Search Results - "Prevot, D"

Median raphe serotonin neurons promote anxiety-like behavior via inputs to the dorsal hippocampus by Abela, Andrew R., Browne, Caleb J., Sargin, Derya, Prevot, Thomas D., Ji, Xiao Dong, Li, Zhaoxia, Lambe, Evelyn K., Fletcher, Paul J.

“…Anxiety disorders may be mediated in part by disruptions in serotonin (5-hydroxytryptamine, 5-HT) system function. Behavioral measures of approach-avoidance…”
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Behavioral Deficits Induced by Somatostatin-Positive GABA Neuron Silencing Are Rescued by Alpha 5 GABA-A Receptor Potentiation by Fee, Corey, Prevot, Thomas D, Misquitta, Keith, Knutson, Daniel E, Li, Guanguan, Mondal, Prithu, Cook, James M, Banasr, Mounira, Sibille, Etienne

“…Abstract Introduction Deficits in somatostatin-positive gamma-aminobutyric acid interneurons (SST+ GABA cells) are commonly reported in human studies of mood…”
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Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits by Yao, Heng Kang, Guet-McCreight, Alexandre, Mazza, Frank, Moradi Chameh, Homeira, Prevot, Thomas D., Griffiths, John D., Tripathy, Shreejoy J., Valiante, Taufik A., Sibille, Etienne, Hay, Etay

“…Cortical processing depends on finely tuned excitatory and inhibitory connections in neuronal microcircuits. Reduced inhibition by somatostatin-expressing…”
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Synthesis and Receptor Binding Studies of α5 GABAAR Selective Novel Imidazodiazepines Targeted for Psychiatric and Cognitive Disorders by Sharmin, Dishary, Mian, Md Yeunus, Marcotte, Michael, Prevot, Thomas D., Sibille, Etienne, Witkin, Jeffrey M., Cook, James M.

“…GABA mediates inhibitory actions through various GABAA receptor subtypes, including 19 subunits in human GABAAR. Dysregulation of GABAergic neurotransmission…”
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GL-II-73, a Positive Allosteric Modulator of α5GABAA Receptors, Reverses Dopamine System Dysfunction Associated with Pilocarpine-Induced Temporal Lobe Epilepsy by McCoy, Alexandra M., Prevot, Thomas D., Sharmin, Dishary, Cook, James M., Sibille, Etienne L., Lodge, Daniel J.

“…Although seizures are a hallmark feature of temporal lobe epilepsy (TLE), psychiatric comorbidities, including psychosis, are frequently associated with TLE…”
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Brain structure and working memory adaptations associated with maturation and aging in mice by Clifford, Kevan P, Miles, Amy E, Prevot, Thomas D, Misquitta, Keith A, Ellegood, Jacob, Lerch, Jason P, Sibille, Etienne, Nikolova, Yuliya S, Banasr, Mounira

“…As the population skews toward older age, elucidating mechanisms underlying human brain aging becomes imperative. Structural MRI has facilitated non-invasive…”
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GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential by Dharavath, Ravinder Naik, Pina-Leblanc, Celeste, Tang, Victor M, Sloan, Matthew E, Nikolova, Yuliya S, Pangarov, Peter, Ruocco, Anthony C, Shield, Kevin, Voineskos, Daphne, Blumberger, Daniel M, Boileau, Isabelle, Bozinoff, Nikki, Gerretsen, Philip, Vieira, Erica, Melamed, Osnat C, Sibille, Etienne, Quilty, Lena C, Prevot, Thomas D

“…Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the global disease burden, contributes substantially to societal and…”
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In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression by Guet-McCreight, Alexandre, Chameh, Homeira Moradi, Mazza, Frank, Prevot, Thomas D., Valiante, Taufik A., Sibille, Etienne, Hay, Etay

“…Reduced inhibition by somatostatin-expressing interneurons is associated with depression. Administration of positive allosteric modulators of α5…”
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Hippocampal α5-GABAA Receptors Modulate Dopamine Neuron Activity in the Rat Ventral Tegmental Area by Perez, Stephanie M., McCoy, Alexandra M., Prevot, Thomas D., Mian, Md Yeunus, Carreno, Flavia R., Frazer, Alan, Cook, James M., Sibille, Etienne, Lodge, Daniel J.

“…Aberrant dopamine neuron activity is attributable to hyperactivity in hippocampal subfields driving a pathological increase in dopamine neuron activity, which…”
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Lack of direct insulin-like action of visfatin/Nampt/PBEF1 in human adipocytes by Wanecq, E., Prévot, D., Carpéné, C.

“…Visfatin, a protein identified as a secretion product of visceral fat in humans and mice, is also expressed in different anatomical locations, and is known as…”
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Neurotrophic effects of potentiating gaba-mediated dendritic inhibition by Prevot, Thomas D, Sibille, Etienne

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Synthesis of chiral GABAA receptor subtype selective ligands as potential agents to treat schizophrenia as well as depression by Li, Guanguan, Stephen, Michael R., Kodali, Revathi, Zahn, Nicolas M., Poe, Michael M., Tiruveedhula, V. V. N. Phani Babu, Huber, Alec T., Schussman, Melissa K., Qualmann, Krista, Panhans, Cristina M., Raddatz, Nicholas J., Baker, David A., Prevot, Thomas D., Banasr, Mounira, Sibille, Etienne, Arnold, Leggy A., Cook, James M.

“…A series of novel imidazobenzodiazepine analogs of the lead chiral ligand SH-053–2’F- S -CH 3 ( 2 ), an α2/α3/α5 (Bz)GABA (A)ergic receptor subtype selective…”
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Prolonged treatment with aminoguanidine strongly inhibits adipocyte semicarbazide-sensitive amine oxidase and slightly reduces fat deposition in obese Zucker rats by Prévot, D., Soltesz, Z., Abello, V., Wanecq, E., Valet, P., Unzeta, M., Carpéné, C.

“…Beneficial effects of aminoguanidine (AG) on diabetic vascular complications result from prevention of protein glycation, inhibition of inductible NO synthase,…”
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Saft Solutions For Full Geo Electric Propulsion by Prevot, D., Borthomieu, Y., Malet, F., Rebuffel, C., Carre, A., Cenac-Morthe, C.

“…Today, the full electric propulsion is becoming more commonly used on board geostationary satellites for the launch up to the Electrical Orbit Raising (EOR)…”
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Increased Neuronal DNA/RNA Oxidation in the Frontal Cortex of Mice Subjected to Unpredictable Chronic Mild Stress by Maluach, Alfred M., Misquitta, Keith A., Prevot, Thomas D., Fee, Corey, Sibille, Etienne, Banasr, Mounira, Andreazza, Ana C.

“…Background Chronic stress is implicated in the development of various psychiatric illnesses including major depressive disorder. Previous reports suggest that…”
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Performances of Saft Lithium-Ion Cells in LEO Cycling by Prevot, D., Borthomieu, Y., Ligneel, E., Hague, R., Peres, J-P., Cenac-Morthe, C.

“…Based on good LEO lifetime tests results, Saft proposes currently VES16 Lithium-ion for 12 years mission in Low Earth Orbit (LEO) up to 30%DoD or more within a…”
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Chronic Stress Alters Astrocyte Morphology in Mouse Prefrontal Cortex by Codeluppi, Sierra A, Chatterjee, Dipashree, Prevot, Thomas D, Bansal, Yashika, Misquitta, Keith A, Sibille, Etienne, Banasr, Mounira

“…Abstract Background Neuromorphological changes are consistently reported in the prefrontal cortex of patients with stress-related disorders and in rodent…”
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From serendipity to rational drug design in brain disorders: in silico, in vitro, and in vivo approaches by Oh, Hyunjung, Prevot, Thomas D., Newton, Dwight, Sibille, Etienne

“…Prolonged life expectancy and stressful lifestyles have increased the risk of developing neurological disorders, including neurodegenerative and psychiatric…”
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Symptomatic and neurotrophic effects of GABAA receptor positive allosteric modulation in a mouse model of chronic stress by Bernardo, Ashley, Lee, Philip, Marcotte, Michael, Mian, Md Yeunus, Rezvanian, Sepideh, Sharmin, Dishary, Kovačević, Aleksandra, Savić, Miroslav M, Cook, James M, Sibille, Etienne, Prevot, Thomas D

“…Chronic stress is a risk factor for Major Depressive Disorder (MDD), and in rodents, it recapitulates human behavioral, cellular and molecular changes. In MDD…”
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Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles by Prevot, Thomas D, Li, Guanguan, Vidojevic, Aleksandra, Misquitta, Keith A, Fee, Corey, Santrac, Anja, Knutson, Daniel E, Stephen, Michael Rajesh, Kodali, Revathi, Zahn, Nicolas M, Arnold, Leggy A, Scholze, Petra, Fisher, Janet L, Marković, Bojan D, Banasr, Mounira, Cook, James M, Savic, Miroslav, Sibille, Etienne

“…Altered gamma-aminobutyric acid (GABA) function is consistently reported in psychiatric disorders, normal aging, and neurodegenerative disorders and reduced…”
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