Search Results - "Prichard, Mark N"

New therapies for human cytomegalovirus infections by Britt, William J., Prichard, Mark N.

“…The recent approval of letermovir marks a new era of therapy for human cytomegalovirus (HCMV) infections, particularly for the prevention of HCMV disease in…”
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Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir by Prichard, Mark N.

“…The serine/threonine kinase expressed by human cytomegalovirus from gene UL97 phosphorylates the antiviral drug ganciclovir, but its biological function is the…”
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Current and future therapies for herpes simplex virus infections: mechanism of action and drug resistance by James, Scott H, Prichard, Mark N

“…•We review the current state of anti-HSV chemotherapy, including resistance rates.•We highlight novel agents under investigation for the treatment of HSV…”
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Vertical mother‐to‐infant transmission of herpes simplex virus 2 is correlated with tropism due to mutations in viral UL13 by Shiraki, Kimiyasu, Daikoku, Tohru, Prichard, Mark N., Matsuo, Koma, Okuda, Tomoko, Yoshida, Yoshihiro, Takemoto, Masaya, Takeuchi, Kenji, Sada, Kiyonao, Whitley, Richard, Kawana, Takashi

“…Although neonates are commonly exposed to vaginal herpes simplex virus (HSV)‐2, neonatal herpes is rare. Therefore, we analyzed paired infant and maternal…”
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Triple combination of amantadine, ribavirin, and oseltamivir is highly active and synergistic against drug resistant influenza virus strains in vitro by Nguyen, Jack T, Hoopes, Justin D, Le, Minh H, Smee, Donald F, Patick, Amy K, Faix, Dennis J, Blair, Patrick J, de Jong, Menno D, Prichard, Mark N, Went, Gregory T

“…The rapid emergence and subsequent spread of the novel 2009 Influenza A/H1N1 virus (2009 H1N1) has prompted the World Health Organization to declare the first…”
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New Small Molecule Entry Inhibitors Targeting Hemagglutinin-Mediated Influenza A Virus Fusion by Basu, Arnab, Antanasijevic, Aleksandar, Wang, Minxiu, Li, Bing, Mills, Debra M, Ames, Jessica A, Nash, Peter J, Williams, John D, Peet, Norton P, Moir, Donald T, Prichard, Mark N, Keith, Kathy A, Barnard, Dale L, Caffrey, Michael, Rong, Lijun, Bowlin, Terry L

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Virucidal activity of polysaccharide extracts from four algal species against herpes simplex virus by Harden, Emma A., Falshaw, Ruth, Carnachan, Susan M., Kern, Earl R., Prichard, Mark N.

“…Herpes simplex virus types 1 and 2 (HSV-1, HSV-2) infections are common, but can cause serious infections in neonates and the immunocompromised. Drugs…”
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Differential properties of cytomegalovirus pUL97 kinase isoforms affect viral replication and maribavir susceptibility by Webel, Rike, Hakki, Morgan, Prichard, Mark N, Rawlinson, William D, Marschall, Manfred, Chou, Sunwen

“…The human cytomegalovirus (HCMV)-encoded kinase pUL97 is required for efficient viral replication. Previous studies described two isoforms of pUL97, the…”
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The search for new therapies for human cytomegalovirus infections by Prichard, Mark N., Kern, Earl R.

“…Ganciclovir (GCV), the therapy of choice for human cytomegalovirus (CMV) infections and foscarnet, a drug used to treat GCV-resistant CMV infections was…”
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The Natural Antimicrobial Peptide Subtilosin Acts Synergistically with Glycerol Monolaurate, Lauric Arginate, and ε-Poly-l-Lysine against Bacterial Vaginosis-Associated Pathogens but Not Human Lactobacilli by SUTYAK NOLL, Katia, PRICHARD, Mark N, KHAYKIN, Arkady, SINKO, Patrick J, CHIKINDAS, Michael L

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Triple Combination of Oseltamivir, Amantadine, and Ribavirin Displays Synergistic Activity against Multiple Influenza Virus Strains In Vitro by NGUYEN, Jack T, HOOPES, Justin D, SMEE, Donald F, PRICHARD, Mark N, DRIEBE, Elizabeth M, ENGELTHALER, David M, LE, Minh H, KEIM, Paul S, SPENCE, R. Paul, WENT, Gregory T

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Synergistic Efficacy of the Combination of ST-246 with CMX001 against Orthopoxviruses by QUENELLE, Debra C, PRICHARD, Mark N, KEITH, Kathy A, HRUBY, Dennis E, JORDAN, Robert, PAINTER, George R, ROBERTSON, Alice, KERN, Earl R

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CMX001 Potentiates the Efficacy of Acyclovir in Herpes Simplex Virus Infections by Prichard, Mark N, Kern, Earl R, Hartline, Caroll B, Lanier, E. Randall, Quenelle, Debra C

“…Although acyclovir (ACV) has proven to be of value in the therapy of certain herpes simplex virus (HSV) infections, there is a need for more effective…”
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Synthesis and Antiviral Activities of Methylenecyclopropane Analogs with 6-Alkoxy and 6-Alkylthio Substitutions That Exhibit Broad-Spectrum Antiviral Activity against Human Herpesviruses by Prichard, Mark N, Williams, John D, Komazin-Meredith, Gloria, Khan, Atiyya R, Price, Nathan B, Jefferson, Geraldine M, Harden, Emma A, Hartline, Caroll B, Peet, Norton P, Bowlin, Terry L

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A Possible Pitfall in Acyclovir Prophylaxis for Recurrent Herpetic Keratitis? by James, Scott H., Prichard, Mark N.

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Selection and Recombinant Phenotyping of a Novel CMX001 and Cidofovir Resistance Mutation in Human Cytomegalovirus by JAMES, Scott H, PRICE, Nathan B, HARTLINE, Caroll B, RANDALL LANIER, E, PRICHARD, Mark N

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Human Cytomegalovirus UL97 Kinase Is Involved in the Mechanism of Action of Methylenecyclopropane Analogs with 6-Ether and -Thioether Substitutions by KOMAZIN-MEREDITH, Gloria, SUNWEN CHOU, PRICHARD, Mark N, HARTLINE, Caroll B, CARDINALE, Steven C, COMEAU, Katelyn, WILLIAMS, John D, KHAN, Atiyya R, PEET, Norton P, BOWLIN, Terry L

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Human cytomegalovirus UL97 kinase alters the accumulation of CDK1 by GILL, Rachel B, JAMES, Scott H, PRICHARD, Mark N

“…The UL97 protein kinase is a serine/threonine kinase expressed by human cytomegalovirus (CMV) that phosphorylates ganciclovir. An investigation of the…”
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Human Cytomegalovirus UL97 Kinase Activity Is Required for the Hyperphosphorylation of Retinoblastoma Protein and Inhibits the Formation of Nuclear Aggresomes by PRICHARD, Mark N, SZTUL, Elizabeth, KERN, Earl R, DAILY, Shannon L, PERRY, Amie L, FREDERICK, Samuel L, GILL, Rachel B, HARTLINE, Caroll B, STREBLOW, Daniel N, VARNUM, Susan M, SMITH, Richard D

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Genotypic and Phenotypic Diversity of Herpes Simplex Virus 2 within the Infected Neonatal Population by Akhtar, Lisa N, Bowen, Christopher D, Renner, Daniel W, Pandey, Utsav, Della Fera, Ashley N, Kimberlin, David W, Prichard, Mark N, Whitley, Richard J, Weitzman, Matthew D, Szpara, Moriah L

“…More than 14,000 neonates are infected with herpes simplex virus (HSV) annually. Approximately half display manifestations limited to the skin, eyes, or mouth…”
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