Search Results - "Pretorius, Pieter J"

Is the role of circulating DNA as a biomarker of cancer being prematurely overrated? by van der Vaart, Maniesh, Pretorius, Pieter J.

“…Circulating DNA is utilized widely as a genetic biomarker in a variety of pathological conditions, mainly in cancerous conditions. Quantification of…”
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A Comparison of the Genotoxic Effects of Gold Nanoparticles Functionalized with Seven Different Ligands in Cultured Human Hepatocellular Carcinoma Cells by Mulder, Danielle, Taute, Cornelius Johannes Francois, van Wyk, Mari, Pretorius, Pieter J

“…Gold nanoparticles (GNPs) have shown great potential in diagnostic and therapeutic applications in diseases, such as cancer. Despite GNP versatility, there is…”
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Using a medium-throughput comet assay to evaluate the global DNA methylation status of single cells by Lewies, Angélique, Van Dyk, Etresia, Wentzel, Johannes F, Pretorius, Pieter J

“…The comet assay is a simple and cost effective technique, commonly used to analyze and quantify DNA damage in individual cells. The versatility of the comet…”
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Assessing the DNA methylation status of single cells with the comet assay by Wentzel, Johannes F., Gouws, Chrisna, Huysamen, Cristal, Dyk, Etresia van, Koekemoer, Gerhard, Pretorius, Pieter J.

“…The comet assay (single cell gel electrophoresis) is a cost-effective, sensitive, and simple technique that is traditionally used for analyzing and quantifying…”
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O6 -methylguanine-DNA methyltransferase (MGMT): Can function explain a suicidal mechanism? by Gouws, Chrisna, Pretorius, Pieter J

“…Abstract Why does O6 -methylguanine-DNA methyltransferase (MGMT), an indispensable DNA repair enzyme, have a mechanism which seems to run counter to its…”
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Point mutation instability (PIN) mutator phenotype as model for true back mutations seen in hereditary tyrosinemia type 1 – a hypothesis by van Dyk, Etresia, Pretorius, Pieter J.

“…Hereditary tyrosinemia type 1 (HT1) is an autosomal recessive disorder affecting fumarylacetoacetate hydrolase (FAH), the last enzyme in the tyrosine…”
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The molecular relationship between deficient UDP-galactose uridyl transferase (GALT) and ceramide galactosyltransferase (CGT) enzyme function: A possible cause for poor long-term prognosis in classic galactosemia by Lebea, Phiyani Justice, Pretorius, Pieter J.

“…Classic galactosemia is an autosomal recessive disorder that is caused by activity deficiency of the UDP-galactose uridyl transferase (GALT). The clinical…”
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In vitro antioxidant, antimutagenic and genoprotective activity of Rosa roxburghii fruit extract by van der Westhuizen, Francois H, van Rensburg, Catharina S. Janse, Rautenbach, George S, Marnewick, Jeanine L, Loots, Du Toit, Huysamen, Cristal, Louw, Roan, Pretorius, Pieter J, Erasmus, Elardus

“…The antioxidant properties of the fruit of the Rosa roxburghii (RR) plant have been associated with several putative health promoting effects. The possible…”
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Mitochondrial DNA replication and OXPHOS gene transcription show varied responsiveness to Rieske protein knockdown in 143B cells by Levanets, Oksana, Reinecke, Fimmie, Louw, Roan, Pretorius, Pieter J., du Plessis, Lissinda H., Nijtmans, Leo, Smeitink, Jan A.M., van der Westhuizen, Francois H.

“…Genetic, biochemical and phenotypic diversity is a hallmark of OXPHOS deficiencies. Among the responses frequently reported for these deficiencies is…”
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Increased Excretion of C4-Carnitine Species after a Therapeutic Acetylsalicylic Acid Dose : Evidence for an Inhibitory Effect on Short-Chain Fatty Acid Metabolism by Jansen van Rensburg, Peet, Mels, Catharina M. C., van der Westhuizen, Francois H., Pretorius, Pieter J., Erasmus, Elardus

“…Acetylsalicylic acid and/or its metabolites are implicated to have various effects on metabolism and, especially, on mitochondrial function. These effects…”
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O 6-methylguanine-DNA methyltransferase (MGMT): Can function explain a suicidal mechanism? by Gouws, Chrisna, Pretorius, Pieter J.

“…Why does O 6-methylguanine-DNA methyltransferase (MGMT), an indispensable DNA repair enzyme, have a mechanism which seems to run counter to its importance?…”
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Carnitine Palmitoyltransferase I Activity Monitoring in Fibroblasts and Leukocytes Using Electrospray Ionization Mass Spectrometry by Nolte, Luzaan, van der Westhuizen, Francois H., Pretorius, Pieter J., Erasmus, Elardus

“…Carnitine palmitoyltransferase I (CPT I) is one of the enzymes associated with normal mitochondrial membrane transport of certain metabolites. The importance…”
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