Search Results - "Preugschat, F"

In vitro processing of dengue virus type 2 nonstructural proteins NS2A, NS2B, and NS3 by PREUGSCHAT, F, CHEN-WEN YAO, STRAUSS, J. H

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Flavivirus enzyme-substrate interactions studied with chimeric proteinases: identification of an intragenic locus important for substrate recognition by PREUGSCHAT, F, LENCHES, E. M, STRAUSS, J. H

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Isolation and Characterization of a Xenopus laevis C Protein cDNA: Structure and Expression of a Heterogeneous Nuclear Ribonucleoprotein Core Protein by Preugschat, Frank, Wold, Barbara

“…The C proteins are major components of heterogeneous nuclear ribonucleoprotein complexes in nuclei of vertebrate cells. To begin to describe their structure,…”
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N-Phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amines as Potent and Selective Inhibitors of Glycogen Synthase Kinase 3 with Good Cellular Efficacy by Tavares, Francis X, Boucheron, Joyce A, Dickerson, Scott H, Griffin, Robert J, Preugschat, Frank, Thomson, Stephen A, Wang, Tony Y, Zhou, Hui-Qiang

“…Glycogen synthase kinase 3 regulates glycogen synthase, the rate-determining enzyme for glycogen synthesis. Liver and muscle glycogen synthesis is defective in…”
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Novel pyrazolopyrimidine derivatives as GSK-3 inhibitors by PEAT, Andrew J, BOUCHERON, Joyce A, WANG, Tony Y, ZHOU, Huiqiang Q, THOMSON, Stephen A, DICKERSON, Scott H, GARRIDO, Dulce, MILLS, Wendy, PECKHAM, Jennifer, PREUGSCHAT, Frank, SMALLEY, Terrence, SCHWEIKER, Stephanie L, WILSON, Jayme R

“…A series of [1-aryl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]arylhydrazones were discovered as novel inhibitors glycogen synthase kinase-3 (GSK-3). Based on initial…”
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Synthesis and evaluation of novel heterocyclic inhibitors of GSK-3 by Smalley, Terrence L., Peat, Andrew J., Boucheron, Joyce A., Dickerson, Scott, Garrido, Dulce, Preugschat, Frank, Schweiker, Stephanie L., Thomson, Stephen A., Wang, Tony Y.

“…Novel heterocyclic GSK-3 inhibitors based on a previously described template have been synthesized as a potential treatment for diabetes. Several compounds…”
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Discovery and in vitro evaluation of potent kinase inhibitors: Pyrido[1′,2′:1,5]pyrazolo[3,4- d]pyrimidines by Alberti, Michael J., Auten, Elizabeth P., Lackey, Karen E., McDonald, Octerloney B., Wood, Edgar R., Preugschat, Frank, Cutler, Geoffrey J., Kane-Carson, Laurie, Liu, Wei, Jung, David K.

“…The discovery, synthesis, and in vitro kinase profile of several pyrido[1′,2′:1,5]pyrazolo[3,4- d]pyrimidines as potent kinase inhibitors are discussed. The…”
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A Steady-state and Pre-steady-state Kinetic Analysis of the NTPase Activity Associated with the Hepatitis C Virus NS3 Helicase Domain by Preugschat, F, Averett, D R, Clarke, B E, Porter, D J

“…The helicase domain of hepatitis C virus NS3 (genotype 1b) was expressed in Escherichia coli and purified to homogeneity. The purified protein catalyzed the…”
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Dengue 2 virus NS2B and NS3 form a stable complex that can cleave NS3 within the helicase domain by Arias, C F, Preugschat, F, Strauss, J H

“…Flavivirus genomic RNA is translated into a large polyprotein that is processed into structural and nonstructural proteins. The N-termini of several…”
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Strand-Separating Activity of Hepatitis C Virus Helicase in the Absence of ATP by Porter, David J. T, Preugschat, Frank

“…HCV helicase [E(wt)] catalyzed strand separation of a short DNA duplex (F21:HF31) formed from a 5‘-hexachlorofluorescein-tagged 31-mer (HF31) and a…”
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Kinetic Analysis of the Effects of Mutagenesis of W501 and V432 of the Hepatitis C Virus NS3 Helicase Domain on ATPase and Strand-Separating Activity by Preugschat, Frank, Danger, Dana P, Carter, Luke H, Davis, Roderick G, Porter, David J. T

“…Two hydrophobic residues, W501 and V432, in the nucleic acid (NA) binding pocket of the HCV helicase domain (E) were mutagenized in an effort to investigate…”
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Processing of nonstructural proteins NS4A and NS4B of dengue 2 virus in vitro and in vivo by Preugschat, F, Strauss, J H

“…The production, from polyprotein precursors, of two hydrophobic nonstructural proteins of dengue 2 (DEN2) virus, NS4A and NS4B, was analyzed both in cell-free…”
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Isolation and characterization of a Xenopus laevis C protein cDNA: structure and expression of a heterogeneous nuclear ribonucleoprotein core protein by Preugschat, F, Wold, B

“…The C proteins are major components of heterogeneous nuclear ribonucleoprotein complexes in nuclei of vertebrate cells. To begin to describe their structure,…”
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Product release is the major contributor to kcat for the hepatitis C virus helicase-catalyzed strand separation of short duplex DNA by Porter, D J, Short, S A, Hanlon, M H, Preugschat, F, Wilson, J E, Willard, Jr, D H, Consler, T G

“…Hepatitis C virus (HCV) helicase catalyzes the ATP-dependent strand separation of duplex RNA and DNA containing a 3' single-stranded tail. Equilibrium and…”
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Product release is the major contributor to k sub(cat) for the hepatitis C virus helicase-catalyzed strand separation of short duplex DNA by Porter, DJT, Short, SA, Hanlon, M H, Preugschat, F, Wilson, JE, Willard, DH Jr, Consler, T G

“…Hepatitis C virus (HCV) helicase catalyzes the ATP-dependent strand separation of duplex RNA and DNA containing a 3' single-stranded tail. Equilibrium and…”
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Chimeric immunoglobulin light chains are secreted at different levels: influence of framework-1 amino acids by Horwitz, A H, Nadell, R, Preugschat, F, Better, M

“…Immunoglobulin light chain proteins are generally thought to be readily secreted without their corresponding heavy chains; non-secreted light chains have been…”
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Actin genes from the sea star Pisaster ochraceus by Kovesdi, I, Preugschat, F, Stuerzl, M, Smith, M J

“…Genomic and tube foot cDNA recombinant libraries have been prepared from the sea star Pisaster ochraceus. Three major classes of actin-bearing lambda phage…”
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