Influences of activity wheel access on the body temperature response to MDMA and methamphetamine

Recreational ingestion of the drug 3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) can result in pathologically elevated body temperature and even death in humans. Such incidents are relatively rare which makes it difficult to identify the relative contributions of specific environmental and sit...

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Published in:	Pharmacology, biochemistry and behavior Vol. 99; no. 3; pp. 295 - 300
Main Authors:	Gilpin, N.W., Wright, M.J., Dickinson, G., Vandewater, S.A., Price, J.U., Taffe, M.A.
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Inc 01-09-2011 Elsevier
Subjects:	Animals Behavior, Animal - drug effects Behavior, Animal - physiology Biological and medical sciences Body Temperature - drug effects Body Temperature - physiology Dose-Response Relationship, Drug Ecstasy Fever - chemically induced Fever - physiopathology Hyperthermia Locomotor Male Medical sciences Methamphetamine - pharmacology Motor Activity - drug effects Motor Activity - physiology N-Methyl-3,4-methylenedioxyamphetamine - pharmacology Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Wistar Stimulant Thermoregulation Ecstasy Thermoregulation Stimulant Locomotor Hyperthermia Amphetamine derivatives Accessibility CNS stimulant Psychotropic Body temperature Metamfetamine Sympathomimetic Locomotion Treatment Drug of abuse Recreational drug
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Summary:	Recreational ingestion of the drug 3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) can result in pathologically elevated body temperature and even death in humans. Such incidents are relatively rare which makes it difficult to identify the relative contributions of specific environmental and situational factors. Although animal models have been used to explore several aspects of MDMA-induced hyperthermia and it is regularly hypothesized that prolonged physical activity (e.g., dancing) in the nightclub environment increases risk, this has never been tested directly. In this study the rectal temperature of male Wistar rats was monitored after challenge with doses of MDMA and methamphetamine (MA), another drug frequently ingested in the rave/nightclub environment, either with or without access to an activity wheel. Results showed that wheel activity did not modify the hyperthermia produced by 10.0mg/kg MDMA. However, individual correlations were observed in which wheel activity levels after a locomotor stimulant dose of MDMA were positively related to body temperature change and lethal outcome. A modest increase in the maximum body temperature observed after 5.6mg/kg MA was caused by wheel access but this was mostly attributable to a drop in temperature relative to vehicle treatment in the absence of wheel activity. These results suggest that nightclub dancing in the human Ecstasy consumer may not be a significant factor in medical emergencies. ► Determination of the role of repetitive exercise on MDMA/METH hyperthermia. ► Use of activity wheel to model rave dancing in rodents. ► Data show no mean effect of wheel running on hyperthermia. ► Rare individual mortality points to interaction with wheel running and MDMA.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0091-3057 1873-5177 1873-5177
DOI:	10.1016/j.pbb.2011.05.006