Search Results - "Prehn, Jochen H."

MicroRNAs in epilepsy: pathophysiology and clinical utility by Henshall, David C, Prof, Hamer, Hajo M, Prof, Pasterkamp, R Jeroen, Prof, Goldstein, David B, Prof, Kjems, Jørgen, Prof, Prehn, Jochen H M, Prof, Schorge, Stephanie, PhD, Lamottke, Kai, PhD, Rosenow, Felix, MD

“…Summary Background Temporal lobe epilepsy is a common and frequently intractable seizure disorder. Its pathogenesis is thought to involve large-scale…”
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Angiogenin and tRNA fragments in Parkinson’s disease and neurodegeneration by Prehn, Jochen H M, Jirström, Elisabeth

“…In this review, we summarise the evidence for a role of the ribonuclease angiogenin in the pathophysiology of neurodegenerative disorders, with a specific…”
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Advances in immunotherapy for the treatment of glioblastoma by Tivnan, Amanda, Heilinger, Tatjana, Lavelle, Ed C., Prehn, Jochen H. M.

“…Glioblastoma (GBM) is an aggressive brain tumour, associated with extremely poor prognosis and although there have been therapeutic advances, treatment options…”
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BCL(X)L and BCL2 increase the metabolic fitness of breast cancer cells: a single-cell imaging study by Lucantoni, Federico, Salvucci, Manuela, Düssmann, Heiko, Lindner, Andreas U., Lambrechts, Diether, Prehn, Jochen H. M.

“…The BCL2 family of proteins regulate apoptosis by controlling mitochondrial outer membrane permeability. However, the effects on mitochondrial structure and…”
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Identification of unique rectal cancer-specific subtypes by Kisakol, Batuhan, Matveeva, Anna, Salvucci, Manuela, Kel, Alexander, McDonough, Elizabeth, Ginty, Fiona, Longley, Daniel B., Prehn, Jochen H. M.

“…Background Existing colorectal cancer subtyping methods were generated without much consideration of potential differences in expression profiles between colon…”
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Ketone body β-hydroxybutyrate (BHB) preserves mitochondrial bioenergetics by Llorente-Folch, I., Düssmann, H., Watters, O., Connolly, N. M. C., Prehn, Jochen H. M.

“…The ketogenic diet is an emerging therapeutic approach for refractory epilepsy, as well as certain rare and neurodegenerative disorders. The main ketone body,…”
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Mucinous adenocarcinoma is a pharmacogenomically distinct subtype of colorectal cancer by Reynolds, Ian S., O’Connell, Emer, Fichtner, Michael, McNamara, Deborah A., Kay, Elaine W., Prehn, Jochen H. M., Furney, Simon J., Burke, John P.

“…Mucinous colorectal cancer is a unique histological subtype that is known to respond poorly to cytotoxic chemotherapy and radiotherapy. There are a number of…”
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Serine-Arginine Protein Kinase 1 (SRPK1): a systematic review of its multimodal role in oncogenesis by Duggan, William P., O’Connell, Emer, Prehn, Jochen H. M., Burke, John P.

“…Alternative splicing is implicated in each of the hallmarks of cancer, and is mechanised by various splicing factors. Serine-Arginine Protein Kinase 1 (SRPK1)…”
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The apoptosome molecular timer synergises with XIAP to suppress apoptosis execution and contributes to prognosticating survival in colorectal cancer by Fullstone, Gavin, Bauer, Tabea L., Guttà, Cristiano, Salvucci, Manuela, Prehn, Jochen H. M., Rehm, Markus

“…The execution phase of apoptosis is a critical process in programmed cell death in response to a multitude of cellular stresses. A crucial component of this…”
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A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy by Venø, Morten T., Reschke, Cristina R., Morris, Gareth, Connolly, Niamh M. C., Su, Junyi, Yan, Yan, Engel, Tobias, Jimenez-Mateos, Eva M., Harder, Lea M., Pultz, Dennis, Haunsberger, Stefan J., Pal, Ajay, Heller, Janosch P., Campbell, Aoife, Langa, Elena, Brennan, Gary P., Conboy, Karen, Richardson, Amy, Norwood, Braxton A., Costard, Lara S., Neubert, Valentin, Del Gallo, Federico, Salvettik, Beatrice, Vangoor, Vamshidhar R., Sanz-Rodriguez, Amaya, Muilu, Juha, Fabene, Paolo F., Pasterkamp, R. Jeroen, Prehn, Jochen H. M., Schorge, Stephanie, Andersen, Jens S., Rosenow, Felix, Bauer, Sebastian, Kjems, Jørgen, Henshallb, David C.

“…Temporal lobe epilepsy is the most common drug-resistant form of epilepsy in adults. The reorganization of neural networks and the gene expression landscape…”
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Integrative network analysis of miRNA-mRNA expression profiles during epileptogenesis in rats reveals therapeutic targets after emergence of first spontaneous seizure by Khemka, Niraj, Morris, Gareth, Kazemzadeh, Laleh, Costard, Lara S., Neubert, Valentin, Bauer, Sebastian, Rosenow, Felix, Venø, Morten T., Kjems, Jørgen, Henshall, David C., Prehn, Jochen H. M., Connolly, Niamh M. C.

“…Epileptogenesis is the process by which a normal brain becomes hyperexcitable and capable of generating spontaneous recurrent seizures. The extensive…”
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An atlas of inter- and intra-tumor heterogeneity of apoptosis competency in colorectal cancer tissue at single-cell resolution by Lindner, Andreas Ulrich, Salvucci, Manuela, McDonough, Elizabeth, Cho, Sanghee, Stachtea, Xanthi, O’Connell, Emer P., Corwin, Alex D., Santamaria-Pang, Alberto, Carberry, Steven, Fichtner, Michael, Van Schaeybroeck, Sandra, Laurent-Puig, Pierre, Burke, John P., McNamara, Deborah A., Lawler, Mark, Sood, Anup, Graf, John F., Rehm, Markus, Dunne, Philip D., Longley, Daniel B., Ginty, Fiona, Prehn, Jochen H. M.

“…Cancer cells’ ability to inhibit apoptosis is key to malignant transformation and limits response to therapy. Here, we performed multiplexed immunofluorescence…”
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Quantification of tRNA fragments by electrochemical direct detection in small volume biofluid samples by McArdle, Hazel, Hogg, Marion C., Bauer, Sebastian, Rosenow, Felix, Prehn, Jochen H. M., Adamson, Kellie, Henshall, David C., Spain, Elaine

“…Elevated levels of transfer RNA (tRNA) fragments were recently identified in plasma samples from people with epilepsy in advance of a seizure, indicting a…”
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Imaging oxygen in neural cell and tissue models by means of anionic cell-permeable phosphorescent nanoparticles by Dmitriev, Ruslan I, Borisov, Sergey M, Kondrashina, Alina V, Pakan, Janelle M. P, Anilkumar, Ujval, Prehn, Jochen H. M, Zhdanov, Alexander V, McDermott, Kieran W, Klimant, Ingo, Papkovsky, Dmitri B

“…Cell-permeable phosphorescent probes enable the study of cell and tissue oxygenation, bioenergetics, metabolism, and pathological states such as stroke and…”
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Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death by Woodley, Keith, Dillingh, Laura S., Giotopoulos, George, Madrigal, Pedro, Rattigan, Kevin M., Philippe, Céline, Dembitz, Vilma, Magee, Aoife M. S., Asby, Ryan, van de Lagemaat, Louie N., Mapperley, Christopher, James, Sophie C., Prehn, Jochen H. M., Tzelepis, Konstantinos, Rouault-Pierre, Kevin, Vassiliou, George S., Kranc, Kamil R., Helgason, G. Vignir, Huntly, Brian J. P., Gallipoli, Paolo

“…Resistance to standard and novel therapies remains the main obstacle to cure in acute myeloid leukaemia (AML) and is often driven by metabolic adaptations…”
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Regulation of Glucose Transporter 3 Surface Expression by the AMP-Activated Protein Kinase Mediates Tolerance to Glutamate Excitation in Neurons by Weisova, Petronela, Concannon, Caoimhin G, Devocelle, Marc, Prehn, Jochen H. M, Ward, Manus W

“…Ischemic and excitotoxic events within the brain result in rapid and often unfavorable depletions in neuronal energy levels. Here, we investigated the…”
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Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis by Wang, Hongfeng, Wang, Nana, Xu, Delai, Ma, Qilian, Chen, Yang, Xu, Shiqiang, Xia, Qin, Zhang, Yan, Prehn, Jochen H. M., Wang, Guanghui, Ying, Zheng

“…Significant evidences indicate that reactive oxygen species (ROS) can induce macroautophagy/autophagy under both physiological and pathological conditions…”
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CHOP regulates the p53―MDM2 axis and is required for neuronal survival after seizures by ENGEL, Tobias, SANZ-RODGRIGUEZ, Amaya, O'BRIEN, Donncha F, PREHN, Jochen H. M, LUCAS, Jose J, HENSHALL, David C, JIMENEZ-MATEOS, Eva M, CONCANNON, Caoimhin G, JIMENEZ-PACHECO, Alba, MORAN, Catherine, MESURET, Guillaume, PETIT, Emilie, DELANTY, Norman, FARRELL, Michael A

“…Hippocampal sclerosis is a frequent pathological finding in patients with temporal lobe epilepsy and can be caused by prolonged single or repeated brief…”
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Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neurons by Theurey, Pierre, Connolly, Niamh M. C., Fortunati, Ilaria, Basso, Emy, Lauwen, Susette, Ferrante, Camilla, Moreira Pinho, Catarina, Joselin, Alvin, Gioran, Anna, Bano, Daniele, Park, David S., Ankarcrona, Maria, Pizzo, Paola, Prehn, Jochen H. M.

“…Mitochondrial dysfunction is implicated in most neurodegenerative diseases, including Alzheimer's disease (AD). We here combined experimental and computational…”
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Circulating miR-330-3p in Late Pregnancy is Associated with Pregnancy Outcomes Among Lean Women with GDM by Pfeiffer, Shona, Sánchez-Lechuga, Begoña, Donovan, Paul, Halang, Luise, Prehn, Jochen H. M., Campos-Caro, Antonio, Byrne, Maria M., López-Tinoco, Cristina

“…Gestational Diabetes Mellitus (GDM) is characterised by insulin resistance accompanied by reduced beta-cell compensation to increased insulin demand, typically…”
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