Search Results - "Press, Nicola E."

Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway by Bruce, Ian, Akhlaq, Mohammed, Bloomfield, Graham C., Budd, Emma, Cox, Brian, Cuenoud, Bernard, Finan, Peter, Gedeck, Peter, Hatto, Julia, Hayler, Judy F., Head, Denise, Keller, Thomas, Kirman, Louise, Leblanc, Catherine, Grand, Darren Le, McCarthy, Clive, O’Connor, Desmond, Owen, Charles, Oza, Mrinalini S., Pilgrim, Gaynor, Press, Nicola E., Sviridenko, Lilya, Whitehead, Lewis

“…Using a parallel synthesis approach to target a non-conserved region of the PI3K catalytic domain a pan-PI3K inhibitor 1 was elaborated to provide alpha, delta…”
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A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential by PRESS, Neil J, TAYLOR, Roger J, HATTO, Julia D. I, KEENAN, Mark, MERCER, Mark K, PRESS, Nicola E, SAHRI, Helene, TUFFNELL, Andrew R, TWEED, Morris, FOZARD, John R, FULLERTON, Joseph D, TRANTER, Pamela, MCCARTHY, Clive, KELLER, Thomas H, BROWN, Lyndon, CHEUNG, Robert, CHRISTIE, Julie, HABERTHUER, Sandra

“…The synthesis and SAR of 5-heterocycle-substituted aminothiazole adenosine receptor antagonists is described. Several compounds show high affinity and…”
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A new orally bioavailable dual adenosine A 2B/A 3 receptor antagonist with therapeutic potential by Press, Neil J., Taylor, Roger J., Fullerton, Joseph D., Tranter, Pamela, McCarthy, Clive, Keller, Thomas H., Brown, Lyndon, Cheung, Robert, Christie, Julie, Haberthuer, Sandra, Hatto, Julia D.I., Keenan, Mark, Mercer, Mark K., Press, Nicola E., Sahri, Helene, Tuffnell, Andrew R., Tweed, Morris, Fozard, John R.

“…The synthesis and SAR of novel aminothiazoles as adenosine receptor antagonists is described, culminating in the synthesis of a potent and orally bioavailable…”
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