Search Results - "Pressman, Abe"

The RNA World as a Model System to Study the Origin of Life by Pressman, Abe, Blanco, Celia, Chen, Irene A.

“…Understanding how life arose is a fundamental problem of biology. Much progress has been made by adopting a synthetic and mechanistic perspective on…”
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Mapping a Systematic Ribozyme Fitness Landscape Reveals a Frustrated Evolutionary Network for Self-Aminoacylating RNA by Pressman, Abe D, Liu, Ziwei, Janzen, Evan, Blanco, Celia, Müller, Ulrich F, Joyce, Gerald F, Pascal, Robert, Chen, Irene A

“…Molecular evolution can be conceptualized as a walk over a “fitness landscape”, or the function of fitness (e.g., catalytic activity) over the space of all…”
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Molecular Fitness Landscapes from High-Coverage Sequence Profiling by Blanco, Celia, Janzen, Evan, Pressman, Abe, Saha, Ranajay, Chen, Irene A

“…The function of fitness (or molecular activity) in the space of all possible sequences is known as the fitness landscape. Evolution is a random walk on the…”
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Precision engineering of biological function with large-scale measurements and machine learning by Tack, Drew S, Tonner, Peter D, Pressman, Abe, Olson, Nathan D, Levy, Sasha F, Romantseva, Eugenia F, Alperovich, Nina, Vasilyeva, Olga, Ross, David

“…As synthetic biology expands and accelerates into real-world applications, methods for quantitatively and precisely engineering biological function become…”
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The genotype‐phenotype landscape of an allosteric protein by Tack, Drew S, Tonner, Peter D, Pressman, Abe, Olson, Nathan D, Levy, Sasha F, Romantseva, Eugenia F, Alperovich, Nina, Vasilyeva, Olga, Ross, David

“…Allostery is a fundamental biophysical mechanism that underlies cellular sensing, signaling, and metabolism. Yet a quantitative understanding of allosteric…”
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Analysis of in Vitro Evolution Reveals the Underlying Distribution of Catalytic Activity Among Random Sequences by Pressman, Abe, Moretti, Janina E., Campbell, Gregory W., Müller, Ulrich F., Chen, Irene A.

“…The emergence of catalytic RNA is believed to have been a key event during the origin of life. Understanding how catalytic activity is distributed across…”
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Genomic analysis of methanogenic archaea reveals a shift towards energy conservation by Gilmore, Sean P, Henske, John K, Sexton, Jessica A, Solomon, Kevin V, Seppälä, Susanna, Yoo, Justin I, Huyett, Lauren M, Pressman, Abe, Cogan, James Z, Kivenson, Veronika, Peng, Xuefeng, Tan, YerPeng, Valentine, David L, O'Malley, Michelle A

“…The metabolism of archaeal methanogens drives methane release into the environment and is critical to understanding global carbon cycling. Methanogenesis…”
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Erratum To: The genotype‐phenotype landscape of an allosteric protein by Tack, Drew S, Tonner, Peter D, Pressman, Abe, Olson, Nathan D, Levy, Sasha F, Romantseva, Eugenia F, Alperovich, Nina, Vasilyeva, Olga, Ross, David

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Interpretable modeling of genotype–phenotype landscapes with state-of-the-art predictive power by Tonner, Peter D, Pressman, Abe, Ross, David

“…Large-scale measurements linking genetic background to biological function have driven a need for models that can incorporate these data for reliable…”
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Interpretable modeling of genotype–phenotype landscapes with state-of-the-art predictive power by Tonner, Peter D., Pressman, Abe, Ross, David

“…Large-scale measurements linking genetic background to biological function have driven a need for models that can incorporate these data for reliable…”
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Kinetic sequencing (k-Seq) as a massively parallel assay for ribozyme kinetics: utility and critical parameters by Shen, Yuning, Pressman, Abe, Janzen, Evan, Chen, Irene A

“…Abstract Characterizing genotype-phenotype relationships of biomolecules (e.g. ribozymes) requires accurate ways to measure activity for a large set of…”
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The genotype‐phenotype landscape of an allosteric protein by Tack, Drew S, Tonner, Peter D, Pressman, Abe, Olson, Nathan D, Levy, Sasha F, Romantseva, Eugenia F, Alperovich, Nina, Vasilyeva, Olga, Ross, David

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Analysis of in vitro evolution reveals the underlying distribution of catalytic activity among random sequences by Pressman, Abe, Moretti, Janina E, Campbell, Gregory W, Müller, Ulrich F, Chen, Irene A

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Measuring Biochemical Possibility Spaces in Evolutionary Engineering by Pressman, Abe Daniel

“…At the molecular level, artificial selection—controlling the forces of evolution to improve or design new biochemical functions— makes up one of our strongest…”
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Genomic analysis of methanogenic archaea reveals a shift towards energy conservation by Gilmore, Sean P., Henske, John K., Sexton, Jessica A., Solomon, Kevin V., Seppälä, Susanna, Yoo, Justin I., Huyett, Lauren M., Pressman, Abe, Cogan, James Z., Kivenson, Veronika, Peng, Xuefeng, Tan, YerPeng, Valentine, David L., O’Malley, Michelle A.

“…The metabolism of archaeal methanogens drives methane release into the environment and is critical to understanding global carbon cycling. Methanogenesis…”
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Measurements drive progress in directed evolution for precise engineering of biological systems by Tack, Drew S., Romantseva, Eugenia F., Tonner, Peter D., Pressman, Abe, Rammohan, Jayan, Strychalski, Elizabeth A.

“…Precise engineering of biological systems requires quantitative, high-throughput measurements, exemplified by progress in directed evolution. New approaches…”
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