Search Results - "Premeaux, Thomas A"

The latent HIV reservoir: current advances in genetic sequencing approaches by Moar, Preeti, Premeaux, Thomas A, Atkins, Andrew, Ndhlovu, Lishomwa C

“…Multiple cellular HIV reservoirs in diverse anatomical sites can undergo clonal expansion and persist for years despite suppressive antiretroviral therapy,…”
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Plasma inflammatory biomarkers link to diffusion tensor imaging metrics in virally suppressed HIV-infected individuals by Chang, Kevin, Premeaux, Thomas A., Cobigo, Yann, Milanini, Benedetta, Hellmuth, Joanna, Rubin, Leah H., Javandel, Shireen, Allen, Isabel, Ndhlovu, Lishomwa C., Paul, Robert, Valcour, Victor

“…OBJECTIVE:Inflammation may contribute to brain white matter health in people living with HIV who report cognitive symptoms despite adherence to combination…”
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Alterations in circulating immunoregulatory proteins discriminate poor CD4 T lymphocyte trajectories in people with HIV on suppressive antiretroviral therapy by Moar, Preeti, Bowler, Scott, Landay, Alan L, Gianella, Sara, Ndhlovu, Lishomwa C, Premeaux, Thomas A

“…Despite the success in the management of HIV with antiretroviral therapy (ART), people with HIV (PWH) have a heightened state of immune activation and…”
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Galectin-9 protects humanized-ACE2 immunocompetent mice from SARS-CoV-2 infection by Yeung, Stephen T., Premeaux, Thomas A., Du, Li, Niki, Toshiro, Pillai, Satish K., Khanna, Kamal M., Ndhlovu, Lishomwa C.

“…SARS-CoV-2 remains a global health crisis even with effective vaccines and the availability of FDA approved therapies. Efforts to understand the complex…”
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Multiplex Analysis of Cytokines and Chemokines in Persons Aging With or Without HIV by Kroll, Kyle W, Woolley, Griffin, Terry, Karen, Premeaux, Thomas A, Shikuma, Cecilia M, Corley, Michael J, Bowler, Scott, Ndhlovu, Lishomwa C, Reeves, R Keith

“…People with HIV (PWH) on combination antiretroviral therapy (cART) are living longer lives due to modern cART advances and increased routine medical care. The…”
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Emerging Insights on Caspases in COVID-19 Pathogenesis, Sequelae, and Directed Therapies by Premeaux, Thomas A, Yeung, Stephen T, Bukhari, Zaheer, Bowler, Scott, Alpan, Oral, Gupta, Raavi, Ndhlovu, Lishomwa C

“…Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a significant global health emergency…”
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Dendritic Cells Pulsed with HAM/TSP Exosomes Sensitize CD4 T Cells to Enhance HTLV-1 Infection, Induce Helper T-Cell Polarization, and Decrease Cytotoxic T-Cell Response by Joseph, Julie, Premeaux, Thomas A, Tandon, Ritesh, Murphy, Edward L, Bruhn, Roberta, Nicot, Christophe, Herrera, Bobby Brooke, Lemenze, Alexander, Alatrash, Reem, Baffour Tonto, Prince, Ndhlovu, Lishomwa C, Jain, Pooja

“…HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive demyelinating disease of the spinal cord due to chronic inflammation…”
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Next-Generation Human Cerebral Organoids as Powerful Tools To Advance NeuroHIV Research by Premeaux, Thomas A, Mediouni, Sonia, Leda, Ana, Furler, Robert L, Valente, Susana T, Fine, Howard A, Nixon, Douglas F, Ndhlovu, Lishomwa C

“…Long-term effective use of antiretroviral therapy (ART) among people with HIV (PWH) has significantly reduced the burden of disease, yet a cure for HIV has not…”
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Galectin-9 Mediates HIV Transcription by Inducing TCR-Dependent ERK Signaling by Colomb, Florent, Giron, Leila B, Premeaux, Thomas A, Mitchell, Brooks I, Niki, Toshiro, Papasavvas, Emmanouil, Montaner, Luis J, Ndhlovu, Lishomwa C, Abdel-Mohsen, Mohamed

“…Endogenous plasma levels of the immunomodulatory carbohydrate-binding protein galectin-9 (Gal-9) are elevated during HIV infection and remain elevated after…”
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Health Disparities in COVID-19: Addressing the Role of Social Determinants of Health in Immune System Dysfunction to Turn the Tide by Baumer, Yvonne, Farmer, Nicole, Premeaux, Thomas A, Wallen, Gwenyth R, Powell-Wiley, Tiffany M

“…It is evident that health disparities exist during the COVID-19 pandemic, a pandemic caused by the novel coronavirus SARS-CoV-2. Underlying reasons for…”
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Associations Between Plasma Immunomodulatory and Inflammatory Mediators With VACS Index Scores Among Older HIV-Infected Adults on Antiretroviral Therapy by Premeaux, Thomas A, Javandel, Shireen, Hosaka, Kalei R J, Greene, Meredith, Therrien, Nicholas, Allen, Isabel E, Corley, Michael J, Valcour, Victor G, Ndhlovu, Lishomwa C

“…The prevalence of age-related comorbidities is increased in people living with HIV, even in those well-controlled on combination antiretroviral therapy (ART)…”
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Machine learning models based on fluid immunoproteins that predict non-AIDS adverse events in people with HIV by Premeaux, Thomas A., Bowler, Scott, Friday, Courtney M., Moser, Carlee B., Hoenigl, Martin, Lederman, Michael M., Landay, Alan L., Gianella, Sara, Ndhlovu, Lishomwa C.

“…Despite the success of antiretroviral therapy (ART), individuals with HIV remain at risk for experiencing non-AIDS adverse events (NAEs), including…”
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Hiding in plain sight - platelets, the silent carriers of HIV-1 by Baumer, Yvonne, Weatherby, Tina M, Mitchell, Brooks I, SahBandar, Ivo N, Premeaux, Thomas A, Michelle L, D'Antoni, Gutierrez-Huerta, Cristhian A, Powell-Wiley, Tiffany M, Brown, Timothy R, Boisvert, William A, Shikuma, Cecilia M, Ndhlovu, Lishomwa C

“…There are approximately 38 million people globally living with Human immunodeficiency virus 1 (HIV-1) and given the tremendous success of combination…”
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Targeting the C-terminus of galectin-9 induces mesothelioma apoptosis and M2 macrophage depletion by Bertino, Pietro, Premeaux, Thomas A., Fujita, Tsuyoshi, Haun, Brien K., Marciel, Michael P., Hoffmann, Fukun W., Garcia, Alan, Yiang, Haining, Pastorino, Sandra, Carbone, Michele, Niki, Toshiro, Berestecky, John, Hoffmann, Peter R., Ndhlovu, Lishomwa C.

“…Galectin-9 has emerged as a promising biological target for cancer immunotherapy due to its role as a regulator of macrophage and T-cell differentiation. In…”
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Retroviral b‐Zip protein (HBZ) contributes to the release of soluble and exosomal immune checkpoint molecules in the context of neuroinflammation by Joseph, Julie, Premeaux, Thomas A., Pinto, Daniel O., Rao, Abhishek, Guha, Shrobona, Panfil, Amanda R., Carey, Alison J., Ndhlovu, Lishomwa C., Bergmann‐Leitner, Elke S., Jain, Pooja

“…HTLV‐I‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic, progressive, neuroinflammatory demyelinating condition of the spinal cord. We…”
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Multi-antigen Vaccination With Simultaneous Engagement of the OX40 Receptor Delays Malignant Mesothelioma Growth and Increases Survival in Animal Models by Hoffmann, Peter R, Hoffmann, Fukun W, Premeaux, Thomas A, Fujita, Tsuyoshi, Soprana, Elisa, Panigada, Maddalena, Chew, Glen M, Richard, Guilhem, Hindocha, Pooja, Menor, Mark, Khadka, Vedbar S, Deng, Youping, Moise, Lenny, Ndhlovu, Lishomwa C, Siccardi, Antonio, Weinberg, Andrew D, De Groot, Anne S, Bertino, Pietro

“…Malignant Mesothelioma (MM) is a rare and highly aggressive cancer that develops from mesothelial cells lining the pleura and other internal cavities, and is…”
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Neurocognitive Trajectories After 72 Weeks of First-Line Anti-retroviral Therapy in Vietnamese Adults With HIV-HCV Co-infection by Paul, Robert H, Shikuma, Cecilia M, Chau, Nguyen Van Vinh, Ndhlovu, Lishomwa C, Thanh, Nguyen Tat, Belden, Andrew C, Chow, Dominic C, Chew, Glen M, Premeaux, Thomas A, Ly, Vo Trieu, McBride, Joseph A D, Bolzenius, Jacob D, Le, Thuy

“…Long-term neurocognitive outcomes following first-line suppressive anti-retroviral therapy (ART) remain uncertain for individuals with HIV and hepatitis C…”
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Lower Interferon Regulatory Factor-8 Expression in Peripheral Myeloid Cells Tracks With Adverse Central Nervous System Outcomes in Treated HIV Infection by D'Antoni, Michelle L, Kallianpur, Kalpana J, Premeaux, Thomas A, Corley, Michael J, Fujita, Tsuyoshi, Laws, Elizabeth I, Ogata-Arakaki, Debra, Chow, Dominic C, Khadka, Vedbar S, Shikuma, Cecilia M, Ndhlovu, Lishomwa C

“…Cognitive dysfunction persists in 30-50% of chronically HIV-infected individuals despite combination antiretroviral therapy (ART). Although monocytes are…”
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Genome‐wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID‐19 by Corley, Michael J., Pang, Alina P.S., Dody, Kush, Mudd, Philip A., Patterson, Bruce K., Seethamraju, Harish, Bram, Yaron, Peluso, Michael J., Torres, Leonel, Iyer, Nikita S., Premeaux, Thomas A., Yeung, Stephen T., Chandar, Vasuretha, Borczuk, Alain, Schwartz, Robert E., Henrich, Timothy J., Deeks, Steven G., Sacha, Jonah B., Ndhlovu, Lishomwa C.

“…The global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a highly pathogenic RNA virus causing coronavirus disease…”
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Decrypting biological hallmarks of aging in people with HIV by Premeaux, Thomas A., Ndhlovu, Lishomwa C.

“…HIV infection adds further complexity to the heterogenous process of aging. In this focused review, we examine and discuss recent advances to better elucidate…”
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