Search Results - "Price, Laura A."

Conformationally Constrained ortho-Anilino Diaryl Ureas: Discovery of 1‑(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y1 Antagonist by Qiao, Jennifer X, Wang, Tammy C, Ruel, Réjean, Thibeault, Carl, L’Heureux, Alexandre, Schumacher, William A, Spronk, Steven A, Hiebert, Sheldon, Bouthillier, Gilles, Lloyd, John, Pi, Zulan, Schnur, Dora M, Abell, Lynn M, Hua, Ji, Price, Laura A, Liu, Eddie, Wu, Qimin, Steinbacher, Thomas E, Bostwick, Jeffrey S, Chang, Ming, Zheng, Joanna, Gao, Qi, Ma, Baoqing, McDonnell, Patricia A, Huang, Christine S, Rehfuss, Robert, Wexler, Ruth R, Lam, Patrick Y. S

“…Preclinical antithrombotic efficacy and bleeding models have demonstrated that P2Y1 antagonists are efficacious as antiplatelet agents and may offer a safety…”
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Biomarker optimization to track the antithrombotic and hemostatic effects of clopidogrel in rats by Schumacher, William A, Bostwick, Jeffrey S, Ogletree, Martin L, Stewart, Anne B, Steinbacher, Thomas E, Hua, Ji, Price, Laura A, Wong, Pancras C, Rehfuss, Robert P

“…We determined the dose response of the ADP antagonist clopidogrel (0.3-50 mg/kg p.o.) in rat models of thrombosis and provoked bleeding and correlated these…”
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ORK1, a potassium-selective leak channel with two pore domains cloned from Drosophila melanogaster by expression in Saccharomyces cerevisiae. [Erratum: Jan 5, 1999, v. 96 (1), p. 318.] by Goldstein, S.A.N. (Yale University School of Medicine, New Haven, CT.), Price, L.A, Rosenthal, D.N, Pausch, M.H

“…A K+ channel gene has been cloned from Drosophila melanogaster by complementation in Saccharomyces cerevisiae cells defective for K+ uptake. Naturally…”
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Discovery of 4‑Aryl-7-Hydroxyindoline-Based P2Y1 Antagonists as Novel Antiplatelet Agents by Yang, Wu, Wang, Yufeng, Lai, Amy, Qiao, Jennifer X, Wang, Tammy C, Hua, Ji, Price, Laura A, Shen, Hong, Chen, Xue-qing, Wong, Pancras, Crain, Earl, Watson, Carol, Huang, Christine S, Seiffert, Dietmar A, Rehfuss, Robert, Wexler, Ruth R, Lam, Patrick Y. S

“…Adenosine diphosphate (ADP)-mediated platelet aggregation is signaled through two distinct G protein-coupled receptors (GPCR) on the platelet surface: P2Y12…”
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Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson’s Disease by Roecker, Anthony J., Schirripa, Kathy M., Loughran, H. Marie, Tong, Ling, Liang, Tao, Fillgrove, Kerry L., Kuo, Yuhsin, Bleasby, Kelly, Collier, Hannah, Altman, Michael D., Ford, Melissa C., Drolet, Robert E., Cosden, Mali, Jinn, Sarah, Hatcher, Nathan G., Yao, Lihang, Kandebo, Monika, Vardigan, Joshua D., Flick, Rosemarie B., Liu, Xiaomei, Minnick, Christina, Price, Laura A., Watt, Marla L., Lemaire, Wei, Burlein, Christine, Adam, Gregory C., Austin, Lauren A., Marcus, Jacob N., Smith, Sean M., Fraley, Mark E.

“…Parkinson’s disease is the second most prevalent progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia…”
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New azole antagonists with high affinity for the P2Y(1) receptor by Ruel, Réjean, L'Heureux, Alexandre, Thibeault, Carl, Daris, Jean-Paul, Martel, Alain, Price, Laura A, Wu, Qimin, Hua, Ji, Wexler, Ruth R, Rehfuss, Robert, Lam, Patrick Y S

“…Five-membered-ring heterocyclic urea mimics have been found to be potent and selective antagonists of the P2Y1 receptor. SAR of the various heterocyclic…”
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New azole antagonists with high affinity for the P2Y1 receptor by Ruel, Réjean, L’Heureux, Alexandre, Thibeault, Carl, Daris, Jean-Paul, Martel, Alain, Price, Laura A., Wu, Qimin, Hua, Ji, Wexler, Ruth R., Rehfuss, Robert, Lam, Patrick Y.S.

“…Five-membered-ring heterocyclic urea mimics have been found to be potent and selective antagonists of the P2Y1 receptor. SAR of the various heterocyclic…”
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2-Amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y1 receptor antagonists by Hu, Carol H., Qiao, Jennifer X., Han, Ying, Wang, Tammy C., Hua, Ji, Price, Laura A., Wu, Qimin, Shen, Hong, Huang, Christine S., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y.S.

“…Blockade of the P2Y1 receptor is important to the treatment of thrombosis with potentially improved safety margins compared with P2Y12 receptor antagonists…”
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Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent by Jeon, Yoon T, Yang, Wu, Qiao, Jennifer X, Li, Ling, Ruel, Rejean, Thibeault, Carl, Hiebert, Sheldon, Wang, Tammy C, Wang, Yufeng, Liu, Yajun, Clark, Charles G, Wong, Henry S, Zhu, Juliang, Wu, Dauh-Rurng, Sun, Dawn, Chen, Bang-Chi, Mathur, Arvind, Chacko, Silvi A, Malley, Mary, Chen, Xue-Qing, Shen, Hong, Huang, Christine S, Schumacher, William A, Bostwick, Jeffrey S, Stewart, Anne B, Price, Laura A, Hua, Ji, Li, Danshi, Levesque, Paul C, Seiffert, Dietmar A, Rehfuss, Robert, Wexler, Ruth R, Lam, Patrick Y S

“…Spiropiperidine indoline-substituted diaryl ureas had been identified as antagonists of the P2Y1 receptor. Enhancements in potency were realized through the…”
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Discovery of diarylurea P2Y(1) antagonists with improved aqueous solubility by Wang, Tammy C, Qiao, Jennifer X, Clark, Charles G, Jua, Ji, Price, Laura A, Wu, Qimin, Chang, Ming, Zheng, Joanna, Huang, Christine S, Everlof, Gerry, Schumacher, William A, Wong, Pancras C, Seiffert, Dietmar A, Stewart, Anne B, Bostwick, Jeffrey S, Crain, Earl J, Watson, Carol A, Rehfuss, Robert, Wexler, Ruth R, Lam, Patrick Y S

“…Preclinical data suggests that P2Y1 antagonists, such as diarylurea compound 1, may provide antithrombotic efficacy similar to P2Y12 antagonists and may have…”
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Discovery of diarylurea P2Y1 antagonists with improved aqueous solubility by Wang, Tammy C., Qiao, Jennifer X., Clark, Charles G., Jua, Ji, Price, Laura A., Wu, Qimin, Chang, Ming, Zheng, Joanna, Huang, Christine S., Everlof, Gerry, Schumacher, William A., Wong, Pancras C., Seiffert, Dietmar A., Stewart, Anne B., Bostwick, Jeffrey S., Crain, Earl J., Watson, Carol A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y.S.

“…Preclinical data suggests that P2Y1 antagonists, such as diarylurea compound 1, may provide antithrombotic efficacy similar to P2Y12 antagonists and may have…”
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Potent P2Y1 urea antagonists bearing various cyclic amine scaffolds by Ruel, Réjean, L’Heureux, Alexandre, Thibeault, Carl, Lapointe, Philippe, Martel, Alain, Qiao, Jennifer X., Hua, Ji, Price, Laura A., Wu, Qimin, Chang, Ming, Zheng, Joanna, Huang, Christine S., Wexler, Ruth R., Rehfuss, Robert, Lam, Patrick Y.S.

“…A number of new amine scaffolds with good inhibitory activity in the ADP-induced platelet aggregation assay have been found to be potent antagonists of the…”
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4-Benzothiazole-7-hydroxyindolinyl Diaryl Ureas Are Potent P2Y1 Antagonists with Favorable Pharmacokinetics: Low Clearance and Small Volume of Distribution by Qiao, Jennifer X., Wang, Tammy C., Hiebert, Sheldon, Hu, Carol H., Schumacher, William A., Spronk, Steven A., Clark, Charles G., Han, Ying, Hua, Ji, Price, Laura A., Shen, Hong, Chacko, Silvi A., Everlof, Gerry, Bostwick, Jeffrey S., Steinbacher, Thomas E., Li, Yi-Xin, Huang, Christine S., Seiffert, Dietmar A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y. S.

“…Current antithrombotic discovery efforts target compounds that are highly efficacious in thrombus reduction with less bleeding liability than the standard of…”
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Functional coupling of a mammalian somatostatin receptor to the yeast pheromone response pathway by Price, Laura A., Kajkowski, Eileen M., Hadcock, John R., Ozenberger, Bradley A., Pausch, Mark H.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A linear hexapeptide somatostatin antagonist blocks somatostatin activity in vitro and influences growth hormone release in rats by Baumbach, W R, Carrick, T A, Pausch, M H, Bingham, B, Carmignac, D, Robinson, I C, Houghten, R, Eppler, C M, Price, L A, Zysk, J R

“…Somatostatin (SRIF) is the main inhibitory peptide regulating growth hormone (GH) secretion. It has been difficult to establish the role of endogenous SRIF…”
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Discovery of 2-(Phenoxypyridine)-3-phenylureas as Small Molecule P2Y 1 Antagonists by Chao, Hannguang, Turdi, Huji, Herpin, Timothy F., Roberge, Jacques Y., Liu, Yalei, Schnur, Dora M., Poss, Michael A., Rehfuss, Robert, Hua, Ji, Wu, Qimin, Price, Laura A., Abell, Lynn M., Schumacher, William A., Bostwick, Jeffrey S., Steinbacher, Thomas E., Stewart, Anne B., Ogletree, Martin L., Huang, Christine S., Chang, Ming, Cacace, Angela M., Arcuri, Maredith J., Celani, Deborah, Wexler, Ruth R., Lawrence, R. Michael

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2-Amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y sub(1) receptor antagonists by Hu, Carol H, Qiao, Jennifer X, Han, Ying, Wang, Tammy C, Hua, Ji, Price, Laura A, Wu, Qimin, Shen, Hong, Huang, Christine S, Rehfuss, Robert, Wexler, Ruth R, Lam, Patrick YS

“…Blockade of the P2Y sub(1) receptor is important to the treatment of thrombosis with potentially improved safety margins compared with P2Y sub(12) receptor…”
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Discovery of 4-Aryl-7-Hydroxyindoline-Based P2Y 1 Antagonists as Novel Antiplatelet Agents by Yang, Wu, Wang, Yufeng, Lai, Amy, Qiao, Jennifer X., Wang, Tammy C., Hua, Ji, Price, Laura A., Shen, Hong, Chen, Xue-qing, Wong, Pancras, Crain, Earl, Watson, Carol, Huang, Christine S., Seiffert, Dietmar A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y. S.

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Identification of 1-{2-[4-chloro-1′-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4′-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y1 antagonist as an antiplatelet agent by Jeon, Yoon T., Yang, Wu, Qiao, Jennifer X., Li, Ling, Ruel, Rejean, Thibeault, Carl, Hiebert, Sheldon, Wang, Tammy C., Wang, Yufeng, Liu, Yajun, Clark, Charles G., Wong, Henry S., Zhu, Juliang, Wu, Dauh-Rurng, Sun, Dawn, Chen, Bang-Chi, Mathur, Arvind, Chacko, Silvi A., Malley, Mary, Chen, Xue-Qing, Shen, Hong, Huang, Christine S., Schumacher, William A., Bostwick, Jeffrey S., Stewart, Anne B., Price, Laura A., Hua, Ji, Li, Danshi, Levesque, Paul C., Seiffert, Dietmar A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y.S.

“…Spiropiperidine indoline-substituted diaryl ureas had been identified as antagonists of the P2Y1 receptor. Enhancements in potency were realized through the…”
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Conformationally Constrained ortho- Anilino Diaryl Ureas: Discovery of 1-(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y 1 Antagonist by Qiao, Jennifer X., Wang, Tammy C., Ruel, Réjean, Thibeault, Carl, L’Heureux, Alexandre, Schumacher, William A., Spronk, Steven A., Hiebert, Sheldon, Bouthillier, Gilles, Lloyd, John, Pi, Zulan, Schnur, Dora M., Abell, Lynn M., Hua, Ji, Price, Laura A., Liu, Eddie, Wu, Qimin, Steinbacher, Thomas E., Bostwick, Jeffrey S., Chang, Ming, Zheng, Joanna, Gao, Qi, Ma, Baoqing, McDonnell, Patricia A., Huang, Christine S., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y. S.

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