek, A.M., Rakipovski, G., Lau, J.F., Garibay, P.W., Mogensen, C.K.

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Triple Treatment With Alirocumab And Evinacumab On Top Of Atorvastatin Regresses Lesion Size And Improves Plaque Phenotype In Apoe3leiden.Cetp Mice by Pouwer, M., Pieterman, E.J., Worms, N., Keijzer, N., Jukema, J.W., Gusarova, V., Gromada, J., Princen, H.M.G.

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Lipoprotein oxidation, antioxidants and cardiovascular risk: epidemiologic evidence by van de Vijver, L.P.L., Kardinaal, A.F.M., Grobbee, D.E., Princen, H.M.G., van Poppel, G.

“…This review summarizes the scientific evidence for a possible role of antioxidants in the prevention of coronary heart disease (CHD). Dietary antioxidants…”
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IL-1β inhibition combined with cholesterol-lowering therapies decreases synovial lining thickness and spontaneous cartilage degeneration in a humanized dyslipidemia mouse model by van Gemert, Y., Kruisbergen, N.N.L., Blom, A.B., van den Bosch, M.H.J., van der Kraan, P.M., Pieterman, E.J., Princen, H.M.G., van Lent, P.L.E.M.

“…Both systemic inflammation and dyslipidemia contribute to osteoarthritis (OA) development and have been suggested as a possible link between metabolic disease…”
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Novel high-intensive cholesterol-lowering therapies do not ameliorate knee OA development in humanized dyslipidemic mice by van Gemert, Y., Kozijn, A.E., Pouwer, M.G., Kruisbergen, N.N.L., van den Bosch, M.H.J., Blom, A.B., Pieterman, E.J., Weinans, H., Stoop, R., Princen, H.M.G., van Lent, P.L.E.M.

“…High systemic cholesterol levels have been associated with osteoarthritis (OA) development. Therefore, cholesterol lowering by statins has been suggested as a…”
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Intensive cholesterol-lowering treatment reduces synovial inflammation during early collagenase-induced osteoarthritis, but not pathology at end-stage disease in female dyslipidemic E3L.CETP mice by van Gemert, Y., Blom, A.B., Di Ceglie, I., Walgreen, B., Helsen, M., Sloetjes, A., Vogl, T., Roth, J., Kruisbergen, N.N.L., Pieterman, E.J., Princen, H.M.G., van der Kraan, P.M., van Lent, P.L.E.M., van den Bosch, M.H.J.

“…The association between metabolic syndrome (MetS) and osteoarthritis (OA) development has become increasingly recognized. In this context, the exact role of…”
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Variable cartilage degradation in mice with diet-induced metabolic dysfunction: food for thought by Kozijn, A.E., Gierman, L.M., van der Ham, F., Mulder, P., Morrison, M.C., Kühnast, S., van der Heijden, R.A., Stavro, P.M., van Koppen, A., Pieterman, E.J., van den Hoek, A.M., Kleemann, R., Princen, H.M.G., Mastbergen, S.C., Lafeber, F.P.J.G., Zuurmond, A.-M., Bobeldijk, I., Weinans, H., Stoop, R.

“…Human cohort studies have demonstrated a role for systemic metabolic dysfunction in osteoarthritis (OA) pathogenesis in obese patients. To explore the…”
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The coffee diterpene cafestol decreases bile acid synthesis by down-regulation of cholesterol 7α-hydroxylase in apolipoprotein E3-Leiden mice by Roos, B. de, Post, S.M, Vermeulen, M, Afman, L, Jong, M.C, Dahlmans, V.E.H, Havekes, L.M, Stellaard, F, Katan, M.B, Princen, H.M.G

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The Cholesterol-Raising Factor from Coffee Beans, Cafestol, as an Agonist Ligand for the Farnesoid and Pregnane X Receptors by Ricketts, Marie-Louise, Boekschoten, Mark V, Kreeft, Arja J, Hooiveld, Guido J. E. J, Moen, Corina J. A, Müller, Michael, Frants, Rune R, Kasanmoentalib, Soemini, Post, Sabine M, Princen, Hans M. G, Porter, J. Gordon, Katan, Martijn B, Hofker, Marten H, Moore, David D

“…Cafestol, a diterpene present in unfiltered coffee brews such as Scandinavian boiled, Turkish, and cafetière coffee, is the most potent cholesterol-elevating…”
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Strong decrease of high sensitivity C-reactive protein with high-dose atorvastatin in patients with type 2 diabetes mellitus by van de Ree, M.A, Huisman, M.V, Princen, H.M.G, Meinders, A.E, Kluft, C

“…Objective: Statins are known to reduce CRP concentrations, but whether high doses are more effective is not known. Methods: In a prospective double-blind…”
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CYP7A1 A-278C polymorphism affects the response of plasma lipids after dietary cholesterol or cafestol interventions in humans by Hofman, Maaike K, Weggemans, Rianne M, Zock, Peter L, Schouten, Evert G, Katan, Martijn B, Princen, Hans M G

“…The response of plasma lipids to dietary cholesterol and fat varies among individuals. Variations in genes involved in cholesterol metabolism can be important…”
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Consumption of black and green tea has no effect on inflammation, haemostasis and endothelial markers in smoking healthy individuals by DE MAAT, M. P. M, PIJL, H, KLUFT, C, PRINCEN, H. M. G

“…Objective: Firstly, to study the effect of tea and tea polyphenols on cardiovascular risk indicators of the inflammatory system (IL6, IL1β and TNF-α, CRP), and…”
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Genetic variation in the rate-limiting enzyme in cholesterol catabolism (cholesterol 7alpha-hydroxylase) influences the progression of atherosclerosis and risk of new clinical events by Hofman, Maaike K, Princen, Hans M G, Zwinderman, Aeilko H, Jukema, J Wouter

“…CHD (coronary heart disease) is a complex disorder which is, in part, related to serum cholesterol levels. The rate-limiting enzyme in the catabolism of…”
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Dietary vegetable oil and wood derived plant stanol esters reduce atherosclerotic lesion size and severity in apoE3-Leiden transgenic mice by Volger, O.L, Mensink, R.P, Plat, J, Hornstra, G, Havekes, L.M, Princen, H.M.G

“…The hypolipidemic and anti-atherosclerotic effects of vegetable oil- and wood-based dietary plant stanol esters were compared in female apoE*3-Leiden…”
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Fenofibrate reduces the development of atherosclerosis in ApoE⁎3-Leiden transgenic mice: Evidence for anti-atherogenic effects beyond cholesterol-lowering by van der Weij, A.J., Verschuren, L., Princen, H.M.G., Kooistra, T., Kleemann, R.

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