Search Results - "Prideaux, Matthew"

The Osteocyte: An Endocrine Cell … and More by Dallas, Sarah L, Prideaux, Matthew, Bonewald, Lynda F

“…Few investigators think of bone as an endocrine gland, even after the discovery that osteocytes produce circulating fibroblast growth factor 23 that targets…”
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Elevated glucose acts directly on osteocytes to increase sclerostin expression in diabetes by Pacicca, Donna M., Brown, Tammy, Watkins, Dara, Kover, Karen, Yan, Yun, Prideaux, Matthew, Bonewald, Lynda

“…Bone quality in diabetic patients is compromised, leading to weaker bones and increased fracture risk. However, the mechanism by which this occurs in diabetic…”
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Regulation of FGF23 expression in IDG-SW3 osteocytes and human bone by pro-inflammatory stimuli by Ito, Nobuaki, Wijenayaka, Asiri R., Prideaux, Matthew, Kogawa, Masakazu, Ormsby, Renee T., Evdokiou, Andreas, Bonewald, Lynda F., Findlay, David M., Atkins, Gerald J.

“…•Sepsis patients experience transient hypophosphataemia suggesting a role for FGF23.•TNF, TWEAK, IL-1β and LPS increased Fgf23 mRNA levels in osteocytes and…”
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Osteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection by Yoshimoto, Tetsuya, Kittaka, Mizuho, Doan, Andrew Anh Phuong, Urata, Rina, Prideaux, Matthew, Rojas, Roxana E., Harding, Clifford V., Henry Boom, W., Bonewald, Lynda F., Greenfield, Edward M., Ueki, Yasuyoshi

“…The impact of bone cell activation on bacterially-induced osteolysis remains elusive. Here, we show that matrix-embedded osteocytes stimulated with bacterial…”
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Sclerostin Directly Stimulates Osteocyte Synthesis of Fibroblast Growth Factor-23 by Ito, Nobuaki, Prideaux, Matthew, Wijenayaka, Asiri R., Yang, Dongqing, Ormsby, Renee T., Bonewald, Lynda F., Atkins, Gerald J.

“…Osteocyte produced fibroblast growth factor 23 (FGF23) is the key regulator of serum phosphate (Pi) homeostasis. The interplay between parathyroid hormone…”
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Isolation and culture of primary osteocytes from the long bones of skeletally mature and aged mice by Stern, Amber Rath, Stern, Matthew M, Van Dyke, Mark E, Jähn, Katharina, Prideaux, Matthew, Bonewald, Lynda F

“…The purpose of this work was to establish a methodology to enable the isolation and study of osteocytes from skeletally mature young (4-month-old) and old…”
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Posttranslational processing of FGF23 in osteocytes during the osteoblast to osteocyte transition by Yamamoto, Hiroyuki, Ramos-Molina, Bruno, Lick, Adam N, Prideaux, Matthew, Albornoz, Valeria, Bonewald, Lynda, Lindberg, Iris

“…Abstract FGF23 is an O-glycosylated circulating peptide hormone with a critical role in phosphate homeostasis; it is inactivated by cellular proprotein…”
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SaOS2 Osteosarcoma Cells as an In Vitro Model for Studying the Transition of Human Osteoblasts to Osteocytes by Prideaux, Matthew, Wijenayaka, Asiri R., Kumarasinghe, Duminda D., Ormsby, Renee T., Evdokiou, Andreas, Findlay, David M., Atkins, Gerald J.

“…The central importance of osteocytes in regulating bone homeostasis is becoming increasingly apparent. However, the study of these cells has been restricted by…”
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Extracellular matrix mineralization promotes E11/gp38 glycoprotein expression and drives osteocytic differentiation by Prideaux, Matthew, Loveridge, Nigel, Pitsillides, Andrew A, Farquharson, Colin

“…Osteocytes are terminally differentiated osteoblasts which reside in a mineralized extracellular matrix (ECM). The factors that regulate this differentiation…”
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Age and sex effects on FGF23-mediated response to mild phosphate challenge by Tippen, Samantha P., Noonan, Megan L., Ni, Pu, Metzger, Corinne E., Swallow, Elizabeth A., Sacks, Spencer A., Chen, Neal X., Thompson, William R., Prideaux, Matthew, Atkins, Gerald J., Moe, Sharon M., Allen, Matthew R., White, Kenneth E.

“…During aging, there is a normal and mild loss in kidney function that leads to abnormalities of the kidney-bone metabolic axis. In the setting of increased…”
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Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner by Shimonty, Anika, Pin, Fabrizio, Prideaux, Matthew, Peng, Gang, Huot, Joshua, Kim, Hyeonwoo, Rosen, Clifford J, Spiegelman, Bruce M, Bonewald, Lynda F

“…Irisin, released from exercised muscle, has been shown to have beneficial effects on numerous tissues but its effects on bone are unclear. We found significant…”
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Isolation and Functional Analysis of an Immortalized Murine Cementocyte Cell Line, IDG‐CM6 by Zhao, Ning, Nociti, Francisco H, Duan, Peipei, Prideaux, Matthew, Zhao, Hong, Foster, Brian L, Somerman, Martha J, Bonewald, Lynda F

“…ABSTRACT The dental cementum covering the tooth root is similar to bone in several respects but remains poorly understood in terms of development and…”
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Generation of two multipotent mesenchymal progenitor cell lines capable of osteogenic, mature osteocyte, adipogenic, and chondrogenic differentiation by Prideaux, Matthew, Wright, Christian S., Noonan, Megan L., Yi, Xin, Clinkenbeard, Erica L., Mevel, Elsa, Wheeler, Jonathan A., Byers, Sharon, Wijenayaka, Asiri R., Gronthos, Stan, Sankar, Uma, White, Kenneth E., Atkins, Gerald J., Thompson, William R.

“…Mesenchymal progenitors differentiate into several tissues including bone, cartilage, and adipose. Targeting these cells in vivo is challenging, making…”
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Isolation of osteocytes from human trabecular bone by Prideaux, Matthew, Schutz, Christine, Wijenayaka, Asiri R, Findlay, David M, Campbell, David G, Solomon, Lucian B, Atkins, Gerald J

“…Abstract Osteocytes are essential regulators of bone homeostasis. However, they are difficult to study due to their location within the bone mineralised…”
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Parathyroid Hormone Induces Bone Cell Motility and Loss of Mature Osteocyte Phenotype through L-Calcium Channel Dependent and Independent Mechanisms by Prideaux, Matthew, Dallas, Sarah L, Zhao, Ning, Johnsrud, Erica D, Veno, Patricia A, Guo, Dayong, Mishina, Yuji, Harris, Stephen E, Bonewald, Lynda F

“…Parathyroid Hormone (PTH) can exert both anabolic and catabolic effects on the skeleton, potentially through expression of the PTH type1 receptor (PTH1R),…”
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An osteoprotegerin-like peptidomimetic inhibits osteoclastic bone resorption and osteolytic bone disease in myeloma by HEATH, Deborah J, VANDERKERKEN, Karin, XIN CHENG, GALLAGHER, Orla, PRIDEAUX, Matthew, MURALI, Ramachandran, CROUCHER, Peter I

“…Multiple myeloma is a B-cell malignancy characterized by the uncontrolled growth of plasma cells in the bone marrow and the development of osteolytic bone…”
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Differential Iron Requirements for Osteoblast and Adipocyte Differentiation by Edwards, Daniel F., Miller, Christopher J., Quintana‐Martinez, Arelis, Wright, Christian S., Prideaux, Matthew, Atkins, Gerald J., Thompson, William R., Clinkenbeard, Erica L.

“…ABSTRACT Bone marrow mesenchymal progenitor cells are precursors for various cell types including osteoblasts, adipocytes, and chondrocytes. The external…”
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Regulation of the Osteocyte Secretome with Aging and Disease by Kitase, Yukiko, Prideaux, Matthew

“…As the most numerous and long-lived of all bone cells, osteocytes have essential functions in regulating skeletal health. Through the lacunar-canalicular…”
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Osteocytes: The master cells in bone remodelling by Prideaux, Matthew, Findlay, David M, Atkins, Gerald J

“…Highlights • Osteocytes regulate bone formation through a number of interacting signalling pathways. • Osteocytes regulate bone resorption through controlling…”
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The ‘bIUreactor’: An Open-Source 3D Tissue Research Platform by Butch, Elizabeth, Prideaux, Matthew, Holland, Mark, Phan, Justin-Thuy, Trent, Cole, Soon, Victor, Hutchins, Gary, Smith, Lester

“…We developed the open-source bIUreactor research platform for studying 3D structured tissues. The versatile and modular platform allows a researcher to…”
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