Search Results - "Prell, Rodney A."

An anti-CD3/anti–CLL-1 bispecific antibody for the treatment of acute myeloid leukemia by Leong, Steven R., Sukumaran, Siddharth, Hristopoulos, Maria, Totpal, Klara, Stainton, Shannon, Lu, Elizabeth, Wong, Alfred, Tam, Lucinda, Newman, Robert, Vuillemenot, Brian R., Ellerman, Diego, Gu, Chen, Mathieu, Mary, Dennis, Mark S., Nguyen, Allen, Zheng, Bing, Zhang, Crystal, Lee, Genee, Chu, Yu-Waye, Prell, Rodney A., Lin, Kedan, Laing, Steven T., Polson, Andrew G.

“…Acute myeloid leukemia (AML) is a major unmet medical need. Most patients have poor long-term survival, and treatment has not significantly changed in 40…”
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A Two-in-One Antibody against HER3 and EGFR Has Superior Inhibitory Activity Compared with Monospecific Antibodies by Schaefer, Gabriele, Haber, Lauric, Crocker, Lisa M., Shia, Steven, Shao, Lily, Dowbenko, Donald, Totpal, Klara, Wong, Anne, Lee, Chingwei V., Stawicki, Scott, Clark, Robyn, Fields, Carter, Lewis Phillips, Gail D., Prell, Rodney A., Danilenko, Dimitry M., Franke, Yvonne, Stephan, Jean-Philippe, Hwang, Jiyoung, Wu, Yan, Bostrom, Jenny, Sliwkowski, Mark X., Fuh, Germaine, Eigenbrot, Charles

“…Extensive crosstalk among ErbB/HER receptors suggests that blocking signaling from more than one family member may be essential to effectively treat cancer and…”
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Placental and Fetal Effects of Onartuzumab, a Met/HGF Signaling Antagonist, When Administered to Pregnant Cynomolgus Monkeys by Prell, Rodney A, Dybdal, Noel, Arima, Akihiro, Chihaya, Yutaka, Nijem, Ihsan, Halpern, Wendy

“…Onartuzumab is an engineered single arm, monovalent monoclonal antibody that targets the MET receptor and prevents hepatocyte growth factor (HGF) signaling…”
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Activation of Immature Hepatic NK Cells As Immunotherapy for Liver Metastatic Disease by Bahjat, Keith S, Prell, Rodney A, Allen, Heather E, Liu, Weiqun, Lemmens, Edward E, Leong, Meredith L, Portnoy, Daniel A, Dubensky, Thomas W., Jr, Brockstedt, Dirk G, Giedlin, Martin A

“…NK cells can identify and eliminate emerging tumors due to altered expression of activating and inhibitory ligands on aberrant cells, a process that is greatly…”
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The generation of T cell memory: a review describing the molecular and cellular events following OX40 (CD134) engagement by Weinberg, Andrew D., Evans, Dean E., Thalhofer, Colin, Shi, Tom, Prell, Rodney A.

“…OX40 (CD134), a membrane‐bound member of the tumor necrosis factor‐receptor superfamily, is expressed primarily on activated CD4+ T cells. Following engagement…”
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In Vivo Assessment of Antibody-Dependent Enhancement of Influenza B Infection by Rao, Gautham K, Prell, Rodney A, Laing, Steven T, Burleson, Stefanie C M, Nguyen, Allen, McBride, Jacqueline M, Zhang, Crystal, Sheinson, Daniel, Halpern, Wendy G

“…Abstract A theoretical safety concern proposed in the influenza literature is that therapeutic antiviral antibodies could have the potential for…”
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Perspective on a Modified Developmental and Reproductive Toxicity Testing Strategy for Cancer Immunotherapy by Prell, Rodney A., Halpern, Wendy G., Rao, Gautham K.

“…The intent of cancer immunotherapy (CIT) is to generate and enhance T-cell responses against tumors. The tumor microenvironment establishes several inhibitory…”
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Danger and OX40 Receptor Signaling Synergize to Enhance Memory T Cell Survival by Inhibiting Peripheral Deletion by Maxwell, Joseph R, Weinberg, Andrew, Prell, Rodney A, Vella, Anthony T

“…This report defines a cell surface receptor (OX40) expressed on effector CD4 T cells, which when engaged in conjunction with a danger signal, rescues…”
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OX40-Mediated Memory T Cell Generation Is TNF Receptor-Associated Factor 2 Dependent by Prell, Rodney A, Evans, Dean E, Thalhofer, Colin, Shi, Tom, Funatake, Castle, Weinberg, Andrew D

“…Tumor necrosis factor receptor-associated factor 2 (TRAF2), an adapter protein that associates with the cytoplasmic tail of OX40, may play a critical role in…”
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The anti-tumor efficacy of a GM-CSF-secreting tumor cell vaccine is not inhibited by docetaxel administration by PRELL, Rodney A, GEARIN, Lisa, SIMMONS, Andrew, VANROEY, Melinda, JOOSS, Karin

“…Docetaxel has demonstrated therapeutic efficacy against breast, prostate, and ovarian cancer and other solid tumors. The tumoricidal activity of docetaxel is…”
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Administration of IFN-α enhances the efficacy of a granulocyte macrophage colony stimulating factor-secreting tumor cell vaccine by PRELL, Rodney A, LI, Betty, JIAN MIN LIN, VANROEY, Melinda, JOOSS, Karin

“…IFN-alpha is approved for the treatment of multiple cancers. Its pleiotropic properties include inhibition of proliferation and angiogenesis and induction of…”
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Engagement of OX40 Enhances Antigen-Specific CD4+ T Cell Mobilization/Memory Development and Humoral Immunity: Comparison of αOX-40 with αCTLA-4 by Evans, Dean E., Prell, Rodney A., Thalhofer, Colin J., Hurwitz, Arthur A., Weinberg, Andrew D.

“…Abstract Increasing the long-term survival of memory T cells after immunization is key to a successful vaccine. In the past, the generation of large numbers of…”
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578. Enhancement of GM-CSF Secreting Tumor Cell Vaccines by Docetaxel through Immune-Dependent and Independent Mechanisms by Prell, Rodney A, Sampson, Lisa, Vanroey, Melinda, Jooss, Karin U

“…Vaccination of C57BL/6 mice with irradiated GM-CSF-secreting B16F10 tumor cells stimulates potent, long-lasting and specific anti-tumor immunity that prevents…”
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Involvement of altered B7 expression in dioxin immunotoxicity. B7 transfection restores the CTL but not the alloantibody response to the P815 mastocytoma by Prell, R A, Kerkvliet, NI

“…2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a highly toxic environmental contaminant, suppresses both CTL and cytotoxic alloantibody production in C57BL/6 mice…”
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CTL Hyporesponsiveness Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Role of Cytokines and Apoptosis by Prell, Rodney A., Dearstyne, Erica, Steppan, Linda G., Vella, Anthony T., Kerkvliet, Nancy I.

“…Studies have shown that blocking B7-mediated costimulation induces T cell tolerance via anergy or apoptosis. Provision of exogenous IL-2 can reverse or prevent…”
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Engagement of OX40 Enhances Antigen-Specific CD4+ T Cell Mobilization/Memory Development and Humoral Immunity: Comparison of {alpha}OX-40 with {alpha}CTLA-4 by Evans, Dean E, Prell, Rodney A, Thalhofer, Colin J, Hurwitz, Arthur A, Weinberg, Andrew D

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