Search Results - "Priebe, Gregory"
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Genomic and epidemiological evidence of bacterial transmission from probiotic capsule to blood in ICU patients
Published in Nature medicine (01-11-2019)“…Probiotics are routinely administered to hospitalized patients for many potential indications 1 but have been associated with adverse effects that may outweigh…”
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Strategies to prevent ventilator-associated pneumonia, ventilator-associated events, and nonventilator hospital-acquired pneumonia in acute-care hospitals: 2022 Update
Published in Infection control and hospital epidemiology (01-06-2022)“…The purpose of this document is to highlight practical recommendations to assist acute care hospitals to prioritize and implement strategies to prevent…”
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Strategies to Prevent Ventilator-Associated Pneumonia in Acute Care Hospitals: 2014 Update
Published in Infection control and hospital epidemiology (01-08-2014)“…Previously published guidelines are available that provide comprehensive recommendations for detecting and preventing healthcare-associated infections (HAIs)…”
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Optimizing surveillance for pediatric ventilator-associated events—But are they preventable?
Published in Infection control and hospital epidemiology (01-02-2023)“…[...]all 3 definitions of VAE had similar associations with clinical outcomes. A limitation of the study is that it applied these definitions retrospectively…”
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Vaccines for Pseudomonas aeruginosa: a long and winding road
Published in Expert review of vaccines (01-04-2014)“…Despite the recognition of Pseudomonas aeruginosa as an opportunistic pathogen, no vaccine against this bacteria has come to market. This review describes the…”
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Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia
Published in Infection and immunity (01-10-2015)“…Th17 immunity in the gastrointestinal tract is regulated by the intestinal microbiota composition, particularly the presence of segmented filamentous bacteria…”
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Genetic variation of a bacterial pathogen within individuals with cystic fibrosis provides a record of selective pressures
Published in Nature genetics (01-01-2014)“…Roy Kishony and colleagues sequenced the genomes of Burkholderia dolosa isolates from patients with cystic fibrosis, using colony resequencing and deep…”
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Plasma Microbial Cell‐Free DNA Metagenomic Next‐Generation Sequencing in People With Cystic Fibrosis
Published in Pediatric pulmonology (06-11-2024)Get full text
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Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes
Published in Nature genetics (01-12-2011)“…Roy Kishony and colleagues sequenced the genomes of 112 Burkholderia dolosa isolates recovered from 14 individuals with cystic fibrosis as part of a…”
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An Oxygen-Sensing Two-Component System in the Burkholderia cepacia Complex Regulates Biofilm, Intracellular Invasion, and Pathogenicity
Published in PLoS pathogens (01-01-2017)“…Burkholderia dolosa is a member of the Burkholderia cepacia complex (BCC), which is a group of bacteria that cause chronic lung infection in patients with…”
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PLGA-encapsulation of the Pseudomonas aeruginosa PopB vaccine antigen improves Th17 responses and confers protection against experimental acute pneumonia
Published in Vaccine (12-11-2018)“…•Pseudomonas aeruginosa PopB was encapsulated into PLGA nanoparticles.•Vaccination with PopB-PLGA protected against lethal P. aeruginosa challenge.•PopB-PLGA…”
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Inescapable Need for Neutrophils as Mediators of Cellular Innate Immunity to Acute Pseudomonas aeruginosa Pneumonia
Published in Infection and Immunity (01-12-2009)“…Pseudomonas aeruginosa is a leading cause of pneumonia, and many components of the innate immune system have been proposed to exert important effects in…”
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Bundled Care to Reduce Sepsis Mortality: The Improving Pediatric Sepsis Outcomes (IPSO) Collaborative
Published in Pediatrics (Evanston) (01-08-2023)“…We sought to improve utilization of a sepsis care bundle and decrease 3- and 30- day sepsis-attributable mortality, as well as determine which care elements of…”
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Th17-stimulating Protein Vaccines Confer Protection against Pseudomonas aeruginosa Pneumonia
Published in American journal of respiratory and critical care medicine (01-09-2012)“…New vaccine approaches are needed for Pseudomonas aeruginosa, which continues to be a major cause of serious pulmonary infections. Although Th17 cells can…”
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Trehalose biosynthesis promotes Pseudomonas aeruginosa pathogenicity in plants
Published in PLoS pathogens (01-03-2013)“…Pseudomonas aeruginosa strain PA14 is a multi-host pathogen that infects plants, nematodes, insects, and vertebrates. Many PA14 factors are required for…”
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Anesthetics isoflurane and sevoflurane attenuate flagellin-mediated inflammation in the lung
Published in Biochemical and biophysical research communications (11-06-2021)“…Isoflurane and sevoflurane are volatile anesthetics (VA) widely used in clinical practice to provide general anesthesia. We and others have previously shown…”
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Global and local selection acting on the pathogen Stenotrophomonas maltophilia in the human lung
Published in Nature communications (19-01-2017)“…Bacterial populations diversify during infection into distinct subpopulations that coexist within the human body. Yet, it is unknown to what extent…”
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Multicomponent Pseudomonas aeruginosa Vaccines Eliciting Th17 Cells and Functional Antibody Responses Confer Enhanced Protection against Experimental Acute Pneumonia in Mice
Published in Infection and immunity (20-10-2022)“…The Gram-negative pathogen Pseudomonas aeruginosa is a common cause of pneumonia in hospitalized patients. Its increasing antibiotic resistance and widespread…”
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Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections
Published in Nature communications (09-03-2022)“…Acute bacterial infections are often treated empirically, with the choice of antibiotic therapy updated during treatment. The effects of such rapid antibiotic…”
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Incident Stenotrophomonas maltophilia infection and lung function decline in cystic fibrosis
Published in Pediatric pulmonology (01-10-2017)“…Objectives To determine whether incident detection of Stenotrophomonas maltophilia (SM) in patients with cystic fibrosis (CF) is associated with accelerated…”
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