Correlation between elevated neutrophil lymphocyte ratio, vasotropic inotropic score, cumulative fluid balance and level of reactive oxygen species in septic patients

Introduction . Reactive oxygen species (ROS) serve as a biomarker in sepsis, while neutrophil lymphocyte ratio (NLR), vasotropic inotropic score (VIS), and cumulative fluid balance (CFB) correlate with inflammation and mortality. Understanding the correlation between elevated ROS levels and these ma...

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Bibliographic Details
Published in:	Vestnik anesteziologii i reanimatologii Vol. 21; no. 4; pp. 60 - 68
Main Authors:	Purwoko, P., Dewi, F. H., Prihandana, P. A.
Format:	Journal Article
Language:	English Russian
Published:	New Terra Publishing House 26-08-2024
Subjects:	cfb cumulative fluid balance neutrophil lymphocyte ratio nlr reactive oxygen species ros sepsis septic shock vasotropic inotropic score vis
Online Access:	Get full text
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Summary:	Introduction . Reactive oxygen species (ROS) serve as a biomarker in sepsis, while neutrophil lymphocyte ratio (NLR), vasotropic inotropic score (VIS), and cumulative fluid balance (CFB) correlate with inflammation and mortality. Understanding the correlation between elevated ROS levels and these markers aids in prognostication. The objective is to study the correlation between the increased level of neutrophil/lymphocyte ratio, vasotropic and inotropic index, total fluid balance and reactive oxygen species level in patients with sepsis. Materials and methods. A prospective cohort study in RSUD Dr. Moewardi’s ICU/HCU from June to August 2023 employed univariate, bivariate (Spearman correlation), and multivariate logistic regression analyses. Results . Among 34 sepsis patients, NLR and VIS showed significant positive correlations on day one, and NLR, VIS, and FB on day three. Delta changes in NLR and VIS significantly correlated with ROS. Conclusion . NLR and VIS changes predict ROS levels, while CFB exhibits weak correlations, which deserve additional investigation. This underscores the importance of NLR and VIS as prognostic indicators in sepsis.
ISSN:	2078-5658 2541-8653
DOI:	10.24884/2078-5658-2024-21-4-60-68