Search Results - "Preininger, Anita M."

Conformational Flexibility and Structural Dynamics in GPCR-Mediated G Protein Activation: A Perspective by Preininger, Anita M., Meiler, Jens, Hamm, Heidi E.

“…Structure and dynamics of G proteins and their cognate receptors, both alone and in complex, are becoming increasingly accessible to experimental techniques…”
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Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit by Van Eps, Ned, Preininger, Anita M, Alexander, Nathan, Kaya, Ali I, Meier, Scott, Meiler, Jens, Hamm, Heidi E, Hubbell, Wayne L

“…In G-protein signaling, an activated receptor catalyzes GDP/GTP exchange on the Gα subunit of a heterotrimeric G protein. In an initial step, receptor…”
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Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins by Hubbell, Wayne L, Hamm, Heidi E, Oldham, William M, Van Eps, Ned, Preininger, Anita M

“…Heptahelical receptors activate intracellular signaling pathways by catalyzing GTP for GDP exchange on the heterotrimeric G protein alpha subunit (G alpha)…”
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Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins by Oldham, William M, Van Eps, Ned, Preininger, Anita M, Hubbell, Wayne L, Hamm, Heidi E

“…Heterotrimeric G proteins function as molecular relays that mediate signal transduction from heptahelical receptors in the cell membrane to intracellular…”
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Crystal structures of acetate kinases from the eukaryotic pathogens Entamoeba histolytica and Cryptococcus neoformans by Thaker, Tarjani M., Tanabe, Mikio, Fowler, Matthew L., Preininger, Anita M., Ingram-Smith, Cheryl, Smith, Kerry S., Iverson, T.M.

“…Acetate kinases (ACKs) are members of the acetate and sugar kinase/hsp70/actin (ASKHA) superfamily and catalyze the reversible phosphorylation of acetate, with…”
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Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates by Holinstat, Michael, Preininger, Anita M, Milne, Stephen B, Hudson, W James, Brown, H Alex, Hamm, Heidi E

“…Thrombin induces platelet activation through an early, reversible stage of platelet aggregation, which is followed by a later, irreversible stage of platelet…”
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Health Care Equity in the Use of Advanced Analytics and Artificial Intelligence Technologies in Primary Care by Clark, Cheryl R., Wilkins, Consuelo Hopkins, Rodriguez, Jorge A., Preininger, Anita M., Harris, Joyce, DesAutels, Spencer, Karunakaram, Hema, Rhee, Kyu, Bates, David W., Dankwa-Mullan, Irene

“…The integration of advanced analytics and artificial intelligence (AI) technologies into the practice of medicine holds much promise. Yet, the opportunity to…”
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Embedded Mathematics in Chemistry: A Case Study of Students' Attitudes and Mastery by Preininger, Anita M.

“…There are many factors that shape students' attitudes toward science, technology, engineering and mathematics. This exploratory study of high school students…”
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Energetic analysis of the rhodopsin–G-protein complex links the α5 helix to GDP release by Alexander, Nathan S, Preininger, Anita M, Kaya, Ali I, Stein, Richard A, Hamm, Heidi E, Meiler, Jens

“…Activated G protein–coupled receptors promote GDP release by their cognate G proteins, through an allosteric mechanism that remains to be fully determined. Now…”
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Energetic analysis of the rhodopsin-G-protein complex links the alpha 5 helix to GDP release by Alexander, Nathan S, Preininger, Anita M, Kaya, Ali I, Stein, Richard A, Hamm, Heidi E, Meiler, Jens

“…We present a model of interaction of G sub(i) protein with the activated receptor (R*) rhodopsin, which pinpoints energetic contributions to activation and…”
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Comparison of an oncology clinical decision-support system's recommendations with actual treatment decisions by Suwanvecho, Suthida, Suwanrusme, Harit, Jirakulaporn, Tanawat, Issarachai, Surasit, Taechakraichana, Nimit, Lungchukiet, Palita, Decha, Wimolrat, Boonpakdee, Wisanu, Thanakarn, Nittaya, Wongrattananon, Pattanawadee, Preininger, Anita M, Solomon, Metasebya, Wang, Suwei, Hekmat, Rezzan, Dankwa-Mullan, Irene, Shortliffe, Edward, Patel, Vimla L, Arriaga, Yull, Jackson, Gretchen Purcell, Kiatikajornthada, Narongsak

“…IBM(R) Watson for Oncology (WfO) is a clinical decision-support system (CDSS) that provides evidence-informed therapeutic options to cancer-treating…”
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Differences in information accessed in a pharmacologic knowledge base using a conversational agent vs traditional search methods by Preininger, Anita M., Rosario, Bedda L., Buchold, Adam M., Heiland, Jeff, Kutub, Nawshin, Bohanan, Bryan S., South, Brett, Jackson, Gretchen P.

“…•Addition of a conversational agent to Micromedex allowed searches using natural language.•Information access patterns demonstrate users’ willingness to use a…”
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Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes by Zurawski, Zack, Page, Brian, Chicka, Michael C., Brindley, Rebecca L., Wells, Christopher A., Preininger, Anita M., Hyde, Karren, Gilbert, James A., Cruz-Rodriguez, Osvaldo, Currie, Kevin P.M., Chapman, Edwin R., Alford, Simon, Hamm, Heidi E.

“…Gi/o-coupled G protein-coupled receptors can inhibit neurotransmitter release at synapses via multiple mechanisms. In addition to Gβγ-mediated modulation of…”
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Evaluation of an artificial intelligence clinical trial matching system in Australian lung cancer patients by Alexander, Marliese, Solomon, Benjamin, Ball, David L, Sheerin, Mimi, Dankwa-Mullan, Irene, Preininger, Anita M, Jackson, Gretchen Purcell, Herath, Dishan M

“…The objective of this technical study was to evaluate the performance of an artificial intelligence (AI)-based system for clinical trials matching for a cohort…”
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Accuracy of an Artificial Intelligence System for Cancer Clinical Trial Eligibility Screening: Retrospective Pilot Study by Haddad, Tufia, Helgeson, Jane M, Pomerleau, Katharine E, Preininger, Anita M, Roebuck, M Christopher, Dankwa-Mullan, Irene, Jackson, Gretchen Purcell, Goetz, Matthew P

“…Screening patients for eligibility for clinical trials is labor intensive. It requires abstraction of data elements from multiple components of the…”
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Artificial Intelligence Tool for Optimizing Eligibility Screening for Clinical Trials in a Large Community Cancer Center by Beck, J Thaddeus, Rammage, Melissa, Jackson, Gretchen P, Preininger, Anita M, Dankwa-Mullan, Irene, Roebuck, M Christopher, Torres, Adam, Holtzen, Helen, Coverdill, Sadie E, Williamson, M Paul, Chau, Quincy, Rhee, Kyu, Vinegra, Michael

“…Less than 5% of patients with cancer enroll in clinical trials, and 1 in 5 trials are stopped for poor accrual. We evaluated an automated clinical trial…”
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Artificial Intelligence Clinical Evidence Engine for Automatic Identification, Prioritization, and Extraction of Relevant Clinical Oncology Research by Saiz, Fernando Suarez, Sanders, Corey, Stevens, Rick, Nielsen, Robert, Britt, Michael, Yuravlivker, Leemor, Preininger, Anita M, Jackson, Gretchen P

“…We developed a system to automate analysis of the clinical oncology scientific literature from bibliographic databases and match articles to specific patient…”
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Artificial intelligence-based conversational agent to support medication prescribing by Preininger, Anita M, South, Brett, Heiland, Jeff, Buchold, Adam, Baca, Mya, Wang, Suwei, Nipper, Rex, Kutub, Nawshin, Bohanan, Bryan, Jackson, Gretchen Purcell

“…This article describes the system architecture, training, initial use, and performance of Watson Assistant (WA), an artificial intelligence-based…”
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The Potential and the Imperative: the Gap in AI-Related Clinical Competencies and the Need to Close It by Garvey, Kim V., Craig, Kelly Jean Thomas, Russell, Regina G., Novak, Laurie, Moore, Don, Preininger, Anita M., Jackson, Gretchen P., Miller, Bonnie M.

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Effect of an Artificial Intelligence Clinical Decision Support System on Treatment Decisions for Complex Breast Cancer by Xu, Fengrui, Sepúlveda, Martín-J, Jiang, Zefei, Wang, Haibo, Li, Jianbin, Liu, Zhenzhen, Yin, Yongmei, Roebuck, M Christopher, Shortliffe, Edward H, Yan, Min, Song, Yuhua, Geng, Cuizhi, Tang, Jinhai, Purcell Jackson, Gretchen, Preininger, Anita M, Rhee, Kyu

“…To examine the impact of a clinical decision support system (CDSS) on breast cancer treatment decisions and adherence to National Comprehensive Cancer Center…”
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