Search Results - "Preillon, Julie"

Beyond PD-1: Investigating the Therapeutic Potential of TIGIT Blockade in DLBCL by Sunseri, Nicole, Chen, Xiufen, Wald, Noemie, Preillon, Julie, Smith, Sonali M., Driessens, Gregory, Kline, Justin

“…Background: The PD-1/PD-L1 axis is a dominant cancer immune escape pathway, and PD-1 blockade therapy has greatly benefited patients with select solid tumors…”
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Abstract 3249: a-TIGIT mediates antitumor activity through multiple mechanisms of action involving activation of intratumor effector T cells and depletion of regulatory T cells by Preillon, Julie, Denies, Sofie, Jamart, Diane, Carter, Matthew J., Cragg, Mark S., Driessens, Gregory

“…Abstract T cell Immunoreceptor with Ig and ITIM domains (TIGIT) is a co-inhibitory receptor expressed by lymphocytes, preferentially CD8+ T cells, NK, as well…”
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Restoration of T-cell Effector Function, Depletion of Tregs, and Direct Killing of Tumor Cells: The Multiple Mechanisms of Action of a-TIGIT Antagonist Antibodies by Preillon, Julie, Cuende, Julia, Rabolli, Virginie, Garnero, Lucile, Mercier, Marjorie, Wald, Noémie, Pappalardo, Angela, Denies, Sofie, Jamart, Diane, Michaux, Anne-Catherine, Pirson, Romain, Pitard, Vincent, Bagot, Martine, Prasad, Shruthi, Houthuys, Erica, Brouwer, Margreet, Marillier, Reece, Lambolez, Florence, Marchante, Joäo R, Nyawouame, Florence, Carter, Mathew J, Baron-Bodo, Véronique, Marie-Cardine, Anne, Cragg, Mark, Déchanet-Merville, Julie, Driessens, Gregory, Hoofd, Catherine

“…TIGIT is an immune checkpoint inhibitor expressed by effector CD4 and CD8 T cells, NK cells, and regulatory T cells (Tregs). Inhibition of TIGIT-ligand binding…”
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Abstract 3161: Preparation of aclinical trial with a-TIGIT antagonist antibody EOS884448, which demonstrates potent preclinical activity and safe toxicology profile by Nguyen, Thi Lien-Anh, Cuende, Julia, Preillon, Julie, Garnero, Lucile, Rabolli, Virginie, Wald, Noémie, Hoofd, Catherine, Chevron, Patricia, Mercier, Marjorie, De Henau, Olivier, Bodo, Véronique, Driessens, Gregory

“…Abstract T cell Immunoreceptor with Ig and ITIM domains (TIGIT) is a co-inhibitory receptor expressed by lymphocytes, preferentially CD8+, NK, as well as by…”
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DMRT5 Together with DMRT3 Directly Controls Hippocampus Development and Neocortical Area Map Formation by De Clercq, Sarah, Keruzore, Marc, Desmaris, Elodie, Pollart, Charlotte, Assimacopoulos, Stavroula, Preillon, Julie, Ascenzo, Sabrina, Matson, Clinton K, Lee, Melody, Nan, Xinsheng, Li, Meng, Nakagawa, Yasushi, Hochepied, Tino, Zarkower, David, Grove, Elizabeth A, Bellefroid, Eric J

“…Abstract Mice that are constitutively null for the zinc finger doublesex and mab-3 related (Dmrt) gene, Dmrt5/Dmrta2, show a variety of patterning…”
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Abstract 4147: EOS100850, an A2Areceptor antagonist with prolonged pharmacodynamic activity, mediates the generation ofspecific durable immune responses in a murine breast cancer model by Pirson, Romain, Michaux, Anne-Catherine, Jamart, Diane, Preillon, Julie, Frederix, Kim, Basilico, Paola, Martinoli, Chiara, Leroy, Xavier, Driessens, Gregory, Houthuys, Erica, Chappel, Scott, Crosignani, Stefano, Marillier, Reece

“…Abstract We and others have shown that extracellular adenosine (Ado), acting predominantly through the A2A receptor (A2AR), mediates immunosuppression through…”
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Abstract LB-114: a-TIGIT antagonist antibody EOS884448 shows dual mechanism of action by restoration of T cell effector functions and preferential depletion of Treg by LEROY, XAVIER, Hoofd, Catherine, Cuende, Julia, Denies, Sofie, Rabolli, Virginie, Preillon, Julie, Lambolez, Florence, Prasad, Shruthi, Mercier, Marjorie, Nyawouame, Florence, Bodo, Véronique, Wald, Noémie, Driessens, Grégory, Detheux, Michel

“…Abstract T cell Immunoreceptor with Ig and ITIM domains (TIGIT) is a co-inhibitory receptor expressed by lymphocytes, preferentially CD8+ T cells, NK, as well…”
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Abstract LB-291: EOS100850, an insurmountable and non-brain penetrant A2A receptor antagonist, inhibits adenosine-mediated T cell suppression, demonstrates anti-tumor activity and exhibits best-in class characteristics by Houthuys, Erica, Marillier, Reece, Deregnaucourt, Théo, Brouwer, margreet, Basilico, Paola, Pirson, Romain, Marchante, Joao, Prasad, Shruthi, Hermant, Annelise, Nyawouame, Florence, Preillon, Julie, Frederix, Kim, Michaux, Anne Catherine, Lambolez, Florence, Swiercz, Jakub, Driessens, Gregory, Wald, Noemie, Martinoli, Chiara, Bodo, Veronique, Detheux, Michel, Leroy, Xavier, Crosignani, Stefano

“…Abstract High levels of extracellular adenosine in the tumor microenvironment promote tumor immune evasion. We and others have shown that adenosine,…”
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Abstract LB189: Pharmacodynamic assessment of a-TIGIT mAb EOS-448 highlights multiple FcγR-mediated mode-of-actions in blood and tumor of patients with advanced solid tumors by Cuende, Julia, Preillon, Julie, Wald, Noemie, Mercier, Marjorie, Tieppo, Paola, Welsby, Iain, Bodo, Veronique, McGrath, Yvonne, Van Den Mooter, Tom F., Machiels, Jean-Pascal, Truong, Clarisse, De Henau, Olivier, Driessens, Gregory, Libouban, Marion

“…Abstract T cell immunoglobulin and ITIM domain (TIGIT) is an immune checkpoint inhibitor expressed mainly on NK and T cell populations which has demonstrated…”
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Macrophage migration inhibitory factor in head and neck squamous cell carcinoma: clinical and experimental studies by Kindt, Nadège, Preillon, Julie, Kaltner, Herbert, Gabius, Hans-Joachim, Chevalier, Dominique, Rodriguez, Alexandra, Johnson, Bryon D., Megalizzi, Véronique, Decaestecker, Christine, Laurent, Guy, Saussez, Sven

“…Purpose The present in vivo/in vitro study was undertaken in order to evaluate the importance of macrophage migration inhibitory factor (MIF) in the…”
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Abstract 4863: PF-06840003: a highly selective IDO-1 inhibitor that shows good in vivo efficacy in combination with immune checkpoint inhibitors by Tumang, Joseph, Gomes, Bruno, Wythes, Martin, Crosignani, Stefano, Bingham, Patrick, Bottemanne, Pauline, Cannelle, Hélène, Cauwenberghs, Sandra, Chaplin, Jenny, Dalvie, Deepak, Denies, Sofie, De Maeseneire, Coraline, Folger, Peter, Frederix, Kim, Guo, Jie, Hardwick, James, Hook, Ken, Jessen, Katti, Kindt, Erick, Letellier, Marie-Claire, Liao, Kai-Hsin, Li, Wenlin, Maegley, Karen, Marillier, Reece, Miller, Nichol, Murray, Brion, Pirson, Romain, Preillon, Julie, Rabolli, Virginie, Ray, Chad, Scales, Stephanie, Srirangam, Jay, Solowiej, Jim, Streiner, Nicole, Torti, Vince, Tsaparikos, Konstantinos, Vicini, Paolo, Driessens, Gregory, Kraus, Manfred

“…Abstract Tumors use tryptophan-catabolizing enzymes such as Indoleamine 2,3-dioxygenase-1 (IDO-1) to induce an immunosuppressive microenvironment. IDO-1…”
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The Xenopus doublesex-related gene Dmrt5 is required for olfactory placode neurogenesis by Parlier, Damien, Moers, Virginie, Van Campenhout, Claude, Preillon, Julie, Leclère, Lucas, Saulnier, Amandine, Sirakov, Maria, Busengdal, Henriette, Kricha, Sadia, Marine, Jean-Christophe, Rentzsch, Fabian, Bellefroid, Eric J.

“…The Dmrt (doublesex and mab-3 related transcription factor) genes encode a large family of evolutionarily conserved transcription factors whose function in sex…”
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