Search Results - "Prescott, Natalie J."

Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease by Lee, James C, Biasci, Daniele, Roberts, Rebecca, Gearry, Richard B, Mansfield, John C, Ahmad, Tariq, Prescott, Natalie J, Satsangi, Jack, Wilson, David C, Jostins, Luke, Anderson, Carl A, Traherne, James A, Lyons, Paul A, Parkes, Miles, Smith, Kenneth G C

“…James Lee, Kenneth Smith and colleagues report a within-cases genome-wide association analysis for Crohn's disease to identify genetic loci specifically…”
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A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1 by Hampe, Jochen, Schreiber, Stefan, Franke, Andre, Rosenstiel, Philip, Till, Andreas, Teuber, Markus, Huse, Klaus, Albrecht, Mario, Mayr, Gabriele, De La Vega, Francisco M, Briggs, Jason, Günther, Simone, Prescott, Natalie J, Onnie, Clive M, Häsler, Robert, Sipos, Bence, Fölsch, Ulrich R, Lengauer, Thomas, Platzer, Matthias, Mathew, Christopher G, Krawczak, Michael

“…We performed a genome-wide association study of 19,779 nonsynonymous SNPs in 735 individuals with Crohn disease and 368 controls. A total of 7,159 of these…”
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Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis by CAPON, Francesca, DI MEGLIO, Paola, LANCHBURY, Jerry, BARKER, Jonathan N, TREMBATH, Richard C, NESTLE, Frank O, SZAUB, Joanna, PRESCOTT, Natalie J, DUNSTER, Christina, BAUMBER, Laura, TIMMS, Kirsten, GUTIN, Alexander, ABKEVIC, Victor, BURDEN, A. David

“…Psoriasis is an inflammatory skin disorder that is inherited as a multifactorial trait. Genetic analyses have repeatedly identified a primary disease…”
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Systematic association mapping identifies NELL1 as a novel IBD disease gene by Franke, Andre, Hampe, Jochen, Rosenstiel, Philip, Becker, Christian, Wagner, Florian, Häsler, Robert, Little, Randall D, Huse, Klaus, Ruether, Andreas, Balschun, Tobias, Wittig, Michael, Elsharawy, Abdou, Mayr, Gabriele, Albrecht, Mario, Prescott, Natalie J, Onnie, Clive M, Fournier, Hélène, Keith, Tim, Radelof, Uwe, Platzer, Matthias, Mathew, Christopher G, Stoll, Monika, Krawczak, Michael, Nürnberg, Peter, Schreiber, Stefan

“…Crohn disease (CD), a sub-entity of inflammatory bowel disease (IBD), is a complex polygenic disorder. Although recent studies have successfully identified…”
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Exome array analysis of adverse reactions to fluoropyrimidine-based therapy for gastrointestinal cancer by Traylor, Matthew, Walker, Jemma L, Corrigan, Adele A, Hernandez, Monica A, Newhouse, Stephen J, Folarin, Amos A, Patel, Hamel, Ross, Paul J, Sanderson, Jeremy D, Spicer, James, Prescott, Natalie J, Mathew, Christopher G, Marinaki, Anthony M, Lewis, Cathryn M

“…Fluoropyrimidines, including 5-fluororacil (5FU) and its pro-drug Capecitabine, are the common treatment for colorectal, breast, neck and head cancers-either…”
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Association of a deletion of GSTT2B with an altered risk of oesophageal squamous cell carcinoma in a South African population: a case-control study by Matejcic, Marco, Li, DongPing, Prescott, Natalie J, Lewis, Cathryn M, Mathew, Christopher G, Parker, M Iqbal

“…Polymorphisms in the Glutathione S-transferase genes are associated with altered risks in many cancers, but their role in oesophageal cancer is unclear…”
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Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease by de Lange, Katrina M, Moutsianas, Loukas, Lee, James C, Lamb, Christopher A, Luo, Yang, Kennedy, Nicholas A, Jostins, Luke, Rice, Daniel L, Gutierrez-Achury, Javier, Ji, Sun-Gou, Heap, Graham, Nimmo, Elaine R, Edwards, Cathryn, Henderson, Paul, Mowat, Craig, Sanderson, Jeremy, Satsangi, Jack, Simmons, Alison, Wilson, David C, Tremelling, Mark, Hart, Ailsa, Mathew, Christopher G, Newman, William G, Parkes, Miles, Lees, Charlie W, Uhlig, Holm, Hawkey, Chris, Prescott, Natalie J, Ahmad, Tariq, Mansfield, John C, Anderson, Carl A, Barrett, Jeffrey C

“…Jeffrey Barrett, Carl Anderson and colleagues report the results of a large genome-wide association study of inflammatory bowel disease. They identify 25 new…”
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Novel isoforms of the CARD8 (TUCAN) gene evade a nonsense mutation by Bagnall, Richard D, Roberts, Roland G, Mirza, Muddassar M, Torigoe, Toshihiko, Prescott, Natalie J, Mathew, Christopher G

“…CARD8 (TUCAN) is implicated in the regulation of apoptosis and inflammation, and is a positional and functional candidate gene for inflammatory bowel disease…”
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Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease by Dart, Robin J, Zlatareva, Iva, Vantourout, Pierre, Theodoridis, Efstathios, Amar, Ariella, Kannambath, Shichina, East, Philip, Recaldin, Timothy, Mansfield, John C, Lamb, Christopher A, Parkes, Miles, Irving, Peter M, Prescott, Natalie J, Hayday, Adrian C

“…Murine intraepithelial γδ T cells include distinct tissue-protective cells selected by epithelial butyrophilin-like (BTNL) heteromers. To determine whether…”
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Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn's disease and their unaffected siblings by Hedin, Charlotte R, McCarthy, Neil E, Louis, Petra, Farquharson, Freda M, McCartney, Sara, Taylor, Kirstin, Prescott, Natalie J, Murrells, Trevor, Stagg, Andrew J, Whelan, Kevin, Lindsay, James O

“…Crohn's disease (CD) is associated with intestinal dysbiosis, altered blood T cell populations, elevated faecal calprotectin (FC) and increased intestinal…”
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Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7 by Luo, Yang, de Lange, Katrina M, Jostins, Luke, Moutsianas, Loukas, Randall, Joshua, Kennedy, Nicholas A, Lamb, Christopher A, McCarthy, Shane, Ahmad, Tariq, Edwards, Cathryn, Serra, Eva Goncalves, Hart, Ailsa, Hawkey, Chris, Mansfield, John C, Mowat, Craig, Newman, William G, Nichols, Sam, Pollard, Martin, Satsangi, Jack, Simmons, Alison, Tremelling, Mark, Uhlig, Holm, Wilson, David C, Lee, James C, Prescott, Natalie J, Lees, Charlie W, Mathew, Christopher G, Parkes, Miles, Barrett, Jeffrey C, Anderson, Carl A

“…Carl Anderson, Jeffrey Barrett and colleagues use whole-genome sequencing and imputation to explore the genetic architecture of inflammatory bowel disease…”
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Genetic and Inflammatory Biomarkers Classify Small Intestine Inflammation in Asymptomatic First-degree Relatives of Patients With Crohn’s Disease by Taylor, Kirstin M., Hanscombe, Ken B., Prescott, Natalie J., Iniesta, Raquel, Traylor, Matthew, Taylor, Nicola S., Fong, Steven, Powell, Nicholas, Irving, Peter M., Anderson, Simon H., Mathew, Christopher G., Lewis, Cathryn M., Sanderson, Jeremy D.

“…Relatives of individuals with Crohn's disease (CD) carry CD-associated genetic variants and are often exposed to environmental factors that increase their risk…”
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Streptococcus Salivarius: A Potential Salivary Biomarker for Orofacial Granulomatosis and Crohn's Disease? by Goel, Rishi M, Prosdocimi, Erica M, Amar, Ariella, Omar, Yasmin, Escudier, Michael P, Sanderson, Jeremy D, Wade, William G, Prescott, Natalie J

“…Orofacial granulomatosis (OFG) is a rare disease characterised by chronic, noncaseating, granulomatous inflammation primarily affecting the oral cavity…”
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Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility by Parkes, Miles, Barrett, Jeffrey C, Prescott, Natalie J, Tremelling, Mark, Anderson, Carl A, Fisher, Sheila A, Roberts, Roland G, Nimmo, Elaine R, Cummings, Fraser R, Soars, Dianne, Drummond, Hazel, Lees, Charlie W, Khawaja, Saud A, Bagnall, Richard, Burke, Denis A, Todhunter, Catherine E, Ahmad, Tariq, Onnie, Clive M, McArdle, Wendy, Strachan, David, Bethel, Graeme, Bryan, Claire, Lewis, Cathryn M, Deloukas, Panos, Forbes, Alastair, Sanderson, Jeremy, Jewell, Derek P, Satsangi, Jack, Mansfield, John C, Cardon, Lon, Mathew, Christopher G

“…A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel…”
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Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota by Benjamin, Jane L., Hedin, Charlotte R.H., Koutsoumpas, Andreas, Ng, Siew C., McCarthy, Neil E., Prescott, Natalie J., Pessoa‐Lopes, Pedro, Mathew, Christopher G., Sanderson, Jeremy, Hart, Ailsa L., Kamm, Michael A., Knight, Stella C., Forbes, Alastair, Stagg, Andrew J., Lindsay, James O., Whelan, Kevin

“…Background: Patients with Crohn's disease (CD) have an intestinal dysbiosis with components of the microbiota exerting differential immune effects. Smoking is…”
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Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease by Ouwehand, Willem, Keniry, Andrew, Fisher, Sheila A, Jewell, Derek P, Anderson, Carl A, Prescott, Natalie J, Deloukas, Panos, Blaszczyk, Katarzyna, Mansfield, John C, Mathew, Christopher G, Watkins, Nick, Drummond, Hazel, Cummings, Fraser R, Forbes, Alastair, Barrett, Jeffrey C, Ravindrarajah, Radhi, Sanderson, Jeremy, Inouye, Mike, Hunt, Sarah, Nimmo, Elaine R, Johnson, Christopher, Bumpstead, Suzannah, Hanson, Catherine E, Lobo, Alan, Massey, Dunecan, Cardon, Lon, Ewels, Philip, Satsangi, Jack, Tremelling, Mark, Gwilliam, Rhian, Carter, Martyn, Berzuini, Carlo, Lees, Charlie W, Onnie, Clive M, Parkes, Miles, Lewis, Cathryn M

“…We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several…”
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Association of genetic variants in CHEK2 with oesophageal squamous cell carcinoma in the South African Black population by Chen, Wenlong C, Bye, Hannah, Matejcic, Marco, Amar, Ariella, Govender, Dhiren, Khew, Yee Wen, Beynon, Victoria, Kerr, Robyn, Singh, Elvira, Prescott, Natalie J, Lewis, Cathryn M, Babb de Villiers, Chantal, Parker, M Iqbal, Mathew, Christopher G

“…Oesophageal squamous cell carcinoma (OSCC) has a high incidence in southern Africa and a poor prognosis. Limited information is available on the contribution…”
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Measurement methods and accuracy in copy number variation: failure to replicate associations of beta-defensin copy number with Crohn's disease by Aldhous, Marian C., Abu Bakar, Suhaili, Prescott, Natalie J., Palla, Raquel, Soo, Kimberley, Mansfield, John C., Mathew, Christopher G., Satsangi, Jack, Armour, John A.L.

“…The copy number variation in beta-defensin genes on human chromosome 8 has been proposed to underlie susceptibility to inflammatory disorders, but presents…”
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Investigation of Crohn's Disease Risk Loci in Ulcerative Colitis Further Defines Their Molecular Relationship by Anderson, Carl A, Massey, Dunecan C.O, Barrett, Jeffrey C, Prescott, Natalie J, Tremelling, Mark, Fisher, Sheila A, Gwilliam, Rhian, Jacob, Jemima, Nimmo, Elaine R, Drummond, Hazel, Lees, Charlie W, Onnie, Clive M, Hanson, Catherine, Blaszczyk, Katarzyna, Ravindrarajah, Radhi, Hunt, Sarah, Varma, Dhiraj, Hammond, Naomi, Lewis, Gregory, Attlesey, Heather, Watkins, Nick, Ouwehand, Willem, Strachan, David, McArdle, Wendy, Lewis, Cathryn M, Lobo, Alan, Sanderson, Jeremy, Jewell, Derek P, Deloukas, Panos, Mansfield, John C, Mathew, Christopher G, Satsangi, Jack, Parkes, Miles

“…Background & Aims Identifying shared and disease-specific susceptibility loci for Crohn's disease (CD) and ulcerative colitis (UC) would help define the…”
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IL23R Variation Determines Susceptibility But Not Disease Phenotype in Inflammatory Bowel Disease by Tremelling, Mark, Cummings, Fraser, Fisher, Sheila A, Mansfield, John, Gwilliam, Rhian, Keniry, Andrew, Nimmo, Elaine R, Drummond, Hazel, Onnie, Clive M, Prescott, Natalie J, Sanderson, Jeremy, Bredin, Francesca, Berzuini, Carlo, Forbes, Alastair, Lewis, Cathryn M, Cardon, Lon, Deloukas, Panos, Jewell, Derek, Mathew, Christopher G, Parkes, Miles, Satsangi, Jack

“…Background & Aims: Identification of inflammatory bowel disease (IBD) susceptibility genes is key to understanding pathogenic mechanisms. Recently, the North…”
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