Search Results - "Preston, Kyle"

Targeting mitochondrial fission as a potential therapeutic for abdominal aortic aneurysm by Cooper, Hannah A, Cicalese, Stephanie, Preston, Kyle J, Kawai, Tatsuo, Okuno, Keisuke, Choi, Eric T, Kasahara, Shingo, Uchida, Haruhito A, Otaka, Nozomu, Scalia, Rosario, Rizzo, Victor, Eguchi, Satoru

“…Abstract Aims Angiotensin II (AngII) is a potential contributor to the development of abdominal aortic aneurysm (AAA). In aortic vascular smooth muscle cells…”
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Mitochondrial Fission Mediates Endothelial Inflammation by Forrester, Steven J., Preston, Kyle J., Cooper, Hannah A., Boyer, Michael J., Escoto, Kathleen M., Poltronetti, Anthony J., Elliott, Katherine J., Kuroda, Ryohei, Miyao, Masashi, Sesaki, Hiromi, Akiyama, Tomoko, Kimura, Yayoi, Rizzo, Victor, Scalia, Rosario, Eguchi, Satoru

“…Endothelial inflammation and mitochondrial dysfunction have been implicated in cardiovascular diseases, yet, a unifying mechanism tying them together remains…”
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Caveolin-1 Deletion Prevents Hypertensive Vascular Remodeling Induced by Angiotensin II by Forrester, Steven J, Elliott, Katherine J, Kawai, Tatsuo, Obama, Takashi, Boyer, Michael J, Preston, Kyle J, Yan, Zhen, Eguchi, Satoru, Rizzo, Victor

“…It has been proposed that membrane microdomains, caveolae, in vascular cells are critical for signal transduction and downstream functions induced by…”
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First-principle derivation of gain in high-index-contrast waveguides by Robinson, Jacob T, Preston, Kyle, Painter, Oskar, Lipson, Michal

“…From first principles we develop figures of merit to determine the gain experienced by the guided mode and the lasing threshold for devices based on…”
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Postprandial activation of leukocyte‐endothelium interaction by fatty acids in the visceral adipose tissue microcirculation by Preston, Kyle J., Rom, Inna, Vrakas, Christine, Landesberg, Gavin, Etwebi, Zienab, Muraoka, Sanae, Autieri, Michael, Eguchi, Satoru, Scalia, Rosario

“…High‐fat diet (HFD)‐induced obesity is associated with accumulation of inflammatory cells predominantly in visceral adipose depots [visceral adipose tissue…”
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Mitochondrial fission inhibition protects against hypertension induced by angiotensin II by Preston, Kyle J, Kawai, Tatsuo, Torimoto, Keiichi, Kuroda, Ryohei, Nakayama, Yuki, Akiyama, Tomoko, Kimura, Yayoi, Scalia, Rosario, Autieri, Michael V, Rizzo, Victor, Hashimoto, Tomoki, Osei-Owusu, Patrick, Eguchi, Satoru

“…Mitochondrial dysfunction has been implicated in various types of cardiovascular disease including hypertension. Mitochondrial fission fusion balance is…”
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Vascular ADAM17 (a Disintegrin and Metalloproteinase Domain 17) Is Required for Angiotensin II/β-Aminopropionitrile–Induced Abdominal Aortic Aneurysm by Kawai, Tatsuo, Takayanagi, Takehiko, Forrester, Steven J, Preston, Kyle J, Obama, Takashi, Tsuji, Toshiyuki, Kobayashi, Tomonori, Boyer, Michael J, Cooper, Hannah A, Kwok, Hang Fai, Hashimoto, Tomoki, Scalia, Rosario, Rizzo, Victor, Eguchi, Satoru

“…Angiotensin II (AngII)–activated epidermal growth factor receptor has been implicated in abdominal aortic aneurysm (AAA) development. In vascular smooth muscle…”
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Endothelial cell-derived extracellular vesicles alter vascular smooth muscle cell phenotype through high-mobility group box proteins by Boyer, Michael J., Kimura, Yayoi, Akiyama, Tomoko, Baggett, Ariele Y., Preston, Kyle J., Scalia, Rosario, Eguchi, Satoru, Rizzo, Victor

“…The vascular endothelium and smooth muscle form adjacent cellular layers that comprise part of the vascular wall. Each cell type can regulate the other's…”
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Adipocyte Phenotype Flexibility and Lipid Dysregulation by Preston, Kyle J, Scalia, Rosario G, Autieri, Michael V

“…The prevalence of obesity and associated cardiometabolic diseases continues to rise, despite efforts to improve global health. The adipose tissue is now…”
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Linearized silicon modulator based on a ring assisted Mach Zehnder inteferometer by Cardenas, Jaime, Morton, Paul A, Khurgin, Jacob B, Griffith, Austin, Poitras, Carl B, Preston, Kyle, Lipson, Michal

“…We demonstrate a Linearized Ring Assisted Mach-Zehnder Interferometer (L-RAMZI) modulator in a miniature silicon device. We measure a record high degree of…”
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Deposited silicon high-speed integrated electro-optic modulator by Preston, Kyle, Manipatruni, Sasikanth, Gondarenko, Alexander, Poitras, Carl B, Lipson, Michal

“…We demonstrate a micrometer-scale electro-optic modulator operating at 2.5 Gbps and 10 dB extinction ratio that is fabricated entirely from deposited silicon…”
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High-speed all-optical modulation using polycrystalline silicon microring resonators by Preston, Kyle, Dong, Po, Schmidt, Bradley, Lipson, Michal

“…We experimentally demonstrate on-chip active photonic devices fabricated from deposited polycrystalline silicon, which can be used for monolithic…”
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FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC contractility, and blood pressure by multiple mechanisms by St. Paul, Amanda, Corbett, Cali, Peluzzo, Amanda, Kelemen, Sheri, Okune, Rachael, Haines, Dale S., Preston, Kyle, Eguchi, Satoru, Autieri, Michael V.

“…Appropriate cytoskeletal organization is essential for vascular smooth muscle cell (VSMC) conditions such as hypertension. This study identifies FXR1 as a key…”
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Interleukin-19 decreases leukocyte-endothelial cell interactions by reduction in endothelial cell adhesion molecule mRNA stability by England, Ross N, Preston, Kyle J, Scalia, Rosario, Autieri, Michael V

“…Vascular endothelial cell (EC) inflammation is a key event in the pathogenesis of multiple vascular diseases. We tested the hypothesis that interleukin-19…”
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Integrated GHz silicon photonic interconnect with micrometer-scale modulators and detectors by Chen, Long, Preston, Kyle, Manipatruni, Sasikanth, Lipson, Michal

“…We report an optical link on silicon using micrometer-scale ring-resonator enhanced silicon modulators and waveguide-integrated germanium photodetectors. We…”
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Slot waveguides with polycrystalline silicon for electrical injection by Preston, Kyle, Lipson, Michal

“…We demonstrate horizontal slot waveguides using high-index layers of polycrystalline and single crystalline silicon separated by a 10 nm layer of silicon…”
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Mechanistic Role of the Calcium-Dependent Protease Calpain in the Endothelial Dysfunction Induced by MPO (Myeloperoxidase) by Etwebi, Zienab, Landesberg, Gavin, Preston, Kyle, Eguchi, Satoru, Scalia, Rosario

“…MPO (myeloperoxidase) is a peroxidase enzyme secreted by activated leukocytes that plays a pathogenic role in cardiovascular disease, mainly by initiating…”
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IL‐19 Regulates Atherosclerotic Plaque Progression via Lymphangiogenesis by Peluzzo, Amanda, Preston, Kyle, Leigh, Tani, Kelemen, Sheri, Autieri, Michael

“…Introduction Cardiovascular diseases are the leading cause of deaths globally, representing approximately 31% of deaths per year, 85% of which are due to…”
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Abstract 629: Sensing Nutrient Overload: The Role of the Endothelium by Preston, Kyle, Scalia, Rosario

“…Abstract only Recent data suggest that leukocyte accumulation into visceral fat depots occurs within 72 following high fat feeding. At this early stage,…”
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Abstract P170: Targeting Angiotensin Ii-induced Endoplasmic Reticulum Stress In Vsmcs To Reduce Pathological Vascular Amyloid Burden And Remodeling by Cicalese, Stephanie M, Okuno, Keisuke, Preston, Kyle, Eguchi, Satoru

“…Abstract only Hypertension is a complex disorder and risk factor for cardiovascular disease, ultimately contributing to premature death. The societal burden of…”
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