Search Results - "Pretti, Marco Antônio"
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Poor clinical outcome in metastatic melanoma is associated with a microRNA-modulated immunosuppressive tumor microenvironment
Published in Journal of translational medicine (05-02-2020)“…Interaction between malignant cells and immune cells that reside within the tumor microenvironment (TME) modulate different aspects of tumor development and…”
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Class I HLA Allele Predicted Restricted Antigenic Coverages for Spike and Nucleocapsid Proteins Are Associated With Deaths Related to COVID-19
Published in Frontiers in immunology (16-12-2020)“…The world is dealing with one of the worst pandemics ever. SARS-CoV-2 is the etiological agent of COVID-19 that has already spread to more than 200 countries…”
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Dietary Protein Restriction Improves Metabolic Dysfunction in Patients with Metabolic Syndrome in a Randomized, Controlled Trial
Published in Nutrients (28-06-2022)“…Dietary restriction (DR) reduces adiposity and improves metabolism in patients with one or more symptoms of metabolic syndrome. Nonetheless, it remains elusive…”
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4
Distribution of a novel CYP2C haplotype in Native American populations
Published in Frontiers in genetics (21-03-2023)“…The gene, located in the cluster, encodes the major drug metabolism enzyme CYP2C19. This gene is highly polymorphic and no-function ( and * ), reduced function…”
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Single-cell resolution characterization of myeloid-derived cell states with implication in cancer outcome
Published in Nature communications (07-07-2024)“…Tumor-associated myeloid-derived cells (MDCs) significantly impact cancer prognosis and treatment responses due to their remarkable plasticity and tumorigenic…”
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Single Nucleotide Variants as Proxies for HLA-A31:01 in Native American Populations
Published in Frontiers in pharmacology (14-04-2022)“…Carbamazepine triggers dermatologic hypersensitivity reactions, associated with specific human leukocyte antigens (HLAs), especially and Previous efforts to…”
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Functional plasticity shapes neutrophil response to Leishmania major infection in susceptible and resistant strains of mice
Published in PLoS pathogens (08-10-2024)“…Neutrophils rapidly infiltrate sites of infection and possess several microbicidal strategies, such as neutrophil extracellular traps release and phagocytosis…”
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In silico analysis of mutant epitopes in new SARS-CoV-2 lineages suggest global enhanced CD8+ T cell reactivity and also signs of immune response escape
Published in Infection, genetics and evolution (01-04-2022)“…SARS-CoV-2 variants of concern have emerged since the COVID-19 outburst, notably the lineages detected in the UK, South Africa, and Brazil. Their increased…”
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Extracellular vesicle‐mediated crosstalk between melanoma and the immune system: Impact on tumor progression and therapy response
Published in Journal of leukocyte biology (01-10-2020)“…Melanoma is a very lethal tumor type that easily spreads and colonizes regional and distant tissues. Crucial phenotypic changes that favor melanoma metastasis…”
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High infiltration of B cells in tertiary lymphoid structures, TCR oligoclonality, and neoantigens are part of esophageal squamous cell carcinoma microenvironment
Published in Journal of leukocyte biology (01-10-2020)“…Esophageal squamous cell carcinoma (ESCA) exhibits high intratumoral molecular heterogeneity posing a challenge to cancer therapy. Immune checkpoint blockade…”
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Tissue-specific metabolic profile drives iNKT cell function during obesity and liver injury
Published in Cell reports (Cambridge) (31-01-2023)“…Invariant natural killer T (iNKT) cells are a distinct population of lymphocytes characterized by their reactivity to glycolipids presented by CD1d. iNKT cells…”
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Immunological-based approaches for cancer therapy
Published in Clinics (São Paulo, Brazil) (01-01-2018)“…The immunologic landscape of tumors has been continuously unveiled, providing a new look at the interactions between cancer cells and the immune system…”
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SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner
Published in Nature communications (29-09-2022)“…Visceral adiposity is a risk factor for severe COVID-19, and a link between adipose tissue infection and disease progression has been proposed. Here we…”
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14
IL-1β sensitizes mice to atrial fibrillation
Published in Journal of molecular and cellular cardiology (31-12-2022)Get full text
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Connecting multiple microenvironment proteomes uncovers the biology in head and neck cancer
Published in Nature communications (07-11-2022)“…The poor prognosis of head and neck cancer (HNC) is associated with metastasis within the lymph nodes (LNs). Herein, the proteome of 140 multisite samples from…”
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