Search Results - "Presnell, S. C"

Characterization of a human thyroid microtissue model for testing thyroid disrupting chemicals by Rogers, E, Breathwaite, E K, Nguyen-Jones, T, Anderson, S M, Odanga, J J, Parks, D T, Wolf, K K, Stone, T, Balbuena, P, Chen, J, Presnell, S C, Weaver, J R, LeCluyse, E L

“…Perturbation of thyroid hormone (T ) synthesis is known to cause numerous developmental, metabolic, and cognitive disorders in humans. Due to species…”
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Liver‐Regenerative Transplantation: Regrow and Reset by Collin de l'Hortet, A., Takeishi, K., Guzman‐Lepe, J., Handa, K., Matsubara, K., Fukumitsu, K., Dorko, K., Presnell, S. C., Yagi, H., Soto‐Gutierrez, A.

“…Liver transplantation, either a partial liver from a living or deceased donor or a whole liver from a deceased donor, is the only curative therapy for severe…”
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Liver-Regenerative Transplantation: Regrow and Reset by Collin de l’Hortet, A., Takeishi, K., Guzman-Lepe, J., Handa, K., Matsubara, K., Fukumitsu, K., Dorko, K., Presnell, S.C., Yagi, H., Soto-Gutierrez, A.

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Establishment of a functional HGF/C‐ MET autocrine loop in spontaneous transformants of WB‐F344 rat liver stem‐like cells by Presnell, Sharon C., Hooth, Michelle J., Borchert, Kristen M., Coleman, William B., Grisham, Joe W., Smith, Gary J.

“…A model of spontaneous malignant transformation was used to evaluate the molecular changes that take place in WB‐F344 rat liver epithelial cells during…”
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Androgen receptor regulation of G1 cyclin and cyclin-dependent kinase function in the CWR22 human prostate cancer xenograft by Gregory, C. W, Johnson, R. T., Jr, Presnell, S. C, Mohler, J. L, French, F. S

“…Human prostate cancer is initially dependent on androgens for growth, and androgen‐dependent cells undergo apoptosis after castration. However, a subset of…”
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Spontaneous Neoplastic Transformation of WB-F344 Rat Liver Epithelial Cells by Hooth, Michelle J., Coleman, William B., Presnell, Sharon C., Borchert, Kristen M., Grisham, Joe W., Smith, Gary J.

“…Several studies have shown that cultured rat liver epithelial cells transform spontaneously after chronic maintenance in a confluent state in vitro. In the…”
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Expression of telomerase in normal and malignant rat hepatic epithelia by GOLUBOVSKAYA, V. M, PRESNELL, S. C, HOOTH, M. J, SMITH, G. J, KAUFMANN, W. K

“…Telomerase is a ribonucleoprotein that synthesizes telomeric DNA repeats onto the ends of chromosomes. More than 85% of human cancers express telomerase…”
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Genomic fluidity is a necessary event preceding the acquisition of tumorigenicity during spontaneous neoplastic transformation of WB‐F344 rat liver epithelial cells by Hooth, Michelle J., Vincent, Jack L., Coleman, William B., Presnell, Sharon C., Grisham, Joe W., Smith, Gary J.

“…The genomic evolution of a cohort of WB‐F344 rat liver epithelial cell lineages undergoing spontaneous neoplastic transformation was followed to define the…”
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Induction of rat WT1 gene expression correlates with human chromosome 11p11.2-p12-mediated suppression of tumorigenicity in rat liver epithelial tumor cell lines by Coleman, W B, Ricketts, S L, Borchert, K M, Presnell, S C, Esch, G L, McCullough, K D, Weissman, B E, Smith, G J, Grisham, J W

“…We have previously identified and mapped a locus within human chromosome 11p11.2-p12 that suppresses the tumorigenic potential of some rat liver tumor cell…”
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Isolation and partial characterization of an epithelial cell line (RPE-F344) from the regenerating prostate of a normal adult male rat by Presnell, S C, Glover, W J, Borchert, K M, Gregory, C W, Mohler, J L, Smith, G J

“…Normal prostate epithelial cells are difficult to propagate in vitro without experimental immortalization. The goal of this study was to isolate and…”
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Establishment of Short-Term Primary Human Prostate Xenografts for the Study of Prostate Biology and Cancer by Presnell, Sharon C., Werdin, Eric S., Maygarden, Susan, Mohler, James L., Smith, Gary J.

“…Human tissue xenograft models are currently the only tool for conducting in vivo analyses of intact human tissue. The goal of the present study was to develop…”
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Isolation and characterization of propagable cell lines (HUNC) from the androgen-sensitive Dunning R3327H rat prostatic adenocarcinoma by PRESNELL, S. C, BORCHERT, K. M, GLOVER, W. J, GREGORY, C. W, MOHLER, J. L, SMITH, G. J

“…The Dunning H rat prostate tumor (R3327H) is a widely used experimental model of human prostatic adenocarcinoma (CaP). The Dunning H tumor has been…”
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Plasticity of the hepatocyte phenotype in vitro: complex phenotypic transitions in proliferating hepatocyte cultures suggest bipotent differentiation capacity of mature hepatocytes by Coleman, WB, Presnell, SC

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Aberrant cell cycle checkpoint function in transformed hepatocytes and WB-F344 hepatic epithelial stem-like cells by Kaufmann, William K., Behe, Cynthia I., Golubovskaya, Vita M., Byrd, Laura L., Albright, Craig D., Borchet, Kristen M., Presnell, Sharon C., Coleman, William B., Grisham, Joe W., Smith, Gary J.

“…Cell cycle checkpoints are barriers to carcinogenesis as they function to maintain genomic integrity. Attenuation or ablation of checkpoint function may…”
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Telomere shortening, telomerase expression, and chromosome instability in rat hepatic epithelial stem-like cells by Golubovskaya, Vita M., Filatov, Leonid V., Behe, Cynthia I., Presnell, Sharon C., Hooth, Michelle J., Smith, Gary J., Kaufmann, William K.

“…Telomeres, which are specialized structures consisting of T2AG3 repeats and proteins at the ends of chromosomes, may be essential for genomic stability. To…”
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Investigation of the cooperative effects of transforming growth factor alpha and c-myc overexpression in rat liver epithelial cells by Presnell, S C, Thompson, M T, Strom, S C

“…Overexpression of both transforming growth factor (TGF)-alpha and c-myc is consistently reported in hepatic tumors. We transfected rat liver epithelial cells…”
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Isolation, characterization, and expansion methods for defined primary renal cell populations from rodent, canine, and human normal and diseased kidneys by Presnell, Sharon C, Bruce, Andrew T, Wallace, Shay M, Choudhury, Sumana, Genheimer, Christopher W, Cox, Bryan, Guthrie, Kelly, Werdin, Eric S, Tatsumi-Ficht, Patricia, Ilagan, Roger M, Kelley, Russell W, Rivera, Elias A, Ludlow, John W, Wagner, Belinda J, Jayo, Manuel J, Bertram, Timothy A

“…Chronic kidney disease (CKD) is a global health problem; the growing gap between the number of patients awaiting transplant and organs actually transplanted…”
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Failure to achieve gene conversion with chimeric circular oligonucleotides: potentially misleading PCR artifacts observed by Zhang, Z, Eriksson, M, Falk, G, Graff, C, Presnell, S C, Read, M S, Nichols, T C, Blombäck, M, Anvret, M

“…Recently, a novel strategy for nucleotide exchange of target DNA using chimeric RNA/DNA oligonucleotides (CO) was reported. The CO can easily be transfected…”
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Stem cells in adult tissues by Presnell, Sharon C, Petersen, Bryon, Heidaran, Mohammad

“…In recent years the concept of a stem cell has evolved to encompass the hypotheses that stem cells exist within many adult tissues, and that a common…”
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Plasticity of the hepatocyte phenotype in vitro: Complex phenotypic transitions in proliferating hepatocyte cultures suggest bipotent differentiation capacity of mature hepatocytes by Coleman, W B, Presnell, S C

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