Search Results - "Prestwood, Tyler"

Systemic Immunity Is Required for Effective Cancer Immunotherapy by Spitzer, Matthew H., Carmi, Yaron, Reticker-Flynn, Nathan E., Kwek, Serena S., Madhireddy, Deepthi, Martins, Maria M., Gherardini, Pier Federico, Prestwood, Tyler R., Chabon, Jonathan, Bendall, Sean C., Fong, Lawrence, Nolan, Garry P., Engleman, Edgar G.

“…Immune responses involve coordination across cell types and tissues. However, studies in cancer immunotherapy have focused heavily on local immune responses in…”
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Enhanced infection of liver sinusoidal endothelial cells in a mouse model of antibody-induced severe dengue disease by Zellweger, Raphaël M, Prestwood, Tyler R, Shresta, Sujan

“…Dengue virus (DENV) causes disease ranging from dengue fever (DF), a self-limited febrile illness, to the potentially lethal dengue hemorrhagic fever and…”
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Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8+ T Cell-Mediated Immunity in Colorectal Cancer by Bhattacharya, Nupur, Yuan, Robert, Prestwood, Tyler R., Penny, Hweixian Leong, DiMaio, Michael A., Reticker-Flynn, Nathan E., Krois, Charles R., Kenkel, Justin A., Pham, Tho D., Carmi, Yaron, Tolentino, Lorna, Choi, Okmi, Hulett, Reyna, Wang, Jinshan, Winer, Daniel A., Napoli, Joseph L., Engleman, Edgar G.

“…Although all-trans-retinoic acid (atRA) is a key regulator of intestinal immunity, its role in colorectal cancer (CRC) is unknown. We found that mice with…”
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Neutrophil-activating therapy for the treatment of cancer by Linde, Ian L., Prestwood, Tyler R., Qiu, Jingtao, Pilarowski, Genay, Linde, Miles H., Zhang, Xiangyue, Shen, Lei, Reticker-Flynn, Nathan E., Chiu, David Kung-Chun, Sheu, Lauren Y., Van Deursen, Simon, Tolentino, Lorna L., Song, Wen-Chao, Engleman, Edgar G.

“…Despite their cytotoxic capacity, neutrophils are often co-opted by cancers to promote immunosuppression, tumor growth, and metastasis. Consequently, these…”
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Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity by Carmi, Yaron, Spitzer, Matthew H., Linde, Ian L., Burt, Bryan M., Prestwood, Tyler R., Perlman, Nicola, Davidson, Matthew G., Kenkel, Justin A., Segal, Ehud, Pusapati, Ganesh V., Bhattacharya, Nupur, Engleman, Edgar G.

“…Naturally occurring tumour-binding IgG antibodies are shown to initiate the rejection of allogeneic tumours, whereby Fc-receptor-mediated uptake of tumour…”
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Roles of inflammation in intrinsic pathophysiology and antipsychotic drug-induced metabolic disturbances of schizophrenia by Prestwood, Tyler R., Asgariroozbehani, Roshanak, Wu, Sally, Agarwal, Sri Mahavir, Logan, Ryan W., Ballon, Jacob S., Hahn, Margaret K., Freyberg, Zachary

“…•Schizophrenia is characterized by intrinsic metabolic and immune dysfunction.•Antipsychotic drugs alter both metabolic and immune function.•Treating…”
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Design of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery by Ofori, Leslie O, Withana, Nimali P, Prestwood, Tyler R, Verdoes, Martijn, Brady, Jennifer J, Winslow, Monte M, Sorger, Jonathan, Bogyo, Matthew

“…There is a need for new molecular-guided contrast agents to enhance surgical procedures such as tumor resection that require a high degree of precision…”
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Gamma Interferon (IFN-γ) Receptor Restricts Systemic Dengue Virus Replication and Prevents Paralysis in IFN-α/β Receptor-Deficient Mice by PRESTWOOD, Tyler R, MORAR, Malika M, ZELLWEGER, Raphaël M, MILLER, Robyn, MAY, Monica M, YAUCH, Lauren E, LADA, Steven M, SHRESTA, Sujan

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CD4+ T cells are not required for the induction of dengue virus-specific CD8+ T cell or antibody responses but contribute to protection after vaccination by Yauch, Lauren E, Prestwood, Tyler R, May, Monica M, Morar, Malika M, Zellweger, Raphaël M, Peters, Bjoern, Sette, Alessandro, Shresta, Sujan

“…The contribution of T cells to the host response to dengue virus (DENV) infection is not well understood. We previously demonstrated a protective role for…”
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A Protective Role for Dengue Virus-Specific CD8+ T Cells by Yauch, Lauren E, Zellweger, Raphael M, Kotturi, Maya F, Qutubuddin, Afrina, Sidney, John, Peters, Bjoern, Prestwood, Tyler R, Sette, Alessandro, Shresta, Sujan

“…Infection with one of the four serotypes of dengue virus (DENV1-4) can result in a range of clinical manifestations in humans, from dengue fever to the more…”
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Enteric Glia Play a Critical Role in Promoting the Development of Colorectal Cancer by Yuan, Robert, Bhattacharya, Nupur, Kenkel, Justin A, Shen, Jeanne, DiMaio, Michael A, Bagchi, Sreya, Prestwood, Tyler R, Habtezion, Aida, Engleman, Edgar G

“…Enteric glia are a distinct population of peripheral glial cells in the enteric nervous system that regulate intestinal homeostasis, epithelial barrier…”
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Human Regulatory Dendritic Cells Develop From Monocytes in Response to Signals From Regulatory and Helper T Cells by Zhang, Xiangyue, Zheng, Pingping, Prestwood, Tyler R, Zhang, Hong, Carmi, Yaron, Tolentino, Lorna L, Wu, Nancy, Choi, Okmi, Winer, Daniel A, Strober, Samuel, Kang, Eun-Suk, Alonso, Michael N, Engleman, Edgar G

“…Dendritic cells (DCs) are powerful antigen presenting cells, derived from bone marrow progenitors (cDCs) and monocytes (moDCs), that can shape the immune…”
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Trafficking and Replication Patterns Reveal Splenic Macrophages as Major Targets of Dengue Virus in Mice by PRESTWOOD, Tyler R, MAY, Monica M, PLUMMER, Emily M, MORAR, Malika M, YAUCH, Lauren E, SHRESTA, Sujan

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A Mouse-Passaged Dengue Virus Strain with Reduced Affinity for Heparan Sulfate Causes Severe Disease in Mice by Establishing Increased Systemic Viral Loads by PRESTWOOD, Tyler R, PRIGOZHIN, Daniil M, SHARAR, Kristin L, ZELLWEGER, Raphaël M, SHRESTA, Sujan

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Cardif-Mediated Signaling Controls the Initial Innate Response to Dengue Virus In Vivo by PERRY, Stuart T, PRESTWOOD, Tyler R, LADA, Steven M, BENEDICT, Chris A, SHRESTA, Sujan

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Tumor-binding antibodies induce potent dendritic cell-mediated tumor immunity by Carmi, Yaron, Prestwood, Tyler, Engleman, Edgar G.

“…The factors that determine the impact of antitumor antibodies on tumor progression are poorly defined. We found that the tumor microenvironment holds the key…”
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T cell help shapes B cell tolerance by Akama-Garren, Elliot H, Yin, Xihui, Prestwood, Tyler R, Ma, Minghe, Utz, Paul J, Carroll, Michael C

“…T cell help is a crucial component of the normal humoral immune response, yet whether it promotes or restrains autoreactive B cell responses remains unclear…”
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Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity by Carmi, Yaron, Prestwood, Tyler R, Spitzer, Matthew H, Linde, Ian L, Chabon, Jonathan, Reticker-Flynn, Nathan E, Bhattacharya, Nupur, Zhang, Hong, Zhang, Xiangyue, Basto, Pamela A, Burt, Bryan M, Alonso, Michael N, Engleman, Edgar G

“…BM-derived DC (BMDC) are powerful antigen-presenting cells. When loaded with immune complexes (IC), consisting of tumor antigens bound to antitumor antibody,…”
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Restoring Retinoic Acid Attenuates Intestinal Inflammation and Tumorigenesis in APCMin/+ Mice by Penny, Hweixian Leong, Prestwood, Tyler R, Bhattacharya, Nupur, Sun, Fionna, Kenkel, Justin A, Davidson, Matthew G, Shen, Lei, Zuniga, Luis A, Seeley, E Scott, Pai, Reetesh, Choi, Okmi, Tolentino, Lorna, Wang, Jinshan, Napoli, Joseph L, Engleman, Edgar G

“…Chronic intestinal inflammation accompanies familial adenomatous polyposis (FAP) and is a major risk factor for colorectal cancer in patients with this…”
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Detection of Intestinal Cancer by Local, Topical Application of a Quenched Fluorescence Probe for Cysteine Cathepsins by Segal, Ehud, Prestwood, Tyler R., van der Linden, Wouter A., Carmi, Yaron, Bhattacharya, Nupur, Withana, Nimali, Verdoes, Martijn, Habtezion, Aida, Engleman, Edgar G., Bogyo, Matthew

“…Early detection of colonic polyps can prevent up to 90% of colorectal cancer deaths. Conventional colonoscopy readily detects the majority of premalignant…”
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