Search Results - "Prince, Peter J."

Prediction of clinical pharmacokinetics of AMG 181, a human anti‐α4β7 monoclonal antibody for treating inflammatory bowel diseases by Li, Hong, Köck, Kathleen, Wisler, John A., Rees, William A., Prince, Peter J., Reynhardt, Kai O., Hsu, Hailing, Yu, Zhigang, Borie, Dominic C., Salinger, David H., Pan, Wei‐Jian

“…The purpose of this study was to predict a safe starting dose of AMG 181, a human anti‐α4β7 antibody for treating inflammatory bowel diseases, based on…”
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Clinical pharmacology of AMG 181, a gut‐specific human anti‐α4β7 monoclonal antibody, for treating inflammatory bowel diseases by Pan, Wei‐Jian, Köck, Kathleen, Rees, William A., Sullivan, Barbara A., Evangelista, Christine M., Yen, Mark, Andrews, Jane M., Radford‐Smith, Graham L., Prince, Peter J., Reynhardt, Kaz O., Doherty, David R., Patel, Sonal K., Krill, Christine D., Zhou, Kefei, Shen, Jing, Smith, Lynn E., Gow, Jason M., Lee, Jonathan, Treacy, Anthony M., Yu, Zhigang, Platt, Virginia M., Borie, Dominic C.

“…Aims AMG 181 pharmacokinetics/pharmacodynamics (PK/PD), safety, tolerability and effects after single subcutaneous (s.c.) or intravenous (i.v.) administration…”
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Off-Target Platelet Activation in Macaques Unique to a Therapeutic Monoclonal Antibody by Santostefano, Michael J., Kirchner, Jacqueline, Vissinga, Christine, Fort, Madeline, Lear, Sean, Pan, Wei-Jian, Prince, Peter J., Hensley, Kelly M., Tran, Duc, Rock, Dan, Vargas, Hugo M., Narayanan, Padma, Jawando, Remi, Rees, William, Reindel, James F., Reynhardt, Kai, Everds, Nancy

“…AMG X, a human neutralizing monoclonal antibody (mAb) against a soluble human protein, caused thrombocytopenia, platelet activation, reduced mean arterial…”
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Measurement of in vivo therapeutic mAb concentrations: comparison of conventional serum/plasma collection and analysis to dried blood spot sampling by Matsuda, Katherine C, Hall, Colin, Baker-Lee, Cassandra, Soto, Marcus, Scott, George, Prince, Peter J, Retter, Marc W

“…Development of an alternative sampling method that uses small amounts of whole blood, such as dried blood spots (DBS), would be an advance in the quantitative…”
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Sa1206 Multiple-Dose Pharmacokinetics (PK), Pharmacodynamics (PD), and Safety of AMG 181, a Human Anti-a4β7 Antibody for Treating Inflammatory Bowel Diseases (IBD) by Pan, Wei-Jian, Sullivan, Barbara A, Rees, William A, Evangelista, Christine M, Doherty, David R, Prince, Peter J, Reynhardt, Kai O, Zhou, Kefei, Yen, Mark, Hooper, Michele M, Lee, Jonathan, Yu, Zhigang, Hsu, Hailing, Borie, Dominique C

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Sa1207 Pharmacokinetics/Pharmacodynamics (PK/PD), Efficacy, and Safety of AMG 181 in Subjects With Active, Mild to Moderate Ulcerative Colitis - An Initial Assessment by Pan, Wei-Jian, Radford-Smith, Graham, Andrews, Jane M, Schwartz, Howard I, Sullivan, Barbara A, Evangelista, Christine M, Rees, William A, Doherty, David R, Prince, Peter J, Reynhardt, Kai O, Zhou, Kefei, Johnson, Justo Sierra, Treacy, Anthony M, Lee, Jonathan, Yu, Zhigang, Borie, Dominique C

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Assessment of DBS technology for the detection of therapeutic antibodies by Prince, Peter J, Matsuda, Katherine C, Retter, Mw, Scott, G

“…Quantitating levels of therapeutic proteins in serum or plasma is critical for determining exposure levels and establishing pharmacokinetic parameters…”
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Su2082 Pharmacokinetics (PK), Pharmacodynamics (PD), and Safety of Amg 181, a Fully Human Anti-α4β7 Antibody for Treating Inflammatory Bowel Diseases (IBD) by Pan, Wei-Jian, Sullivan, Barbara A, Evangelista, Christine M, Doherty, David R, Tam, Chi-Yan J, Patel, Sonal K, Prince, Peter J, Reynhardt, Kai O, Rees, William A, Hsu, Hailing, Zhou, Kefei, Gu, Wen, Yen, Mark, Haller, Christine A, Dodson, Susanna, Yu, Zhigang, Wienkers, Larry C, Borie, Dominique C

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Prediction of clinical pharmacokinetics of AMG 181, a human anti-α 4 β 7 monoclonal antibody for treating inflammatory bowel diseases by Li, Hong, Köck, Kathleen, Wisler, John A, Rees, William A, Prince, Peter J, Reynhardt, Kai O, Hsu, Hailing, Yu, Zhigang, Borie, Dominic C, Salinger, David H, Pan, Wei-Jian

“…The purpose of this study was to predict a safe starting dose of AMG 181, a human anti-α 4 β 7 antibody for treating inflammatory bowel diseases, based on…”
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Clinical pharmacology of AMG 181, a gut‐specific human anti‐α 4 β 7 monoclonal antibody, for treating inflammatory bowel diseases by Pan, Wei‐Jian, Köck, Kathleen, Rees, William A., Sullivan, Barbara A., Evangelista, Christine M., Yen, Mark, Andrews, Jane M., Radford‐Smith, Graham L., Prince, Peter J., Reynhardt, Kaz O., Doherty, David R., Patel, Sonal K., Krill, Christine D., Zhou, Kefei, Shen, Jing, Smith, Lynn E., Gow, Jason M., Lee, Jonathan, Treacy, Anthony M., Yu, Zhigang, Platt, Virginia M., Borie, Dominic C.

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