Search Results - "Prim, B."

Age reprogramming: cell rejuvenation by partial reprogramming by Singh, Prim B, Zhakupova, Assem

“…'Age reprogramming' refers to the process by which the molecular and cellular pathways of a cell that are subject to age-related decline are rejuvenated…”
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Epigenome rejuvenation: HP1β mobility as a measure of pluripotent and senescent chromatin ground states by Manukyan, Maria, Singh, Prim B.

“…We measured the dynamics of an essential epigenetic modifier, HP1β, in human cells at different stages of differentiation using Fluorescence Recovery After…”
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HP1 recruits activity-dependent neuroprotective protein to H3K9me3 marked pericentromeric heterochromatin for silencing of major satellite repeats by Mosch, Kerstin, Franz, Henriette, Soeroes, Szabolcs, Singh, Prim B, Fischle, Wolfgang

“…H3 lysine 9 trimethylation (H3K9me3) is a histone posttranslational modification (PTM) that has emerged as hallmark of pericentromeric heterochromatin. This…”
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Age reprogramming and epigenetic rejuvenation by Singh, Prim B, Newman, Andrew G

“…Age reprogramming represents a novel method for generating patient-specific tissues for transplantation. It bypasses the de-differentiation/redifferentiation…”
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Maternal regulation of chromosomal imprinting in animals by Singh, Prim B., Shloma, Victor V., Belyakin, Stepan N.

“…Chromosomal imprinting requires an epigenetic system that “imprints” one of the two parental chromosomes such that it results in a heritable (cell-to-cell)…”
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Mammalian HP1 Isoforms Have Specific Roles in Heterochromatin Structure and Organization by Bosch-Presegué, Laia, Raurell-Vila, Helena, Thackray, Joshua K., González, Jessica, Casal, Carmen, Kane-Goldsmith, Noriko, Vizoso, Miguel, Brown, Jeremy P., Gómez, Antonio, Ausió, Juan, Zimmermann, Timo, Esteller, Manel, Schotta, Gunnar, Singh, Prim B., Serrano, Lourdes, Vaquero, Alejandro

“…HP1 is a structural component of heterochromatin. Mammalian HP1 isoforms HP1α, HP1β, and HP1γ play different roles in genome stability, but their precise role…”
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Heterochromatin and the molecular mechanisms of ‘parent-of-origin’ effects in animals by Singh, Prim B

“…Twenty five years ago it was proposed that conserved components of constitutive heterochromatin assemble heterochromatin-like complexes in euchromatin and this…”
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On the relations of phase separation and Hi-C maps to epigenetics by Singh, Prim B, Newman, Andrew G

“…The relationship between compartmentalization of the genome and epigenetics is long and hoary. In 1928, Heitz defined heterochromatin as the largest…”
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Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells by Maksakova, Irina A, Thompson, Peter J, Goyal, Preeti, Jones, Steven Jm, Singh, Prim B, Karimi, Mohammad M, Lorincz, Matthew C

“…In mouse embryonic stem cells (mESCs), transcriptional silencing of numerous class I and II endogenous retroviruses (ERVs), including IAP, ETn and MMERVK10C,…”
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Pericentric Heterochromatin Generated by HP1 Protein Interaction-defective Histone Methyltransferase Suv39h1 by Muramatsu, Daisuke, Singh, Prim B., Kimura, Hiroshi, Tachibana, Makoto, Shinkai, Yoichi

“…Pericentric regions form epigenetically organized silent heterochromatin structures that accumulate histone H3 lysine 9 trimethylation (H3K9me3) and HP1. At…”
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Maintenance of Stable Heterochromatin Domains by Dynamic HP1 Binding by Cheutin, Thierry, McNairn, Adrian J., Jenuwein, Thomas, Gilbert, David M., Singh, Prim B., Misteli, Tom

“…One function of heterochromatin is the epigenetic silencing by sequestration of genes into transcriptionally repressed nuclear neighborhoods. Heterochromatin…”
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Epigenetic rejuvenation by Manukyan, Maria, Singh, Prim B.

“…Induced pluripotent stem (iPS) cells have provided a rational means of obtaining histo‐compatible tissues for ‘patient‐specific’ regenerative therapies (Hanna…”
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Activity‐DEPendent Transposition by Newman, Andrew G, Bessa, Paraskevi, Tarabykin, Victor, Singh, Prim B

“…Graphical Abstract The authors propose a novel mechanism, termed Activity‐DEPendent Transpositon (ADEPT), in which epigenetic drift and the preferential use of…”
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H3K9 and H4K20 methyltransferases are directly involved in the heterochromatinization of the paternal chromosomes in male Planococcus citri embryos by Osipov, Yakov A., Posukh, Olga V., Kalashnikova, Darya A., Antoshina, Polina A., Laktionov, Petr P., Skrypnik, Polina A., Belyakin, Stepan N., Singh, Prim B.

“…Using a new method for bulk preparation of early stage embryos, we have investigated the role played by putative Planococcus citri H3K9 and H4K20 histone…”
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Deconstructing age reprogramming by Singh, Prim B, Laktionov, Petr P, Newman, Andrew G

“…It has been proposed that age reprogramming enables old cells to be rejuvenated without passage through an embryonic stage (Singh and Zacouto in J Biosci…”
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Biology and Physics of Heterochromatin- Like Domains/Complexes by Singh, Prim B, Belyakin, Stepan N, Laktionov, Petr P

“…The hallmarks of constitutive heterochromatin, HP1 and H3K9me2/3, assemble heterochromatin- domains/complexes outside canonical constitutively heterochromatic…”
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Intrabody-mediated diverting of HP1β to the cytoplasm induces co-aggregation of H3–H4 histones and lamin-B receptor by Cardinale, Alessio, Filesi, Ilaria, Singh, Prim B., Biocca, Silvia

“…Diverting a protein from its intracellular location is a unique property of intrabodies. To interfere with the intracellular traffic of heterochromatin protein…”
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HP1-Driven Micro-Phase Separation of Heterochromatin-Like Domains/Complexes by Singh, Prim B., Newman, Andrew G.

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Pericentric heterochromatin generated by HP1 protein interaction-defective histone methyltransferase Suv39h1 by Muramatsu, Daisuke, Singh, Prim B., Kimura, Hiroshi, Tachibana, Makoto, Shinkai, Yoichi

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Targeting Cbx3 /HP1γ Induces LEF-1 and IL-21R to Promote Tumor-Infiltrating CD8 T-Cell Persistence by Le, Phuong T, Ha, Ngoc, Tran, Ngan K, Newman, Andrew G, Esselen, Katharine M, Dalrymple, John L, Schmelz, Eva M, Bhandoola, Avinash, Xue, Hai-Hui, Singh, Prim B, Thai, To-Ha

“…Immune checkpoint blockade (ICB) relieves CD8 T-cell exhaustion in most mutated tumors, and TCF-1 is implicated in converting progenitor exhausted cells to…”
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