Search Results - "Prier, Christopher K"

Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts by Prier, Christopher K, Arnold, Frances H

“…Despite the astonishing breadth of enzymes in nature, no enzymes are known for many of the valuable catalytic transformations discovered by chemists. Recent…”
Get full text

Enantioselective Aminohydroxylation of Styrenyl Olefins Catalyzed by an Engineered Hemoprotein by Cho, Inha, Prier, Christopher K., Jia, Zhi‐Jun, Zhang, Ruijie K., Görbe, Tamás, Arnold, Frances H.

“…Chiral 1,2‐amino alcohols are widely represented in biologically active compounds from neurotransmitters to antivirals. While many synthetic methods have been…”
Get full text

Stereoselective Enzymatic Synthesis of Heteroatom-Substituted Cyclopropanes by Brandenberg, Oliver F, Prier, Christopher K, Chen, Kai, Knight, Anders M, Wu, Zachary, Arnold, Frances H

“…The repurposing of hemoproteins for non-natural carbene transfer activities has generated enzymes for functions previously accessible only to chemical…”
Get full text

Asymmetric Enzymatic Synthesis of Allylic Amines: A Sigmatropic Rearrangement Strategy by Prier, Christopher K., Hyster, Todd K., Farwell, Christopher C., Huang, Audrey, Arnold, Frances H.

“…Sigmatropic rearrangements, while rare in biology, offer opportunities for the efficient and selective synthesis of complex chemical motifs. A “P411”…”
Get full text

Recent preparative applications of redox enzymes by Prier, Christopher K, Kosjek, Birgit

“…Redox enzymes offer many powerful transformations for the efficient industrial-scale synthesis of diverse chemicals desired by society. Here we survey recent…”
Get full text

Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis by Prier, Christopher K, Rankic, Danica A, MacMillan, David W. C

“…Prier et al examine visible light photoredox catalysis with transition metal complexes with regard to applications in organic synthesis…”
Get full text

Enantioselective, intermolecular benzylic C–H amination catalysed by an engineered iron-haem enzyme by Prier, Christopher K., Zhang, Ruijie K., Buller, Andrew R., Brinkmann-Chen, Sabine, Arnold, Frances H.

“…C–H bonds are ubiquitous structural units of organic molecules. Although these bonds are generally considered to be chemically inert, the recent emergence of…”
Get full text

Discovery of an α-Amino C-H Arylation Reaction Using the Strategy of Accelerated Serendipity by McNally, Andrew, Prier, Christopher K., MacMillan, David W. C.

“…Serendipity has long been a welcome yet elusive phenomenon in the advancement of chemistry. We sought to exploit serendipity as a means of rapidly identifying…”
Get full text

Amine α-heteroarylation via photoredox catalysis: a homolytic aromatic substitution pathway by Prier, Christopher K, MacMillan, David W C

“…The direct α-heteroarylation of tertiary amines has been accomplished photoredox catalysis to generate valuable benzylic amine pharmacophores. A variety of…”
Get full text

Expanding the scope of the Cu assisted Suzuki–Miyaura reaction by Crowley, Brendan M., Potteiger, Craig M., Deng, James Z., Prier, Christopher K., Paone, Daniel V., Burgey, Christopher S.

“…Recent advances in the development of the copper facilitated Suzuki–Miyaura reaction are described. Improvements include expansion of substrate scope to…”
Get full text

Using enzymes to tame nitrogen-centred radicals for enantioselective hydroamination by Ye, Yuxuan, Cao, Jingzhe, Oblinsky, Daniel G., Verma, Deeptak, Prier, Christopher K., Scholes, Gregory D., Hyster, Todd K.

“…The formation of C–N bonds—of great importance to the pharmaceutical industry—can be facilitated enzymatically using nucleophilic and nitrene transfer…”
Get full text

Enantioselective Aminohydroxylation of Styrenyl Olefins Catalyzed by an Engineered Hemoprotein by Cho, Inha, Prier, Christopher K., Jia, Zhi‐Jun, Zhang, Ruijie K., Görbe, Tamás, Arnold, Frances H.

“…Chiral 1,2‐amino alcohols are widely represented in biologically active compounds from neurotransmitters to antivirals. While many synthetic methods have been…”
Get full text

Stereodivergent Synthesis of 3‐Hydroxyprolines and 3‐Hydroxypipecolic Acids via Ketoreductase‐Catalyzed Dynamic Kinetic Reduction by Prier, Christopher K., Lo, Michael M.‐C., Li, Hongming, Yasuda, Nobuyoshi

“…We report a practical enzymatic approach for the stereoselective synthesis of hydroxylated cyclic amino acids. Using ketoreductases, cyclic ketoesters are…”
Get full text

Facile Ring-Opening of Azabicyclic [3.1.0]- and [4.1.0]Aminocyclopropanes to Afford 3-Piperidinone and 3-Azepinone by Lee, Jisun, Berritt, Simon, Prier, Christopher K, Joullié, Madeleine M

“…Azabicyclic [3.1.0] and [4.1.0] Kulinkovich products underwent a facile reduction/fragmentation to afford a variety of 3-piperidinones and 3-azepinones,…”
Get full text

Asymmetric Enzymatic Synthesis of Allylic Amines: A Sigmatropic Rearrangement Strategy by Prier, Christopher K., Hyster, Todd K., Farwell, Christopher C., Huang, Audrey, Arnold, Frances H.

“…Sigmatropic rearrangements, while rare in biology, offer opportunities for the efficient and selective synthesis of complex chemical motifs. A “P411”…”
Get full text

Enzymes for amino acid synthesis by design by Prier, Christopher K.

“…Creating enzymes with new capabilities is a key goal for synthetic biology and sustainable chemistry. Now, computational approaches have been used to quickly…”
Get full text

Use of a Dynamic Flow Platform To Translate a Batch Immobilized Transaminase Process to a Packed Bed Reactor for the Synthesis of an Intermediate of Nemtabrutinib by Di Maso, Michael J., Kuethe, Jeffrey T., Narsimhan, Karthik, Burris, Matthew, Chung, Cheol K., DiBenedetto, Michael, Forstater, Jacob H., Grosser, Shane T., Kuhl, Nadine, Lévesque, François, Maguire, Anne, Maloney, Kevin M., McMullen, Jonathan P., Prier, Christopher K., Qi, Ji, Rivera, Nelo R., Wang, Zhixun, Wyvratt, Brian M., Zewge, Daniel

“…Herein we describe the translation of an immobilized transaminase process in batch to a packed bed reactor for the synthesis of cyrene amine, an intermediate…”
Get full text

Amine α-heteroarylation via photoredox catalysis: a homolytic aromatic substitution pathwayElectronic supplementary information (ESI) available: Experimental procedures, structural proofs, and spectral data for all new compounds are provided (97 pages) (PDF). See DOI: 10.1039/c4sc02155j by Prier, Christopher K, MacMillan, David W. C

“…The direct α-heteroarylation of tertiary amines has been accomplished via photoredox catalysis to generate valuable benzylic amine pharmacophores. A variety of…”
Get full text

Amination of a Green Solvent via Immobilized Biocatalysis for the Synthesis of Nemtabrutinib by Prier, Christopher K., Camacho Soto, Karla, Forstater, Jacob H., Kuhl, Nadine, Kuethe, Jeffrey T., Cheung-Lee, Wai Ling, Di Maso, Michael J., Eberle, Claire M., Grosser, Shane T., Ho, Hsing-I, Hoyt, Erik, Maguire, Anne, Maloney, Kevin M., Makarewicz, Amanda, McMullen, Jonathan P., Moore, Jeffrey C., Murphy, Grant S., Narsimhan, Karthik, Pan, Weilan, Rivera, Nelo R., Saha-Shah, Anumita, Thaisrivongs, David A., Verma, Deeptak, Wyatt, Adeya, Zewge, Daniel

“…Enzymes are capable of unique and selective transformations that can enable efficient chemical production. While many industrial processes have been developed…”
Get full text

Enantioselective, Intermolecular Benzylic C–H Amination Catalyzed by an Engineered Iron-Heme Enzyme by Prier, Christopher K., Zhang, Ruijie K., Buller, Andrew R., Brinkmann-Chen, Sabine, Arnold, Frances H.

“…C–H bonds are ubiquitous structural units of organic molecules; while these bonds are generally considered to be chemically inert, the recent emergence of…”
Get full text