Acute responses of stevia and d-tagatose intake on metabolic parameters and appetite/satiety in insulin resistance

Acute responses of stevia and d-tagatose intake on metabolic parameters and appetite/satiety in insulin resistance

To examine the effects of d-tagatose or stevia preloads on carbohydrate metabolism markers after an oral glucose load, as well as subjective and objective appetite in women with insulin resistance (IR). Randomized controlled crossover study. Women with IR without T2DM (n = 33; aged 23.4 ± 3.8; BMI 2...

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Bibliographic Details
Published in:Clinical nutrition ESPEN Vol. 49; pp. 217 - 224
Main Authors: Sambra, Verónica, Vicuña, Isabella A., Priken, Kathleen M., Luna, Selva L., Allendes, Daniela A., Godoy, Paula M., Novik, Victoria, Vega, Claudia A.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-06-2022
Subjects:
Appetite
Blood Glucose - metabolism
C-Peptide
Cross-Over Studies
d-tagatose
Female
Glucose
Glycemia
Hexoses
Humans
Insulin
Insulin Resistance
Satiety
Stevia
Water - pharmacology
Appetite
IR
VAS
d-tagatose
HOMA-IR
NNS
C-peptide
iAUC
Satiety
Insulin resistance
Stevia
Glycemia
BMI
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Summary:To examine the effects of d-tagatose or stevia preloads on carbohydrate metabolism markers after an oral glucose load, as well as subjective and objective appetite in women with insulin resistance (IR). Randomized controlled crossover study. Women with IR without T2DM (n = 33; aged 23.4 ± 3.8; BMI 28.1 ± 3.4 kg × m−2) underwent three oral glucose loads (3 h each) on three different days. Ten min before oral glucose load, volunteers consumed a preload of 60 mL water (control), 60 mL water with stevia (15.3 mg), or d-tagatose (5000 mg). Serum glucose and C-peptide were evaluated at −10, 30-, 60-, 90-, 120-, and 180-min. Subjective appetite was determined with a visual analog scale. Food intake was measured at ad libitum buffet after 180 min. C-peptide iAUC was significantly higher for stevia (median (IQR): 1033 (711–1293) ng × min × L−1) vs. d-tagatose (794 (366–1134) ng × min × L−1; P = 0.001) or control (730 (516–1078) ng × min × L−1; P = 0.012). At 30- and 60-min serum glucose was higher for stevia vs other conditions (P < 0.01). Volunteers reported greater satiety for stevia and d-tagatose vs. control at 60 min and greater desire to eat for stevia vs. control at 120- min (all P < 0.05). Objective appetite did not vary by condition (P = 0.06). Our findings suggest that these NNS are not inert. Stevia intake produced an acute response on C-peptide release while increased serum glucose at earlier times. It is possible that NNS affects subjective but not objective appetite. This trial is registered at clinicaltrials.gov as NCT04327245. NCT04327245.
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ISSN:2405-4577
2405-4577
DOI:10.1016/j.clnesp.2022.04.018