Search Results - "Pries, Verena"

Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack by Ziegler, Slava, Pries, Verena, Hedberg, Christian, Waldmann, Herbert

“…Identification and confirmation of bioactive small‐molecule targets is a crucial, often decisive step both in academic and pharmaceutical research. Through the…”
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Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis by Zhu, Jinsheng, Lau, Kelvin, Puschmann, Robert, Harmel, Robert K, Zhang, Youjun, Pries, Verena, Gaugler, Philipp, Broger, Larissa, Dutta, Amit K, Jessen, Henning J, Schaaf, Gabriel, Fernie, Alisdair R, Hothorn, Ludwig A, Fiedler, Dorothea, Hothorn, Michael

“…Many eukaryotic proteins regulating phosphate (Pi) homeostasis contain SPX domains that are receptors for inositol pyrophosphates (PP-InsP), suggesting that…”
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Natural product–inspired cascade synthesis yields modulators of centrosome integrity by Dückert, Heiko, Pries, Verena, Khedkar, Vivek, Menninger, Sascha, Bruss, Hanna, Bird, Alexander W, Maliga, Zoltan, Brockmeyer, Andreas, Janning, Petra, Hyman, Anthony, Grimme, Stefan, Schürmann, Markus, Preut, Hans, Hübel, Katja, Ziegler, Slava, Kumar, Kamal, Waldmann, Herbert

“…Natural product–inspired compounds are primed to interact with and manipulate biological processes, but obtaining these complex molecules poses synthetic…”
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High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines by Filipuzzi, Ireos, Cotesta, Simona, Perruccio, Francesca, Knapp, Britta, Fu, Yue, Studer, Christian, Pries, Verena, Riedl, Ralph, Helliwell, Stephen B, Petrovic, Katarina T, Movva, N Rao, Sanglard, Dominique, Tao, Jianshi, Hoepfner, Dominic

“…Invasive infections by fungal pathogens cause more deaths than malaria worldwide. We found the ergoline compound NGx04 in an antifungal screen, with…”
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Identifizierung der Zielproteine bioaktiver Verbindungen: Die Suche nach der Nadel im Heuhaufen by Ziegler, Slava, Pries, Verena, Hedberg, Christian, Waldmann, Herbert

“…Die Identifizierung und Validierung von Zielmolekülen biologisch aktiver niedermolekularer Verbindungen ist ein äußerst wichtiger, oft maßgebender Schritt in…”
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Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties by Pries, Verena, Nöcker, Christina, Khan, Danish, Johnen, Philipp, Hong, Zebin, Tripathi, Ashutosh, Keller, Anna-Lena, Fitz, Michael, Perruccio, Francesca, Filipuzzi, Ireos, Thavam, Sasikala, Aust, Thomas, Riedl, Ralph, Ziegler, Slava, Bono, Fulvia, Schaaf, Gabriel, Bankaitis, Vytas A, Waldmann, Herbert, Hoepfner, Dominic

“…Invasive fungal infections are accompanied by high mortality rates that range up to 90%. At present, only three different compound classes are available for…”
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Direct Interaction of Chivosazole F with Actin Elicits Cell Responses Similar to Latrunculin A but Distinct from Chondramide by Filipuzzi, Ireos, Thomas, Jason Ray, Pries, Verena, Estoppey, David, Salcius, Michael, Studer, Christian, Schirle, Markus, Hoepfner, Dominic

“…The microbial metabolite Chivosazole F has been described to affect the cytoskeleton and to inhibit actin polymerization in vitro. Applying orthogonal genomic…”
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Advantages and Challenges of Phenotypic Screens: The Identification of Two Novel Antifungal Geranylgeranyltransferase I Inhibitors by Pries, Verena, Cotesta, Simona, Riedl, Ralph, Aust, Thomas, Schuierer, Sven, Tao, Jianshi, Filipuzzi, Ireos, Hoepfner, Dominic

“…Phenotypic screens are effective starting points to identify compounds with desirable activities. To find novel antifungals, we conducted a phenotypic screen…”
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Identifizierung der Zielproteine bioaktiver Verbindungen: Die Suche nach der Nadel im Heuhaufen by Ziegler, Slava, Pries, Verena, Hedberg, Christian, Waldmann, Herbert

“…Die Identifizierung und Validierung von Zielmolekülen biologisch aktiver niedermolekularer Verbindungen ist ein äußerst wichtiger, oft maßgebender Schritt in…”
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