Search Results - "Price, Antionette"
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Synergistic activity of mTORC1/2 kinase and MEK inhibitors suppresses pediatric low-grade glioma tumorigenicity and vascularity
Published in Neuro-oncology (Charlottesville, Va.) (15-04-2020)“…Abstract Background Pediatric low-grade glioma (pLGG) is the most common childhood brain tumor. Many patients with unresectable or recurrent/refractory tumors…”
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Nuclear Localization of Human SOD1 in Motor Neurons in Mouse Model and Patient Amyotrophic Lateral Sclerosis: Possible Links to Cholinergic Phenotype, NADPH Oxidase, Oxidative Stress, and DNA Damage
Published in International journal of molecular sciences (22-08-2024)“…Amyotrophic lateral sclerosis (ALS) is a fatal disease that causes degeneration of motor neurons (MNs) and paralysis. ALS can be caused by mutations in the…”
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Increased Tau Expression Correlates With IDH Mutation in Infiltrating Gliomas and Impairs Cell Migration
Published in Journal of neuropathology and experimental neurology (01-05-2020)“…Abstract Although the microtubule-associated protein tau is well studied in human neurodegeneration, the role of tau in neoplastic brain diseases is not well…”
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RNA‐sequencing highlights differential regulated pathways involved in cell cycle and inflammation in orbitofacial neurofibromas
Published in Brain pathology (Zurich, Switzerland) (01-01-2022)“…Although most commonly benign, neurofibromas (NFs) can have devastating functional and cosmetic effects in addition to the possibility of malignant…”
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LGG-51. METABOLIC PROFILING IN PEDIATRIC LOW GRADE GLIOMA IDENTIFIES GLUTATHIONE DEPLETION AFTER MTORC1 INHIBITION AND VALIDATES EVEROLIMUS AND CARBOPLATIN AS A POTENTIAL COMBINATION THERAPY
Published in Neuro-oncology (Charlottesville, Va.) (22-06-2018)“…Abstract The mTOR pathway contributes to the tumorigenicity of aggressive pediatric low grade glioma (pLGG) and TORC1 inhibitors have demonstrated efficacy in…”
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